sort by

16 publications mentioning rno-mir-383

Open access articles that are associated with the species Rattus norvegicus and mention the gene name mir-383. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 49
Amongst these, miR-383 was differentially expressed in all three rats and up-regulated to the largest degree in rat one, and the ten other miRNAs, let-7d*, miR-181b, miR-187, miR-195, miR-214, miR-382, miR-411, miR-466b, miR-592 and miR-1224 were differentially expressed in at least two rats. [score:8]
Experimentally, Lian et al [52] have reported that the expression of hsa-miR-383 is altered in testicular itssues of human patients, and they consider that a potential target of miR-383 may be GADD45G. [score:5]
Hence, miR-383 was differentially expressed in three rats, and let-7d*, miR-181b, miR-187, miR-195, miR-214, miR-382, miR-411, miR-466b, miR-592, miR-1224 were differentially expressed in two rats at least (Additional file 2: Table S4). [score:5]
In dysregulated miRNAs, let-7d*, miR-181b, miR-187, miR-214, miR-383, miR-466b, miR-592, miR-1224 are significantly overexpressed in MrD compared to hippocampus, and miR-195 is downexpressed. [score:5]
When further examined by, the aberrantly expressed miRNAs, except miR-383 and let-7d*, demonstrated differential expression that significantly correlated with the microarray findings. [score:5]
Although the most upregulated miRNAs in three rats were miR-383, miR-451 and miR-219-5p (with logs [FC]: -2.15, -2.21, -2.60) respectively, we wanted to focus on miRNAs that were altered in different rats simultaneously. [score:4]
Rno-miR-383, the most interesting one of these miRNAs, is significantly up-regulated in Hip in all three rats. [score:4]
Notably, miR-383 was not only most upregulated in rat1, but was also high in rat2 and rat3. [score:4]
Beside rno-miR-383, there are also 10 miRNAs differentially expressed in only two rats in this study. [score:3]
Every miRNA has 3 CT values, the mean CT values were showed in the Table 3. We found that except miR-383 and let-7d*, the other 9 miRNAs were significantly higher expressed in the MrD. [score:3]
However, no evidence demonstrates how rno-miR-383 is involved into complicated regulatory net-works in CNS, especially in MrD. [score:2]
There are 17 members from different species that have been sequenced in the mir-383 family, including: bta, cfa, eca, gga, hsa, mdo, mml, mmu, oan, ppy, ptr, rno, ssc, tgu, xtr, aca, sha (http://www. [score:1]
[1 to 20 of 12 sentences]
2
[+] score: 34
We indeed confirmed the upregulation of miR-124a and miR-383 and the downregulation of miR-181a and miR-130b observed by microarray (Fig.   2a–d). [score:7]
The islets of these animals displayed modifications at the level of several miRNAs, including upregulation of miR-34a, miR-124a and miR-383, and downregulation of miR-130b and miR-181a. [score:7]
In contrast, beta cell proliferation was unaffected by overexpression of miR-383 and miR-124a or downregulation of miR-130b (Fig.   6e–g). [score:6]
Downregulation of miR-130b and overexpression of miR-383 did not affect apoptosis of rat (Fig.   5c, e) or human (Fig.   5d, f) islet cells, whereas they exerted a protective effect when the cells were treated with cytokines. [score:6]
Interestingly, miR-124a plays a role in beta cell development [24] and insulin secretion [25], while miR-383 is differentially expressed in db/db mice and in mice fed a high-fat diet, two mo dels of type 2 diabetes [9]. [score:4]
Indeed, downregulation of miR-130b or induction of miR-383 improved the survival of beta cells under proapoptotic conditions. [score:4]
[1 to 20 of 6 sentences]
3
[+] score: 27
Each scatter spot representing average normalized expression level of miRNA in three repeats of each treatment; (b) 13 miRNAs exhibiting aberrant expression in Jurkat cells cultured with TNF-α (20 ng/mL) for 7 days; (c) decreased expression of miR-139-3p, miR-204, miR-760, miR-524-5p, miR-136, miR-548d-3p, miR-214, miR-383, and miR-887 in RA T cells miRNA, compared with normal T cells. [score:6]
Initially, our studies showed that among the expression of T cell miRNAs affected by TNF-α in Jurkat cells, the expression levels of miR-139-3p, miR-204, miR-760, miR-383, miR-524-5p, miR-136, miR-548d-3p, and miR-214 were significantly decreased in RA T cells. [score:5]
The expression levels of 12 miRNAs, including miR-139-3p, miR-204, miR-760, miR-432, miR-524-5p, miR-136, miR-548d-3p, miR-206, miR-214, miR-383, miR-224, and miR-887 were significantly lower, whereas the expression level of miR-146a was significantly higher, in Jurkat cells after being cultured with TNF-α for 7 days (fold change > 4, p < 0.05, Fig.   1b). [score:5]
Decreased expression of miR-139-3p, miR-204, miR-760, miR-524-5p, miR-136, miR-548d-3p, miR-214, miR-383, and miR-887 were noted in RA T cells. [score:3]
The expression levels of miR-383 showed a significant correlation with the use of sulfalsalazine, methotrexate, and daily steroid dosage. [score:3]
The expression of miR-139-3p, miR-204, miR-760, miR-524-5p, miR-136, miR-548d-3p, miR-214, miR-383, and miR-887 was found to be significantly lower in RA T cells (p < 0.05), compared with controls (Fig.   1c). [score:2]
The fold changes of expression levels for these miRNAs were 0.42-fold for miR-139-3p, 0.43-fold for miR-204, 0.13-fold for miR-760, 0.32-fold for miR-524-5p, 0.45-fold for miR-136, 0.19-fold for miR-548d-3p, 0.37-fold for miR-214;0.36-fold for miR-383, and 0.14-fold for miR-887, compared with controls. [score:2]
80) 0.65 (0.45– 0.94) – – – – – – 2.44 (1.08– 5.48) miR-383 1.08 (0.77–1.52) 0.71 (0.24–2.09) – – – 0.33 (0.08–1.36) 0.93 (0.82–1.05) – 0.81 (0.60–1.10) – miR-548d-3p 0.80 (0.52–1.22) 0.55 (0.14–2.16) – 0.62 (0.13–2.96) – – – – – – miR-760 0.72 (0. 46–1.11) 0.97 (0.25–3.81) – – – – – 2.54 (0.94–6.90) 1.35 (0.95–1.93) 3.66 (1.31– 10.22) Values shown are fold change (95% confidence interval) calculated using multiple linear regression analysis, and those in bold represent p < 0.05 ACPAs anti-citrullinated protein antibodies, CRP C-reactive protein, miRNA microRNAs, MTX methotrexate, RF rheumatoid factor [a]Biologic agent including: tumor necrosis factor antagonists, abatacept, and tocilizumab Fig. 1Altered expression of T cell miRNAs affected by TNF-α in patients with RA and healthy controls. [score:1]
[1 to 20 of 8 sentences]
4
[+] score: 15
We then used a screening system based on the luciferase reporter plasmid carrying the full-length 3′UTR of the FSHb mRNA and found that 18 miRNAs, specifically miR-433-3p, miR-323-3p, miR-328a-3p, miR-3573-3p, miR-204-5p, miR-206-5p, miR-31a-5p, miR-7a-5p, miR-880-3p, miR-186-5p, miR-503-5p, miR-383-5p, miR-324-5p, miR-505-5p, miR-27b-3p, miR-221-5p, miR-320-3p and miR-21-3p, could suppress the expression of the reporter by more than 30% (Figure 1). [score:5]
Interestingly, we identified 12 other miRNAs (miR-323-3p, miR-328a-3p, miR-3573-3p, miR-204-5p, miR-206-5p, miR-31a-5p, miR-7a-5p, miR-880-3p, miR-186-5p, miR-503-5p, miR-383-5p and miR-320-3p) that might also regulate FSHb expression, and then affected FSH secretion, but their specific effects need to be verified through further experiments. [score:4]
35 rno-miR-383-5p 820-826 7mer-1A −0.11 rno-miR-409a-5p 639-645 7mer-1A −0.19 rno-miR-433-3p 1044-1050 7mer-m8 −0.14 rno-miR-449c-3p 674-680 7mer-m8 −0.13 rno-miR-503-5p 763-769 7mer-1A −0.22 rno-miR-505-5p 111-117 7mer-1A −0.14 rno-miR-7a-5p 572-578 7mer-1A −0.01 rno-miR-880-3p 586-592 7mer-1A −0.11 rno-miR-9a-3p 272-278 7mer-1A −0.1 Figure 1Effects of the predicted 45 miRNAs on the reporter gene expression of the pmiR-FSHb-3′UTR-WT vector. [score:3]
35 rno-miR-383-5p 820-826 7mer-1A −0.11 rno-miR-409a-5p 639-645 7mer-1A −0.19 rno-miR-433-3p 1044-1050 7mer-m8 −0.14 rno-miR-449c-3p 674-680 7mer-m8 −0.13 rno-miR-503-5p 763-769 7mer-1A −0.22 rno-miR-505-5p 111-117 7mer-1A −0.14 rno-miR-7a-5p 572-578 7mer-1A −0.01 rno-miR-880-3p 586-592 7mer-1A −0.11 rno-miR-9a-3p 272-278 7mer-1A −0.1 Figure 1Effects of the predicted 45 miRNAs on the reporter gene expression of the pmiR-FSHb-3′UTR-WT vector. [score:3]
[1 to 20 of 4 sentences]
5
[+] score: 15
miR-383 is expressed in germ cells and has been shown to target interferon regulatory-factor 1 (IRF-1), a transcription factor that controls expression of genes related to inflammation and injury [30]. [score:8]
IRF-1 expression is increased in neurons following ischaemic injury [31], [32] and it is plausible that decreased miR-383 in the DRG following axotomy can modulate signalling cascades through IRF-1. miR-138 is interesting as it is highly enriched in the synapse and negatively regulates dendritic spine size by targeting the depalmitoylation enzyme acyl protein thioesterase 1 (APT1) [19]. [score:6]
miR-21, miR-223, miR-455-5p, miR-431 and miR-18 were significantly increased, while miR-138, miR-483 and miR-383 were significantly decreased following nerve transection. [score:1]
[1 to 20 of 3 sentences]
6
[+] score: 7
In addition, 6 miRNA downregulated in our analyses (miR-26a, 29a/b/c, 222, and 383, Additional file 4: Table S1) are predicted to bind 3′UTR of Dnmt3B, with miR-222, miR-383 and miR-29b have demonstrated to directly affect Dnmt3B expression [49, 50]. [score:7]
[1 to 20 of 1 sentences]
7
[+] score: 7
Comparing significantly deregulated miRNAs in the SL- and PH-group, we identified 10 miRNAs (rno-miR-100, rno-miR-105, rno-miR-1224, rno-miR-133a/b, rno-miR-383, rno-miR-466c, rno-miR-483, rno-miR-598-5p, and rno-miR-628) that showed similar expression changes in both groups at the same postoperative time point, while one miRNA (rno-miR-29a) was regulated in the opposite direction at the same time point. [score:6]
Out of the 10 miRNAs found to be affected, we were only able to investigate seven miRNAs since expression levels for rno-miR-383, rno-miR-598-5p, and rno-miR-628 were too low for qRT-PCR (CT cycles > 40) in rat liver tissue. [score:1]
[1 to 20 of 2 sentences]
8
[+] score: 6
Six of them, namely, rno-miR-107-5p, rno-miR-383-5p, rno-miR-24-1-5p, rno-mir-191b, rno-miR-196b-5p, and rno-miR-3552, were upregulated, while only rno-mir-194-1 was downregulated in the MCAO group compared with the sham group. [score:6]
[1 to 20 of 1 sentences]
9
[+] score: 5
Other miRNAs from this paper: mmu-mir-30a, mmu-mir-101a, mmu-mir-125a, mmu-mir-125b-2, mmu-mir-132, mmu-mir-134, mmu-mir-135a-1, mmu-mir-138-2, mmu-mir-142a, mmu-mir-150, mmu-mir-154, mmu-mir-182, mmu-mir-183, mmu-mir-24-1, mmu-mir-194-1, mmu-mir-200b, mmu-mir-122, mmu-mir-296, mmu-mir-21a, mmu-mir-27a, mmu-mir-92a-2, mmu-mir-96, rno-mir-322-1, mmu-mir-322, rno-mir-330, mmu-mir-330, rno-mir-339, mmu-mir-339, rno-mir-342, mmu-mir-342, rno-mir-135b, mmu-mir-135b, mmu-mir-19a, mmu-mir-100, mmu-mir-139, mmu-mir-212, mmu-mir-181a-1, mmu-mir-214, mmu-mir-224, mmu-mir-135a-2, mmu-mir-92a-1, mmu-mir-138-1, mmu-mir-181b-1, mmu-mir-125b-1, mmu-mir-194-2, mmu-mir-377, mmu-mir-383, mmu-mir-181b-2, rno-mir-19a, rno-mir-21, rno-mir-24-1, rno-mir-27a, rno-mir-30a, rno-mir-92a-1, rno-mir-92a-2, rno-mir-96, rno-mir-100, rno-mir-101a, rno-mir-122, rno-mir-125a, rno-mir-125b-1, rno-mir-125b-2, rno-mir-132, rno-mir-134, rno-mir-135a, rno-mir-138-2, rno-mir-138-1, rno-mir-139, rno-mir-142, rno-mir-150, rno-mir-154, rno-mir-181b-1, rno-mir-181b-2, rno-mir-183, rno-mir-194-1, rno-mir-194-2, rno-mir-200b, rno-mir-212, rno-mir-181a-1, rno-mir-214, rno-mir-296, mmu-mir-376b, mmu-mir-370, mmu-mir-433, rno-mir-433, mmu-mir-466a, rno-mir-224, mmu-mir-483, rno-mir-483, rno-mir-370, rno-mir-377, mmu-mir-542, rno-mir-542-1, mmu-mir-494, mmu-mir-20b, mmu-mir-503, rno-mir-494, rno-mir-376b, rno-mir-20b, rno-mir-503-1, mmu-mir-1224, mmu-mir-551b, mmu-mir-672, mmu-mir-455, mmu-mir-490, mmu-mir-466b-1, mmu-mir-466b-2, mmu-mir-466b-3, mmu-mir-466c-1, mmu-mir-466e, mmu-mir-466f-1, mmu-mir-466f-2, mmu-mir-466f-3, mmu-mir-466g, mmu-mir-466h, mmu-mir-504, mmu-mir-466d, mmu-mir-872, mmu-mir-877, rno-mir-466b-1, rno-mir-466b-2, rno-mir-466c, rno-mir-872, rno-mir-877, rno-mir-182, rno-mir-455, rno-mir-672, mmu-mir-466l, mmu-mir-466i, mmu-mir-466f-4, mmu-mir-466k, mmu-mir-466j, rno-mir-551b, rno-mir-490, rno-mir-1224, rno-mir-504, mmu-mir-466m, mmu-mir-466o, mmu-mir-466c-2, mmu-mir-466b-4, mmu-mir-466b-5, mmu-mir-466b-6, mmu-mir-466b-7, mmu-mir-466p, mmu-mir-466n, mmu-mir-466b-8, rno-mir-466d, mmu-mir-466q, mmu-mir-21b, mmu-mir-21c, mmu-mir-142b, mmu-mir-466c-3, rno-mir-322-2, rno-mir-503-2, rno-mir-466b-3, rno-mir-466b-4, rno-mir-542-2, rno-mir-542-3
For example, miRNA-503, miRNA-224 and miRNA-383 are expressed almost exclusively in mouse granulosa cells and oocytes [68], [72], whereas a large number of miRNAs are differentially expressed in bovine ovarian cortex, cumulus cells and corpus luteum [60]. [score:5]
[1 to 20 of 1 sentences]
10
[+] score: 4
In contrast, only one miRNA, miR-383, showed more than 10-fold down-regulation. [score:4]
[1 to 20 of 1 sentences]
11
[+] score: 4
And 17 miRNAs are downregulated as shown in the lower part of this figure, let-7d, miR-665, miR-125b*, let-7b*, miR-124*, miR-770, miR-383, miR-29b-2*, miR-760-3p, miR-324-3p, miR-135b, miR-21, miR-409-5p, let-7f-1*, miR-28, miR-499*,let-7i* (Table 2). [score:4]
[1 to 20 of 1 sentences]
12
[+] score: 3
org) revealed several miRNA that might interact with POMC mRNA untranslated region, including miR-488, miR-485, miR-384-3p, miR-383, miR-377, miR-485-5p and miR-181 (family). [score:3]
[1 to 20 of 1 sentences]
13
[+] score: 2
Mir-383 inhibits proliferation, migration and angiogenesis of glioma-exposed endothelial cells in vitro via vegf -mediated fak and src signaling pathways. [score:2]
[1 to 20 of 1 sentences]
14
[+] score: 2
Moreover, miR-383–5p expression was decreased by the OO diet compared with SO, FO, LO, and PO diets. [score:2]
[1 to 20 of 1 sentences]
15
[+] score: 2
Twelve miRNAs (miR-135a, miR-190, miR-22, miR-347, miR-376*, miR-380*, miR-382, miR-383, miR-702-3p, miR-708, miR-873, and miR-99b*) were regulated only in CCE rats (p < 0.05 vs. [score:2]
[1 to 20 of 1 sentences]
16
[+] score: 1
Seven out of 25 microRNAs (miR-367, miR-216b, miR-383, miR-692, miR-135b, miR-145*, miR-877, miR-434-5p and miR-337-5p), were already modulated after 2 weeks of DOX at 3 mg/kg/week (Table 1). [score:1]
[1 to 20 of 1 sentences]