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17 publications mentioning mmu-mir-487b

Open access articles that are associated with the species Mus musculus and mention the gene name mir-487b. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 111
C2C12-DF cells (C2C12 cells grown in differentiation medium) was compared; 42 miRNAs were up-regulated with miR-206, miR-133b and miR-133a being commonly up-regulated (2.21, 1.68 and 1.63 fold in log2 ratio, respectively), and miR-487b, miR-6412 and miR-3963 were down-regulated (−1.98, −2.99 and −2.13 fold in log 2 ratio, respectively). [score:9]
We identified 161 miRNAs to be up-regulated, including miR-206, miR-133b and miR-133a (by 5.84, 5.46 and 5.37 fold in log2 ratio, respectively), while only miR-487b, miR-6412 and miR-3963 were down-regulated by about −1.00 in log2 ratio (−1.70, −0.96 and −0.93 fold in log2 ratio, respectively). [score:7]
We found that miR-206, miR-133a, miR-133b were up-regulated, and miR-487b, miR-3963, and miR-6412 were down-regulated during myogenic differentiation. [score:7]
We identified miR-206, miR-133a, and miR-133b as up-regulated miRNAs and miR-487b, miR-3963 and miR-6412 as down-regulated miRNAs in differentiating cells. [score:7]
miR-487b is commonly and severely down-regulated in prostate cancer cell lines, suggesting that miR-487b may function as a tumor suppressor that regulates cell proliferation, apoptosis, migration and invasion [37]. [score:7]
miR-487b, miR-3963 and miR-6412 significantly suppress expression of troponin T. miRNA mimic transfection and MyoD and myogenin expression in C2C12 cell. [score:7]
miR-487b is predicted to target insulin receptor-like substrate, down-regulation of which may impair skeletal muscle growth [41, 42]. [score:6]
The suppression of troponin T expression was observed from day 1 for miR-487b and miR-6412, and from day 2 for miR-3963. [score:5]
The candidate target for miR-487b varied greatly depending on the database queried and it was difficult to determine a commonly suggested target. [score:5]
Furthermore, miR-487b expression is significantly associated with disease-free survival of non-MYCN-amplified favorable neuroblastoma [38, 39]. [score:5]
Xi et al reported that miR-487b directly targets Wnt5a [43], which is important in proliferation of satellite cells in adult skeletal muscle. [score:4]
Figure 2 miR-487b and miR-3963 transfection down-regulated fast type MyHC. [score:4]
edu/rna22v1.0/), miR-487b directly targets several molecules that are involved in skeletal muscle differentiation, including Wnt3, Wnt5a, troponin T type 3 (skeletal, fast) (TNNT3), myosin, heavy chain 1, skeletal muscle, adult (MYH1), myosin, heavy chain 2, skeletal muscle, adult (MYH2), myosin, heavy chain 3, skeletal muscle, embryonic (MYH3) and myosin, heavy chain 4, skeletal muscle (MYH4). [score:4]
Figure 3 miR-487b, miR-3963 and miR-6412 transfection down-regulated slow type MyHC. [score:4]
Therefore, we searched for specific miRNAs that are involved in myogenic differentiation, and our miRNA microarray data demonstrated two novel miRNAs, miR-487b, miR-3963 and miR-6412 that are specifically down-regulated in C2C12 cells cultured in differentiation medium. [score:4]
We performed quantitative PCR analysis to assess expression of miR-487b, miR-3963 and miR-6412. [score:3]
Transfection of miR-1 positive control, miR-206 and miR-133a resulted in a significant increase of the troponin T -positive cell ratio, while transfection of miR-487b, miR-3963 and miR-6412 mimics significantly decreased troponin T expression (Figure  1). [score:3]
miR-487b and miR-6412 transfection resulted in significantly lower troponin T expression from day 1. Scale bar 50 μm. [score:3]
RT-qPCR forWe performed quantitative PCR analysis to assess expression of miR-487b, miR-3963 and miR-6412. [score:3]
The expression of miR-487b, miR-3963 and miR-6412 was assessed by RT-qPCR. [score:3]
Our results suggest that miR-487b, miR-3963 and miR-6412 are novel muscle-specific miRNAs that may function as negative regulators of skeletal muscle differentiation. [score:2]
Microrna (miRNA) C2C12 myoblast-derived cell Skeletal muscle Myogenic differentiation miR-487b miR-3963 miR-6412 Skeletal muscle development is complex, involving several signaling pathways. [score:2]
In the present study, we identified miR-487b, miR-3963 and miR-6412 as new skeletal muscle differentiation -associated miRNAs. [score:1]
Next, we focused on miR-487b, miR-3963 and miR-6412 transfection, which resulted in decreased differentiation. [score:1]
Some reports suggested that miR-487b is associated with several kinds of pathological condition. [score:1]
miR-487b also promotes epithelial-mesenchymal transition in lung adenocarcinoma cell [40], while several other reports imply roles of miR-487b in cellular proliferation. [score:1]
miR-487b, miR-3963 and miR-6412 mimics significantly decreased the MyHC (slow) positive cell ratio (Figure  3). [score:1]
Transfection of miR-487b and miR-3963 mimics resulted in a significant decrease in the MyHC (fast) positive ratio (Figure  2), while miR-1 positive control, miR-206, miR-133a, miR-133b and miR-6412 did not affect the MyHC (fast) positive cell ratio. [score:1]
Therefore, we focused on miR-206, miR-133a, miR-133b, miR-487b, miR-6412 and miR-3963 as a potential myogenic differentiation-related miRNAs, and the effect of transfection of these miRNAs on cell differentiation was assessed. [score:1]
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2
[+] score: 31
Among the ten miRNAs validated by qRT-PCR, we found that mmu-miR-487b-5p, mmu-miR-709, mmu-miR-182-5p, mmu-miR-214-3p and mmu-miR-467a-3p were up-regulated in HCC-activated Tregs, mmu-miR-142-5p, mmu-miR-30b-5p, mmu-miR-409-3p and mmu-miR-129-5p were down-regulated (P < 0.01), while miR-344e-5p did not change significantly, as shown in Figure 1C. [score:7]
In control Tregs, mmu-miR-487b-5p, mmu-miR-214-3p, mmu-miR-30b-5p and mmu-miR-129-5p showed significant down-regulation while mmu-miR-409-3p showed significant up-regulation (Figure 2C, left). [score:7]
Compared with control Tregs, although mmu-miR-487b-5p and mmu-miR-129-5p showed similar down-regulation in HCC-activated Tregs, mmu-miR-409-3p was actually significantly down-regulated; mmu-miR-214-3p and mmu-miR-30b-5p did not exhibit significant changes (Figure 2C, right). [score:6]
Because miR-487b-5p, miR-709 and miR-467a-3p did not express in human tissue (miRBase 19), we validated the expression levels of the rest six miRNAs. [score:5]
Because miR-487b-5p, miR-709 and miR-467a-3p did not express in human tissue (miRBase 19), we checked the expression levels of the rest six miRNAs in Tregs from peripheral blood samples. [score:5]
As mmu-miR-155 and mmu-let-7i have been well documented in T cells [19, 24, 25], we observed that mmu-miR-487b-5p and mmu-miR-214-3p were classified into the same group with mmu-miR-155 and mmu-let-7i respectively after hierarchical clustering (data not shown). [score:1]
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3
[+] score: 24
In the present study, we found a higher expression of miR-375 and miR-487b in the HA group, which indicated that high concentration of astaxanthin could suppress tumor growth by inducing overexpression of miR-375. [score:7]
In addition, it might suppress tumor growth through inducing overexpression of miR-375 and miR-487b. [score:5]
On the other hand, miR-487b has an important role as a tumor-suppressive by inhibiting cell proliferation, invasion, and migration, and has been mapped to 14q32.31 in metastatic PCa cells [53]. [score:5]
Two miRNAs showing overexpression with a fold variation higher than 1.5 were picked out, one had a 1.9-fold increase (miR-375) and the other had a 2.1-fold increase (miR-487b). [score:3]
Both miR-375 and miR-487b were significantly overexpressed in the HA group (p < 0.05), confirming the results of the array. [score:3]
Formosa A. Markert E. K. Lena A. M. Italiano D. Finazzi-Agro E. Levine A. J. Bernardini S. Garabadgiu A. V. Melino G. Candi E. MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32. [score:1]
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4
[+] score: 7
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-16-1, hsa-mir-17, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-23a, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-27a, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-100, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-16-2, mmu-mir-23b, mmu-mir-27b, mmu-mir-29b-1, mmu-mir-30a, mmu-mir-30b, mmu-mir-127, mmu-mir-128-1, mmu-mir-132, mmu-mir-133a-1, mmu-mir-188, mmu-mir-194-1, mmu-mir-195a, mmu-mir-199a-1, hsa-mir-199a-1, mmu-mir-200b, mmu-mir-205, mmu-mir-206, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-122, mmu-mir-30e, hsa-mir-199a-2, hsa-mir-199b, hsa-mir-205, hsa-mir-211, hsa-mir-212, hsa-mir-214, hsa-mir-217, hsa-mir-200b, hsa-mir-23b, hsa-mir-27b, hsa-mir-30b, hsa-mir-122, hsa-mir-128-1, hsa-mir-132, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-127, hsa-mir-138-1, hsa-mir-188, hsa-mir-194-1, hsa-mir-195, hsa-mir-206, mmu-mir-19b-2, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-mir-200a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-16-1, mmu-mir-16-2, mmu-mir-23a, mmu-mir-26a-1, mmu-mir-26b, mmu-mir-29a, mmu-mir-29c, mmu-mir-27a, mmu-mir-31, mmu-mir-351, hsa-mir-200c, mmu-mir-17, mmu-mir-19a, mmu-mir-100, mmu-mir-200c, mmu-mir-212, mmu-mir-214, mmu-mir-26a-2, mmu-mir-211, mmu-mir-29b-2, mmu-mir-199a-2, mmu-mir-199b, mmu-mir-19b-1, mmu-mir-138-1, mmu-mir-128-2, hsa-mir-128-2, mmu-mir-217, hsa-mir-194-2, mmu-mir-194-2, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-200a, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-379, mmu-mir-379, mmu-mir-133a-2, mmu-mir-133b, hsa-mir-133b, mmu-mir-412, mmu-mir-431, hsa-mir-431, hsa-mir-451a, mmu-mir-451a, mmu-mir-467a-1, hsa-mir-412, hsa-mir-485, hsa-mir-487a, hsa-mir-491, hsa-mir-503, hsa-mir-504, mmu-mir-485, hsa-mir-487b, mmu-mir-503, hsa-mir-556, hsa-mir-584, mmu-mir-665, mmu-mir-669a-1, mmu-mir-674, mmu-mir-690, mmu-mir-669a-2, mmu-mir-669a-3, mmu-mir-669c, mmu-mir-696, mmu-mir-491, mmu-mir-504, hsa-mir-665, mmu-mir-467e, mmu-mir-669k, mmu-mir-669f, hsa-mir-664a, mmu-mir-1896, mmu-mir-1894, mmu-mir-1943, mmu-mir-1983, mmu-mir-1839, mmu-mir-3064, mmu-mir-3072, mmu-mir-467a-2, mmu-mir-669a-4, mmu-mir-669a-5, mmu-mir-467a-3, mmu-mir-669a-6, mmu-mir-467a-4, mmu-mir-669a-7, mmu-mir-467a-5, mmu-mir-467a-6, mmu-mir-669a-8, mmu-mir-669a-9, mmu-mir-467a-7, mmu-mir-467a-8, mmu-mir-669a-10, mmu-mir-467a-9, mmu-mir-669a-11, mmu-mir-467a-10, mmu-mir-669a-12, mmu-mir-3473a, hsa-mir-23c, hsa-mir-4436a, hsa-mir-4454, mmu-mir-3473b, hsa-mir-4681, hsa-mir-3064, hsa-mir-4436b-1, hsa-mir-4790, hsa-mir-4804, hsa-mir-548ap, mmu-mir-3473c, mmu-mir-5110, mmu-mir-3473d, mmu-mir-5128, hsa-mir-4436b-2, mmu-mir-195b, mmu-mir-133c, mmu-mir-30f, mmu-mir-3473e, hsa-mir-6825, hsa-mir-6888, mmu-mir-6967-1, mmu-mir-3473f, mmu-mir-3473g, mmu-mir-6967-2, mmu-mir-3473h
In the microarray data, 12 miRNAs were consistent in their change either with HHcy or diabetes; of which 4 miRNAs were downregulated in both groups (miR-16, miR-1983, miR-412 and miR-487) and 8 miRNAs (miR-194, miR-188, miR-1896, miR-467e, miR-504, miR-5110, miR-669k and miR-696) were upregulated in both groups. [score:7]
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[+] score: 7
The top 8 downregulated (hsa-miR-200c, hsa-miR-212, hsa-miR-29a, hsa-miR-532, hsa-miR-141, hsa-miR-1, hsa-miR-363, hsa-miR-187) and 8 upregulated (hsa-miR-487, hsa-miR-452, hsa-miR-1233, hsa-miR-92a, hsa-miR-106b, hsa-miR-1290, hsa-miR-320, hsa-miR-26a) miRNAs were presented in Figure 1A. [score:7]
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6
[+] score: 7
Four out of seven miRNAs, miR-135a, miR-135b, miR-467b-5p and miR-487b, were confirmed to be significantly up-regulated in ethanol-exposed mice (Fig.   4c). [score:4]
Analysis of putative target genes for miR-487b did not reveal any candidates that are known to play a role in hippocampal function. [score:3]
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7
[+] score: 6
Importantly, the miRNAs miR-495-3p, miR-654-3p, miR-376a-3p and miR-487b-3p exhibited marked downregulation after 5 weeks in contrast to a slight reduction of expression observed for most miRNA genes from this region. [score:6]
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8
[+] score: 6
miR-181, miR-30b* and miR-874 are additional suggestive eQTL with significant genome-wide (α < 0.1) threshold after permutation Similarly, on chromosome 8 we identified eQTL for three miRNAs (miR-486, miR487b and miR-501) in confidence interval 72–95 Mb. [score:2]
miR-181, miR-30b* and miR-874 are additional suggestive eQTL with significant genome-wide (α < 0.1) threshold after permutationSimilarly, on chromosome 8 we identified eQTL for three miRNAs (miR-486, miR487b and miR-501) in confidence interval 72–95 Mb. [score:2]
Helicases like Ddx39, Ddx49, Cd97 and Upf1 were mapped within the confidence interval of miR-486, miR-487b and miR-501 on chromosome 8. Further, four helicases (Ddx50, Ascc3, Ddx21 and Dna2) were mapped within the confidence interval of the eQTL controlling miR-126. [score:1]
In line with this observation, for the eQTL mapped on chromosome 8, two miRNAs (miR-501-3p and miR-486) were clustered with the ‘brown’ module while miR-487 was assigns to the ‘red’ module but had significant module membership with the brown module as well (P = 0.004). [score:1]
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9
[+] score: 6
In our in vivo study, the expression of miRNAs targeting Ras (let-7f, miR-135b, miR-143, miR-466h, miR-470, and miR-487b) was regulated in the lung of metformin -treated mice, along with another miRNA (miR-376c) playing an antioxidant role. [score:6]
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10
[+] score: 4
As observed in Figure 7, 12 miRNAs were up-regulated by UniPR1331 administration resulting in the reduction of a series of gene products including VEGF-A (miR-329, miR-263 and mir-34b), WNT5A (miR-183, miR-487b), Twist1 (miR-183 and miR-329) and ANGPT4. [score:4]
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11
[+] score: 3
Two miRNAs, mmu-miR-487b and mmu-miR-218-1* were expressed only in the injured animals and not in the sham-injured animals i. e., “calibrator not detected”. [score:3]
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12
[+] score: 3
miR-487b + ND miR-590-3p + + +miR-590-3p and other miRNAs were suggested to mediate control of autoimmune gene expression [61]. [score:3]
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13
[+] score: 3
Inhibition of 14q32 microRNAs miR-329, miR-487b, miR-494 and miR-495 increases neovascularization and blood flow recovery after ischemia. [score:3]
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14
[+] score: 3
Welten S. M. Bastiaansen A. J. de Jong R. C. de Vries M. R. Peters E. A. Boonstra M. C. Sheikh S. P. La Monica N. Kandimalla E. R. Quax P. H. Inhibition of 14q32 microRNAs miR-329, miR-487b, miR-494, and miR-495 increases neovascularization and blood flow recovery after ischemia Circ. [score:3]
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15
[+] score: 3
Welten SM Inhibition of 14q32 MicroRNAs miR-329, miR-487b, miR-494, and miR-495 increases neovascularization and blood flow recovery after ischemiaCirc. [score:3]
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16
[+] score: 1
Of these microRNAs, fifteen constructs, including mmu-miR-487b [11, 12], mmu-miR-467e [13], mmu-miR-466d [14], mmu-miR-449a [15, 17, 18, 32, 33], mmu-miR-148a [20], mmu-miR-133a-1 [21], mmu-miR-1-2-as [22], mmu-miR24-2 [23], mmu-miR-1940, mmu-miR-1935, mmu-miR-1931 [24], mmu-miR-1902, mmu-miR-1895, mmu-miR-1894 [24], and mmu-miR-1193, were examined in this study. [score:1]
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17
[+] score: 1
The bar charts on the right show the read counts of 2 miRNAs (miR-487b and miR-330-5p) as examples. [score:1]
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