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9 publications mentioning hsa-mir-624

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-624. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 103
Increasing evidence suggests that several miRNAs can reduce tumor progression via direct repression of VEGF-C. miR-27b, miR-101, miR-128 and miR-206 have been shown to inhibit lymphangiogenesis and metastasis in a variety of human cancer cells, via the targeting of VEGF-C. 27, 37, 38 This current study demonstrates that BDNF markedly inhibited the expression of miR-624-3p in human chondrosarcoma cells and specimens. [score:10]
BDNF boosts tumor -associated lymphangiogenesis in vivo and increases VEGF-C expression by downregulating miR-624-3p in specimens of chondrosarcoma patientsNext, we examined whether BDNF knockdown suppresses tumor -associated lymphangiogenesis in vivo. [score:9]
In vitro and in vivo data show in this study that BDNF promotes VEGF-C expression and lymphangiogenesis by downregulating miR-624-3p expression through the MEK/ERK/mTOR signaling pathway. [score:8]
Our data show that BDNF promoted VEGF-C expression and increased lymphangiogenesis by downregulating miR-624-3p through the MEK/ERK/mTOR signaling pathway. [score:6]
This pattern is similar to the clinical expression of higher BDNF and VEGF-C expression versus lower miR-624-3p expression in human chondrosarcoma tissue compared with normal cartilage. [score:6]
BDNF boosts tumor -associated lymphangiogenesis in vivo and increases VEGF-C expression by downregulating miR-624-3p in specimens of chondrosarcoma patients. [score:6]
As shown in Figure 5a, BDNF inhibited miR-624-3p expression in a concentration -dependent manner. [score:5]
27, 28 miRNA target prediction using open-source software (TargetScan, miRDB, miRBase and RNA22) revealed that the 3′-UTR of VEGF-C mRNA harbors potential binding sites for miR-624-3p. [score:5]
We also found that miR-624-3p directly inhibited VEGF-C production through binding to the 3’-UTR of the human VEGF-C gene, and thereby negatively regulating VEGF-C -mediated lymphangiogenesis. [score:5]
Our findings imply that BDNF enhances VEGF-C expression by suppressing miR-624-3p in chondrosarcoma patients. [score:5]
In addition, treatment with MEK, ERK and mTOR inhibitors or siRNA reversed BDNF -mediated miR-624-3p expression and VEGF-C-3′-UTR luciferase activity (Figures 5h and k). [score:5]
Collectively, these data suggest that miR-624-3p directly represses VEGF-C expression via binding to the 3′-UTR region of the human VEGF-C gene through the MEK/ERK/mTOR pathway. [score:4]
[30] We found higher expression of TrkB and lower expression of miR-624-3p in JJ012(S10) cells compared with both JJ012 and SW1353 cells (Supplementary Figure S4). [score:4]
Notably, transfection of miR-624-3p mimic also increased miR-624-3p expression (Supplementary Figure S3). [score:3]
BDNF regulates miR-624-3p directly binding to 3'-UTR of VEGF-C in human chondrosarcoma cells. [score:3]
Conversely, miR-624-3p expression was significantly lower in chondrosarcoma patients. [score:3]
We found that miR-624-3p mimic significantly reduced BDNF -induced VEGF-C expression and secretion (Figures 5b and c). [score:3]
In addition, the miR-624-3p mimic markedly inhibited BDNF -induced LEC migration and tube formation (Figures 5d and e). [score:3]
Furthermore, the data clearly showed low miR-624-3p expression in chondrosarcoma patients (Figure 6h). [score:3]
To learn whether miR-624-3p regulates the 3′-UTR region of VEGF-C, we constructed luciferase reporter vectors harboring the wild-type 3′-UTR region of VEGF-C mRNA (VEGF-C-3′-UTR-wt) and a vector containing mismatches in the predicted miR-624-3p binding site (VEGF-C-3′-UTR-mut) (Figure 5f). [score:2]
We next examined whether miR-624-3p regulated BDNF-enhanced VEGF-C production, by transiently transfecting the miR-624-3p mimic into BDNF -treated chondrosarcoma cells. [score:2]
Transfection with the miR-624-3p mimic significantly reduced BDNF -induced VEGF-C production, and LEC migration as well as tube formation. [score:1]
The miR-624-3p mimic, miRNA control, Lipofectamine 2000, and Trizol were purchased from Life Technologies (Carlsbad, CA, USA). [score:1]
We found that transfection with the miR-624-3p mimic antagonized BDNF increased luciferase activity in the VEGF-C-3′-UTR-wt plasmid (Figure 5g). [score:1]
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[+] score: 30
After all the analysis, six out of 9 miRNAs remained significantly and more than 1.5 fold upregulated (miR340*, miR615-5p, miR545:9.1, miR451, miR454* and miR624*) and 1 out of 5 miRNA remained significantly and more than 1.5 fold downregulated (miR-1280) in both analyses (figure 2). [score:7]
Six platelet microRNAs were significantly upregulated (miR340*, miR451, miR454*, miR545:9.1. miR615-5p and miR624*) and one miRNA (miR1280) was significantly downregulated in patients with CAD as compared to healthy controls. [score:6]
The 7 differentially expressed miRNAs identified by the microarray analysis were first validated, by real-time PCR, in validation cohort I. Of the 7 miRNAs, 2 miRNAs, miR340* and miR624*, were significantly upregulated in patients as compared to controls (figure 2). [score:5]
Of the 7 miRNAs identified in the array analysis, the same 2 miRNAs; miR340* and miR624*, were significantly upregulated in patients as compared to controls (figure 2). [score:3]
To investigate whether medication use might have influenced the miRNA expression levels of our two candidate miRNAs, miR340* and miR624*, we also analysed the expression of these miRNAs. [score:3]
MiR340* and miR624* were confirmed to be upregulated in patients with CAD as compared to healthy controls in both validation cohorts. [score:3]
MiRNA array analysis revealed two platelet-derived miRNAs (miR624* and miR340*) to be significantly upregulated in patients with CAD as compared to healthy controls. [score:3]
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[+] score: 6
Two miRNAs, miR-624 and miR-339, were deregulated in ischemic heart disease and coronary artery disease [53, 54]. [score:6]
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[+] score: 4
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-mir-17, hsa-mir-18a, hsa-mir-19a, hsa-mir-20a, hsa-mir-21, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-93, hsa-mir-101-1, hsa-mir-106a, hsa-mir-107, hsa-mir-192, hsa-mir-34a, hsa-mir-204, hsa-mir-205, hsa-mir-214, hsa-mir-215, hsa-mir-222, hsa-mir-223, hsa-mir-1-2, hsa-mir-15b, hsa-mir-125b-1, hsa-mir-141, hsa-mir-191, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-126, hsa-mir-127, hsa-mir-149, hsa-mir-184, hsa-mir-186, hsa-mir-200c, hsa-mir-1-1, hsa-mir-200a, hsa-mir-101-2, hsa-mir-34b, hsa-mir-34c, hsa-mir-339, hsa-mir-146b, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-650, hsa-mir-651, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-449b, hsa-mir-1185-2, hsa-mir-1283-1, hsa-mir-1185-1, hsa-mir-708, hsa-mir-548e, hsa-mir-548j, hsa-mir-1285-1, hsa-mir-1285-2, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-1283-2, hsa-mir-548q, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-548ay, hsa-mir-548az, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc
Overall, the top five up-regulated miRNAs were miR-624, miR-339-5p, miR-191 and miR-651. [score:4]
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[+] score: 3
In addition, 7 miRNAs were expressed in controls and not in sALS [miR-624 (p < 0.001); miR-520e, miR-524-5p, miR-548a-5p, miR-606, miR-612, miR-647(p < 0.05)] (Table  2). [score:3]
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[+] score: 3
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-17, hsa-mir-18a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-20a, hsa-mir-21, hsa-mir-23a, hsa-mir-25, hsa-mir-26a-1, hsa-mir-27a, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-33a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-93, hsa-mir-96, hsa-mir-99a, hsa-mir-100, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-16-2, hsa-mir-198, hsa-mir-199a-1, hsa-mir-148a, hsa-mir-7-1, hsa-mir-7-2, hsa-mir-7-3, hsa-mir-10a, hsa-mir-10b, hsa-mir-34a, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-182, hsa-mir-199a-2, hsa-mir-199b, hsa-mir-203a, hsa-mir-204, hsa-mir-210, hsa-mir-212, hsa-mir-181a-1, hsa-mir-214, hsa-mir-215, hsa-mir-216a, hsa-mir-217, hsa-mir-218-1, hsa-mir-218-2, hsa-mir-219a-1, hsa-mir-221, hsa-mir-222, hsa-mir-223, hsa-mir-224, hsa-let-7g, hsa-let-7i, hsa-mir-15b, hsa-mir-27b, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-125b-1, hsa-mir-128-1, hsa-mir-130a, hsa-mir-132, hsa-mir-135a-1, hsa-mir-135a-2, hsa-mir-142, hsa-mir-145, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-126, hsa-mir-134, hsa-mir-146a, hsa-mir-150, hsa-mir-186, hsa-mir-188, hsa-mir-193a, hsa-mir-194-1, hsa-mir-320a, hsa-mir-155, hsa-mir-181b-2, hsa-mir-128-2, hsa-mir-194-2, hsa-mir-106b, hsa-mir-29c, hsa-mir-219a-2, hsa-mir-34b, hsa-mir-34c, hsa-mir-99b, hsa-mir-130b, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-362, hsa-mir-369, hsa-mir-375, hsa-mir-378a, hsa-mir-382, hsa-mir-340, hsa-mir-328, hsa-mir-342, hsa-mir-151a, hsa-mir-148b, hsa-mir-331, hsa-mir-339, hsa-mir-335, hsa-mir-345, hsa-mir-196b, hsa-mir-424, hsa-mir-425, hsa-mir-20b, hsa-mir-451a, hsa-mir-409, hsa-mir-484, hsa-mir-486-1, hsa-mir-487a, hsa-mir-511, hsa-mir-146b, hsa-mir-496, hsa-mir-181d, hsa-mir-523, hsa-mir-518d, hsa-mir-499a, hsa-mir-501, hsa-mir-532, hsa-mir-487b, hsa-mir-551a, hsa-mir-92b, hsa-mir-572, hsa-mir-580, hsa-mir-550a-1, hsa-mir-550a-2, hsa-mir-590, hsa-mir-599, hsa-mir-612, hsa-mir-625, hsa-mir-627, hsa-mir-629, hsa-mir-33b, hsa-mir-633, hsa-mir-638, hsa-mir-644a, hsa-mir-650, hsa-mir-548d-1, hsa-mir-449b, hsa-mir-550a-3, hsa-mir-151b, hsa-mir-320b-1, hsa-mir-320c-1, hsa-mir-454, hsa-mir-320b-2, hsa-mir-378d-2, hsa-mir-708, hsa-mir-216b, hsa-mir-1290, hsa-mir-320d-1, hsa-mir-320c-2, hsa-mir-320d-2, hsa-mir-378b, hsa-mir-3151, hsa-mir-320e, hsa-mir-378c, hsa-mir-550b-1, hsa-mir-550b-2, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-219b, hsa-mir-203b, hsa-mir-451b, hsa-mir-499b, hsa-mir-378j, hsa-mir-486-2
microRNA analysis from different studies showed that expression of miR-10a, miR-134, miR-214, miR-221, miR-128b, miR-484, miR-572, miR-580, miR-624 and miR-627 was significantly correlated with a favorable clinical outcome [61, 65, 67]. [score:3]
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[+] score: 1
Lastly, hsa-mir-624 did not appear to be related to choriocarcinoma or any other type of cancer, thus appears to be a false discovery. [score:1]
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[+] score: 1
Even the constructs with a cloned size of 647 bp for miR-1284 or 1011 bp for miR-624-3p could produce miRNA at a reasonable level (Figure 1C and 1E ). [score:1]
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[+] score: 1
However, six miRNAs (miR-17, miR-202, miR-425, miR-493, miR-624 and miR-625) had a higher number of sequencing reads originating from the annotated miRNA* strand than the mature miRNA sequence across majority of the libraries (Additional File 3). [score:1]
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