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12 publications mentioning hsa-mir-601

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-601. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 61
miR-601 has been shown to be a diagnostic serum biomarker for colorectal cancer [44] and has been found to target and downregulate B7-H3, a immunoregulatory protein associated with poor prognosis and metastasis in several cancers and in breast cancer cell lines [41]. [score:7]
S9 TableTwelve genes with the lowest scores and highest probability of being targeted by miR-601 according to TargetScan and microRNA. [score:5]
S8 TableAll targets of both miR-601 and miR-4516 are listed with scores according to both TargetScan and microRNA. [score:5]
To better understand mechanism(s) by which these miRNAs are acting, mRNA targets of all novel miRNAs, including miR-601 and miR-4516 were identified using TargetScan [79] and microRNA. [score:5]
The two miRNAs that were significant within the predictive mo del were miR-601 and miR-4516; both of which were upregulated in patients who experienced biochemical failure post-salvage RT. [score:4]
Additional putative targets of both miR-601 and miR-4516 are shown in S8– S10 Tables and proteins in multiple pathways including apoptosis and cell cycle regulation were identified. [score:4]
Although miR-601 appears to be a major player in predictive ability of salvage radiation response, miR-4516 and miR-601 together appear to be correlated (Pearson r = 0.56, p-value <0.0001) and target pathways of both STAT3 and NF-kB pathways that are critical regulators of the inflammatory responses in cancer [89]. [score:4]
Importantly, for this study, miR-601 has been shown to be differentially expressed post-radiation in human lymphocytes [40] and has been identified in PC-3 released exosomes in vitro [39]. [score:3]
Top 12 putative gene targets and function for miR-601. [score:3]
As for miR-601, it has been shown to be overexpressed in both gastric [42] and esophageal squamous cell carcinoma tumor tissues [43]. [score:3]
Putative targets of miRNAs, miR-601 and miR-4516, within our predictive mo del of biochemical recurrence post-salvage RT (second biochemical recurrence). [score:3]
A potential mechanism for the role of miR-601 and radiation outcomes maybe the involvement of miR-601 in the regulation of the NF-kB pathway [86], an inflammatory signaling pathway that has been shown by multiple groups to be important for radiation response [87, 88]. [score:2]
Predictive effect of miR-601 + miR-4516 & Development of a miRNA -based Predictive Salvage RT Mo del. [score:2]
Six miRNAs (miR-601, miR-628-3p, miR-320e, miR-508-3p, miR-598, and miR-563) have been previously linked to PCa [36, 39, 46– 48, 62, 75, 85] and of those, only miR-320e has shown functional relevance in in vitro studies [46, 47]. [score:1]
A new predictive mo del for biochemical recurrence after salvage radiation therapy was developed; this mo del consisted of miR-4516 and miR-601 together with, Gleason score, and lymph node status. [score:1]
The two miRNAs, miR-601 and miR-4516 alone and together with Gleason score and lymph node status were selected by the mo del. [score:1]
These future analyses will help elucidate the roles that both miR-4516 and miR-601 have in the clinical response to salvage-RT post-prostatectomy. [score:1]
0118745.g004 Fig 4 A K-M plot was generated using the miR-4516 + miR-601 + Gleason score + lymph node status mo del for biochemical recurrence post salvage radiation therapy. [score:1]
An AUC for lymph node and Gleason score was found to be 0.66, the addition of miR-601 and miR-4516 increased the AUC to 0.83 (Fig. 3). [score:1]
Interestingly, each miRNA alone (miR-601 AUC = 0.77 and miR-4516 AUC = 0.68) or together (miR-601 + miR-4516 AUC = 0.76) (Fig. 3) had a better predictive capability than the combination of positive lymph nodes together with Gleason score (AUC = 0.66) (Fig. 3). [score:1]
We showed that miRNAs alone predicted biochemical recurrence post-salvage RT and adding two miRNAs, miR-601 and miR-4516, to lymph node status and Gleason score, greatly improved the predictive ability of these clinical factors alone. [score:1]
Gleason score, lymph node status, hsa-miR-4516, and hsa-miR-601 (red) performs the best with an AUC of 0.83 followed by a mo del containing hsa-miR-601-alone (green) (AUC = 0.77), hsa-miR-4516-alone (blue) (AUC = 0.68), and lastly, Gleason score and lymph node status (grey) (AUC = 0.66). [score:1]
Using the risk score generated by this mo del (miR-4516, miR-601, Gleason score, and lymph node status), patients were classified as high or low risk groups based on median, the probabilities in recurrence post-salvage RT of the two groups were found to be significantly different (log-rank, p<0.001) as shown in Fig. 4. To ensure that hormonal therapy did not confound the predictive mo del, patients that received hormonal treatment at any point were removed from the mo del and the mo del still retained its specificity and sensitivity with a log-rank p-value of 0.016 and AUC value of 0.83 (S1 Fig. ). [score:1]
A K-M plot was generated using the miR-4516 + miR-601 + Gleason score + lymph node status mo del for biochemical recurrence post salvage radiation therapy. [score:1]
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2
[+] score: 58
The overexpression of miR-601 initially detected as well as the down-regulation of miR-147 initially observed were not validated. [score:6]
Based on our results, we propose that miR-601 plays putative tumor suppressor roles in MBs and its up-regulation is subsequently associated with favorable prognosis. [score:6]
However, once more, the overexpression of miR-601 initially detected was not validated, suggesting tumor suppressor activities. [score:5]
Overall, 18 miRNAs were differentially expressed; 5 miRNAs were found up-regulated in the group of patients that are in complete remission when compared to the relapsed or the control groups; miR-3681 (A), miR-601 (B), miR-642a (C), miR-136 (D) and miR-26b (E). [score:5]
Specifically, 2 miRNAs; miR-720a and miR-891a were down-regulated and 6 miRNAs; miR320e, miR-3681, miR-601, miR-642a, miR-136 and miR-26b were overexpressed in the patient cohort when compared to the control group. [score:5]
On the contrary, miR-601 might serve as a novel biomarker for the clinical diagnosis of colorectal cancer when down-regulated [55, 59]. [score:4]
Based on that, miR-601 could serve as a putative tumor suppressor gene, whilst miR-34a as an oncogene. [score:3]
Previous reports were found describing both oncogenic and tumor suppressor roles for miR-601. [score:3]
Following our initial analysis, overall, 11 differentially expressed miRNAs were identified, including miR-1268, miR-2052, miR-26b, miR-3665, miR-3681, miR-3912, miR-519c-3p, miR-601, miR-608, miR-720 and miR-891a. [score:3]
Quantitative Real-Time Polymerase Chain Reaction was performed to validate the expression profiles of miR-34a and miR-601 in all 32 samples initially screened with miRNA microarrays and in an additional independent cohort of 30 patients (21MBs and 9 AT/RTs). [score:3]
Based on the current findings, 8 miRNAs; miR-3681, miR-601, miR-320e, miR-34a, miR-642a, miR-136, miR-26b and miR-192 were found overexpressed in the patient group. [score:3]
Expression measurements of selected targets (mature miR-34a and miR-601) were studied in all tumor (n = 19) and control samples used in the initial miRNA microarray analysis and in an additional blinded independent set of 30 snap-frozen embryonal tumor samples (n = 21 MBs and n = 9 AT/RTs) using qRT-PCR. [score:3]
For instance, elevated expression levels for miR-601 have been previously reported in pediatric ependymomas versus the control cohort and in pediatric glioblastomas when compared to anaplastic astrocytomas [25, 48]. [score:2]
Among them, 6 miRNAs were overexpressed in Group A as compared to the other groups: miR-1268 (A), miR-3681 (B), miR-3912 (C), miR-601 (D), miR-608 (E) and miR-720 (F). [score:2]
Comparison of Real-Time fold change of embryonal, MB and AT/RT samples by initial analysis, by Ferretti et al. microarray fold change by initial and meta-analyses for miR-34a (A) and miR-601 (B). [score:1]
In total, 8 miRNAs were associated with patients’ clinical outcome; miR-3681, miR-601, miR-320e, miR-642a, miR-720, miR-891a, miR-136 and miR-26. [score:1]
Regarding miR-601 initial analysis and meta-analyses did not coincide as far as AT/RTs were concerned. [score:1]
Following associations with certain patients’ clinical characteristics and cross-validation with meta-analyses, there was good evidence that miR-601 emerged as a putative tumor suppressor gene in MBs, whereas miR-34a manifested potential oncogenic roles. [score:1]
Moreover, from current associations, although initially miR-601 emerged as a putative oncogene, neither meta-analysis nor qRT-PCR confirmed this finding. [score:1]
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3
[+] score: 11
Other miRNAs from this paper: hsa-mir-34a, hsa-mir-34b, hsa-mir-34c
Though not significant, some miRNAs, such as hsa-miR-601 was upregulated in MWCNT exposure (Relative Quantification, RQ = 1306.83) while it was downregulated by SWCNT (RQ = 0.01). [score:7]
Since, it has been reported that hsa-miR-601 can down-regulate Fas -induced apoptosis pathway and repressing nuclear factor-kappaB (NF-κ B) transcription factor in A549 cells [75], it could be of interest. [score:4]
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4
[+] score: 9
Of these, 23 miRNAs were up-regulated, 2 down-regulated and one, miR-601, showed an opposite trend. [score:7]
Twenty of the 26 miRNAs belonged exclusively to the sporadic DT group, 5 miRNAs (miR-409-3p, miR-601, miR-542-5p, miR-487b and miR-4707-5p) were present in both tumor types, while miR-497-5p was detected only in Gardner's syndrome samples (Figure 1A and 1B). [score:1]
Five out the 101 miRNAs (miR-409-3p, miR-487b, miR-601, miR-542-5p and miR-4707-5p) were shared by both tumor types, 3 miRNAs (miR-320e, miR-497-5p and miR-2276) were specific to FAP -associated DTs and 93 were specific for sporadic DTs. [score:1]
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5
[+] score: 7
Eight miRNAs (miR-183, miR-193a-5p, miR-222, miR-516b, miR-524-5p, miR-601, and miR-629, 99b) were upregulated and five miRNAs (miR-124, miR-32, miR-574-5p, miR-744, and miR-96) were downregulated. [score:7]
[1 to 20 of 1 sentences]
6
[+] score: 4
Using, miR-1237, miR-30a, miR-598, miR-601, miR-205*, and miR-328 exhibited enrichment of seed regions in the set of mRNAs up-regulated 20 hours after IR. [score:4]
[1 to 20 of 1 sentences]
7
[+] score: 3
First, we compared the predicted motifs by MDS [2] with the experimental validated ones from the original studies and summarized the results in Fig.   4. Through multiple sequence alignment and motif finding using COSMO [16], Villarroya-Beltri et al. predicted two motifs associated with hnRNPA2B1 loading (Column 2) and successfully validated a 4-mer, GGAG, on regulating the expressions of two test miRNAs (miR-17 and miR-601) in exosomes. [score:3]
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8
[+] score: 3
05±8.4 hsa-miR-601 7.2±2 hsa-miR-17-3p 5.9±0.3Expression of miRNAs in HLSCs and their corresponding MVs was analyzed separately (n = 4). [score:3]
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9
[+] score: 3
A similar observation was made for miR-566 and miR-601 that target the same IRE stem-loop structure located in the UTR of the heavy polypeptide-1 ferritin mRNA (Figure 6 bottom panel). [score:3]
[1 to 20 of 1 sentences]
10
[+] score: 2
06 hsa-miR-595 5.29 hsa-miR-92b −9.97 hsa-miR-601 5.88 hsa-miR-765 4.47 hsa-miR-98 5.05 hsa-miR-99a 6.41 TGF-β -treated hsa-miR-20b −1.29 hsa-let-7a 1.38 hsa-miR-221 −1.25 hsa-let-7d 1.43 hsa-miR-605 −4.64 hsa-let-7e 2 hsa-miR-638 −1.40 hsa-miR-125a-5p 2.87 hsa-miR-663 −2.06 hsa-miR-146a 2.72 hsa-miR-720 −2.40 hsa-miR-21 1.14 hsa-miR-23a 1.20 hsa-miR-23b 1.14 hsa-miR-30c 1.89 hsa-miR-483-5p 1.38 hsa-miR-574-5p 2.23 hsa-miR-99b 1.63 10.1371/journal. [score:1]
06 hsa-miR-595 5.29 hsa-miR-92b −9.97 hsa-miR-601 5.88 hsa-miR-765 4.47 hsa-miR-98 5.05 hsa-miR-99a 6.41 TGF-β -treated hsa-miR-20b −1.29 hsa-let-7a 1.38 hsa-miR-221 −1.25 hsa-let-7d 1.43 hsa-miR-605 −4.64 hsa-let-7e 2 hsa-miR-638 −1.40 hsa-miR-125a-5p 2.87 hsa-miR-663 −2.06 hsa-miR-146a 2.72 hsa-miR-720 −2.40 hsa-miR-21 1.14 hsa-miR-23a 1.20 hsa-miR-23b 1.14 hsa-miR-30c 1.89 hsa-miR-483-5p 1.38 hsa-miR-574-5p 2.23 hsa-miR-99b 1.63 10.1371/journal. [score:1]
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11
[+] score: 2
Out of these miRNAs seven were also defined as candidate reference miRNAs (miR-20b, miR-342-3p, miR-1275, miR-145-3p, miR-151-5P, miR-27b-5p, miR-601). [score:1]
Out of these, miR-20b, miR-342-3p (Pool A) and miR-1275, miR-145-3p, miR-151-5p, miR-27b-5p, miR-601 (Pool B) had a maximum of one off-scale/missing C [q] value (Fig. 1). [score:1]
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12
[+] score: 1
In the example sentence “Plasma miR-601 and miR-760 can potentially serve as promising non-invasive biomarkers for the early detection of colorectal cancer” both miR-601 and miR-760 are in a is_a relation with “non_invasive biomarkers” as indicated by the trigger phrase “serve as”. [score:1]
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