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18 publications mentioning hsa-mir-516b-2

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-516b-2. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 56
While NFAT5 mRNA levels were not significantly affected by overexpression of hsa-miR-516b, overexpression of hsa-miR-376c or has-miR-486-5p did result in down-regulation of NFAT5, with has-miR-486-5p having the most significant effect (P = 0.0411). [score:8]
Results from Solexa sequencing suggested that hsa-miR-516b, hsa-miR-196b and hsa-miR-376c are significantly up-regulated in patients with active TB, while hsa-miR-486-5p is significantly down-regulated. [score:7]
from Solexa sequencing suggested that hsa-miR-516b, hsa-miR-196b and hsa-miR-376c are significantly up-regulated in patients with active TB, while hsa-miR-486-5p is significantly down-regulated. [score:7]
In addition, hsa-miR-196b and hsa-miR-376c shared the same eight target mRNAs, while hsa-miR-376c, hsa-miR-516b and hsa-miR-486-5p all targeted NFAT5 whose gene and protein expression are known to be strongly induced by M. tuberculosis [16]. [score:7]
In LTBI individuals hsa-miR-516b was up-regulated, while hsa-miR-376c was down-regulated. [score:7]
We overexpressed three miRNAs predicted to target NFAT5 (hsa-miR-376c, hsa-miR-516b and hsa-miR-486-5p) in HEK293 cells and analysed their transcript levels. [score:5]
For example, both hsa-miR-376c and hsa-miR-516b had 11 targets in common, while hsa-miR-376c and hsa-miR-486-5p had 12 targets in common. [score:5]
Although results for hsa-miR-486-5p and hsa-miR-516b were not consistent with those from RNA-Seq (Figure 4 ), hsa-miR-196b was consistently significantly up-regulated in serum from patients with active TB compared with the other three groups using both techniques, and expression of hsa-miR-376c was significantly higher in serum from TB patients than in serum from individuals with LTBI and un-inoculated healthy individuals, suggesting that these two microRNAs have potential as diagnostic markers. [score:5]
Hsa-miR-516b, hsa-miR-486-5p and hsa-miR-376c all target NFAT5 (nuclear factor of activated T-cells 5) (http://ferrolab. [score:3]
microRNA-gene network for hsa-miR-196b, hsa-miR-516b, hsa-miR-376c and hsa-miR-486-5p. [score:1]
Figure 2 shows the microRNA-Gene-Network for miRNAshsa-miR-516b,hsa-miR-196b, hsa-miR-376c and hsa-miR-486-5p. [score:1]
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2
[+] score: 21
Sixteen of 359 miRNAs detected were differentially expressed between tumor and matched benign tissue (adjusted p < 0.05): 9 were upregulated (hsa-miR-19a; hsa-miR-512-3p; hsa-miR-27b; hsa-miR-20a; hsa-miR-28-3p; hsa-miR-200c; hsa-miR-151-3p; hsa-miR-223; hsa-miR-20b), and 7 downregulated (hsa-miR-22; hsa-miR-516-3p; hsa-miR-370; hsa-miR-139-5p; hsa-let-7e; hsa-miR-145-3p; hsa-miR-30c) in tumor tissue in comparison to matched benign tissue (Table 2). [score:9]
Of the seven tumor-tissue miRNAs downregulated, four (hsa-miR-370; hsa-miR-139-5p; hsa-miR-let-7e; hsa-miR30c) were expressed in both tumor and plasma (both free and within exosomes); hsa-miR-516-3p was present in tumor only, and hsa-miR-22 and hsa-miR-145-3p were present in tumor and exosome only. [score:6]
miRNA Expression Cancer association (Y/N) Upregulated (Y/N) hsa-miR-19a Common YY (10) hsa-miR-512-3p T and E only YN (11) hsa-miR-27b Common YY (12) and N (13) hsa-miR-20a Common YY (14) hsa-miR-28-3p Common YY (15) hsa-miR-200c Common YY (16) and N (17) hsa-miR-151-3p Common YY (18) hsa-miR-223 Common YY (19) and N (15) hsa-miR-20b Common YY (20) hsa-miR-22 T and E only YY (19, 21) and N (22) hsa-miR-516-3p T only N N/A hsa-miR-370 Common YY (23) hsa-miR-139-5p Common YN (24) hsa-let-7e Common YN (25) hsa-miR-145-3p T and E only YN (26) hsa-miR-30c Common YN (27) T, tumor; E, exosome. [score:6]
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3
[+] score: 10
However, we identified 8 miRNAs exclusively expressed in FSHD1 samples (miR-330, miR-331-5p, miR-34a, miR-380-3p, miR-516b, miR-582-5p, miR-517* and miR-625) which could represent new biomarkers for this disease. [score:5]
For example, miR-516b, miR-582–5p and miR-625 target AKAP2, which was identified in skeletal muscle, brain and testis, to be involved in the cAMP signaling pathway [59]. [score:3]
We did not observed any miRNAs only detected in control samples but we identified 8 miRNAs which were only expressed in FSHD samples as compared to age-matched controls: miR-330, miR-331–5p, miR-34a, miR-380–3p, miR-516b, miR-582–5p, miR-517* and miR-625. [score:2]
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4
[+] score: 8
MiR-128a, miR-155, and miR-516-3p are highly expressed in NFPAs, whereas miR-155 and miR-93 are highly expressed in GH adenomas. [score:5]
MiR-128a, miR-155, and miR-516-3p can decrease the expression of wee1 by binding to the 3ʹ UTR [29]. [score:3]
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5
[+] score: 8
Based on a large-scale screen for miRNA expression patterns associated with distant metastasis Foekens et al. [17] were able to show that miR-516-3p belongs to four miRNAs the expression of which is associated with an adverse prognosis in estrogen receptor -positive, lymph node -negative primary breast cancer [18]. [score:5]
Interestingly, the expression of a miRNA of the C19MC cluster i. e. miR-516-3p recently has been linked to higher aggressiveness of breast cancer as well. [score:3]
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6
[+] score: 7
Eight miRNAs (miR-183, miR-193a-5p, miR-222, miR-516b, miR-524-5p, miR-601, and miR-629, 99b) were upregulated and five miRNAs (miR-124, miR-32, miR-574-5p, miR-744, and miR-96) were downregulated. [score:7]
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7
[+] score: 5
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-18a, hsa-mir-22, hsa-mir-29a, hsa-mir-30a, hsa-mir-93, hsa-mir-100, hsa-mir-29b-1, hsa-mir-29b-2, mmu-let-7g, mmu-let-7i, mmu-mir-1a-1, mmu-mir-29b-1, mmu-mir-30a, mmu-mir-30b, mmu-mir-124-3, mmu-mir-126a, mmu-mir-9-2, mmu-mir-133a-1, mmu-mir-146a, mmu-mir-200b, mmu-mir-203, mmu-mir-204, mmu-mir-205, hsa-mir-148a, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-30e, hsa-mir-10a, hsa-mir-34a, hsa-mir-203a, hsa-mir-204, hsa-mir-205, hsa-mir-218-1, hsa-mir-218-2, hsa-mir-221, hsa-mir-222, hsa-mir-200b, mmu-mir-34c, mmu-mir-34b, mmu-let-7d, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-30b, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-126, hsa-mir-146a, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-mir-148a, mmu-mir-200a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-18a, mmu-mir-22, mmu-mir-29a, mmu-mir-29c, mmu-mir-93, mmu-mir-34a, hsa-mir-200c, hsa-mir-1-1, mmu-mir-1a-2, mmu-mir-10a, mmu-mir-100, mmu-mir-200c, mmu-mir-218-1, mmu-mir-218-2, mmu-mir-221, mmu-mir-222, mmu-mir-29b-2, mmu-mir-124-1, mmu-mir-124-2, mmu-mir-9-1, mmu-mir-9-3, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-200a, hsa-mir-34b, hsa-mir-34c, hsa-mir-30e, hsa-mir-375, mmu-mir-375, hsa-mir-335, mmu-mir-335, mmu-mir-133a-2, hsa-mir-424, hsa-mir-193b, hsa-mir-512-1, hsa-mir-512-2, hsa-mir-515-1, hsa-mir-515-2, hsa-mir-518f, hsa-mir-518b, hsa-mir-517a, hsa-mir-519d, hsa-mir-516b-1, hsa-mir-517c, hsa-mir-519a-1, hsa-mir-516a-1, hsa-mir-516a-2, hsa-mir-519a-2, hsa-mir-503, mmu-mir-503, hsa-mir-642a, mmu-mir-190b, mmu-mir-193b, hsa-mir-190b, mmu-mir-1b, hsa-mir-203b, mmu-let-7j, mmu-mir-30f, mmu-let-7k, mmu-mir-126b, mmu-mir-9b-2, mmu-mir-124b, mmu-mir-9b-1, mmu-mir-9b-3
Significant expression of miRNAs within this cluster (miR-512-3p, miR-512-5p, mir-515-5p, miR-516b, miR-517a, miR-517c, miR-518b, miR-518f, miR-519a and miR-519d) was observed in the MaSC/basal population (Fig.   3b), whereas no highly expressed luminal-specific primate miRNAs were identified. [score:5]
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8
[+] score: 4
Interestingly, a recent study demonstrates that expression levels of seven placenta-specific miRNAs (miR-518b, miR-1323, miR-516b, miR-515-5p, miR-520h, miR-519d, and miR-526b) were significantly reduced in placentas from IUGR pregnancies than in placentas from uncomplicated pregnancies [146]. [score:3]
Some placental miRNAs (miR-516-5p, -517*, -518b, -520a*, -520h, -525 and -526a) have been detected in maternal plasma and recognized as pregnancy associated miRNAs [152]. [score:1]
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9
[+] score: 4
Conversely, 15 miRNAs resulted downregulated in activated B cells: mir-483, mir-95, mir-326, mir-135a, mir-184, mir-185, mir-516-3p, mir-30b, mir-203, mir-216, mir-150, mir-182*, mir-141 and mir-211 (Table 3). [score:4]
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10
[+] score: 4
Hromadnikova et al. reported an upregulation of circulating C19MC miRNAs (miR-516-5p, miR-517*, miR-520a*, miR-525, and miR526a) in patients with PE (33). [score:4]
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11
[+] score: 4
In DPSCs transfected with mimic miR-516, no effect on the expression of reporter was observed comparable to the DPSCs transfected with miR-NC (Fig. 6C) impeding the specificity of the binding sequences. [score:3]
The resulting vector wild-type indicated as pSV40-WNT5A-WT or mutant type as pSV40-WNT5A-MT was then transfected by using Lipofectamine 2000 (Invitrogen) into hsa-miR-516a-3p mimics (miR-516) DPSCs (mirVana [®], Life Technologies [™)] or miR -negative control (miR-NC) DPSCs (2 × 10 [4] cells) seeded in a 24-well plates. [score:1]
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12
[+] score: 3
In case of miR-516b-3p no targets could be found in miRWalk, so alternatively miRDB prediction database (version 4.0) was used [23, 103]. [score:3]
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13
[+] score: 2
To validate the differential expression of the selected 20 miRNAs, reverse-transcribed and pre-amplified miRNA fractions from 10 additional BM-infiltrating and 10 primary tumors were amplified in a 96 well plate in triplicate using the specific TaqMan [©] human microRNA assays (hsa-miR-324-3p, catalog #002161; hsa-miR-516-3p, catalog #001149; hsa-miR-628-5p, catalog #002433; hsa-miR-659-3p, catalog #001514; hsa-miR-10b, catalog #002218; hsa-miR-128, catalog #002216; mmu-miR-137, catalog #01129; mmu-miR-140, catalog #001187; hsa-miR-16, catalog #000391, hsa-miR-191, catalog #002299; hsa-miR-301, catalog #000528; hsa-miR-361-3p, catalog #002116; hsa-miR-365, catalog #001020; hsa-miR-548d-3p, catalog #001605; hsa-miR-572, catalog #001614; hsa-miR-576-5p, catalog #002350, hsa-miR-616, catalog #001589; hsa-miR-628-3p, catalog #002434; hsa-miR-873, catalog #002356; hsa-miR-98, catalog #000577; U6 snRNA, catalog #001973, Life Technologies). [score:2]
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14
[+] score: 1
By comparison, miRNA transcripts of the C19MC cluster (miR-512, miR-516b, miR-520, and miR-525) were unchanged (Fig. 5). [score:1]
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15
[+] score: 1
A significant elevation of several extracellular placenta-specific miRNA levels was recently showed (miR-516-5p, miR-517, miR-518b, miR-520a, miR-520h, miR-525, and miR-526a,) during early gestation in 7 pregnancies with later onset of preeclampsia and/or FGR [44]. [score:1]
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16
[+] score: 1
We also noticed that a significant number of miRNAs (such as miR-516-3p, miR-744 and miR-506) that had not been previously annotated in male infertility studies were enriched in these gene sets. [score:1]
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17
[+] score: 1
Intriguingly, one recent report identified that miR-7, miR-128a, miR-210, and miR-516-3p were associated with tumor aggressiveness in ER positive and lymph node negative and miR-210 linked with early relapse in ER positive and lymph node negative breast cancer [13]. [score:1]
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18
[+] score: 1
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-16-1, hsa-mir-20a, hsa-mir-21, hsa-mir-22, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-26a-1, hsa-mir-27a, hsa-mir-31, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-101-1, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-16-2, hsa-mir-192, hsa-mir-199a-1, hsa-mir-30c-2, hsa-mir-199a-2, hsa-mir-223, hsa-let-7g, hsa-let-7i, hsa-mir-23b, hsa-mir-125b-1, hsa-mir-132, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-140, hsa-mir-141, hsa-mir-152, hsa-mir-191, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-149, hsa-mir-150, hsa-mir-320a, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-101-2, hsa-mir-99b, hsa-mir-26a-2, hsa-mir-379, hsa-mir-423, hsa-mir-451a, hsa-mir-486-1, hsa-mir-496, hsa-mir-520a, hsa-mir-525, hsa-mir-518b, hsa-mir-516b-1, hsa-mir-516a-1, hsa-mir-516a-2, hsa-mir-92b, hsa-mir-320b-1, hsa-mir-320c-1, hsa-mir-320b-2, bta-mir-26a-2, bta-let-7f-2, bta-mir-101-2, bta-mir-103-1, bta-mir-16b, bta-mir-20a, bta-mir-21, bta-mir-27a, bta-mir-320a-2, bta-mir-125a, bta-mir-125b-1, bta-mir-199a-1, bta-mir-31, bta-mir-140, bta-mir-92a-2, bta-let-7d, bta-mir-132, bta-mir-191, bta-mir-192, bta-mir-22, bta-mir-23a, bta-mir-29c, bta-mir-423, bta-let-7g, bta-mir-24-2, bta-let-7a-1, bta-mir-150, bta-let-7f-1, bta-mir-30c, bta-let-7i, bta-mir-23b, bta-let-7a-2, bta-let-7a-3, bta-let-7b, bta-let-7c, bta-let-7e, bta-mir-103-2, bta-mir-125b-2, bta-mir-99b, hsa-mir-1249, hsa-mir-103b-1, hsa-mir-103b-2, hsa-mir-320d-1, hsa-mir-320c-2, hsa-mir-320d-2, bta-mir-101-1, bta-mir-133a-2, bta-mir-133a-1, bta-mir-141, bta-mir-152, bta-mir-16a, bta-mir-24-1, bta-mir-199a-2, bta-mir-223, bta-mir-26a-1, bta-mir-379, bta-mir-451, bta-mir-486, bta-mir-496, bta-mir-92a-1, bta-mir-92b, bta-mir-1249, bta-mir-320b, bta-mir-320a-1, hsa-mir-320e, hsa-mir-23c, hsa-mir-451b, bta-mir-149, hsa-mir-486-2
Furthermore, the C19MC cluster miRNAs, miR-516-5p, miR-518b, miR-520a and miR-525, are detectable in the human maternal circulation as early as 12 weeks of gestation [24]. [score:1]
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