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23 publications mentioning hsa-mir-766

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-766. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 12
Of the three miRNAs present in less than 25% of high-risk women, miR-766-3p is down-regulated, while miR-4727-3p, and miR-208-5p are highly up-regulated. [score:7]
Two-thirds of these miRNAs, hsa-miR-3124-5p (Figure 4A), hsa-miR-1184 (Figure 4B), hsa-miR-4423-3p (Figure 4C), hsa-miR-4529-3p (Figure 4D), hsa-miR-7855 (Figure 4E), and hsa-miR-766-3p (Figure 4G), tended to have lower expression levels in cases, compared with controls. [score:2]
The mo dels generated the following risk score formulas: Formula 1: AUC-selected miRNA-mo deled risk score Risk score = (-1.062 x hsa-miR-3124-5p) + (-0.32 x hsa-miR-1184) + (-0.33 x hsa-miR-4423-3p) + (0.621 x hsa-miR-4529-3p) + (-0.626 x hsa-miR-7855-5p) + (0.359 x hsa-miR-4446-3p) Formula 2: ANOVA-selected miRNA-mo deled risk score Risk score = (-0.274 x hsa-miR-1184) + (-1.305 x hsa-miR-766-3p) + (-0.393 x hsa-miR-4423-3p) + (0.601 x hsa-miR-4727-3p) + (0.229 x hsa-miR-208a-5p)These formula-generated risk scores were applied to miRNA levels from each case and control for discriminatory power. [score:1]
The mo dels generated the following risk score formulas: Formula 1: AUC-selected miRNA-mo deled risk score Risk score = (-1.062 x hsa-miR-3124-5p) + (-0.32 x hsa-miR-1184) + (-0.33 x hsa-miR-4423-3p) + (0.621 x hsa-miR-4529-3p) + (-0.626 x hsa-miR-7855-5p) + (0.359 x hsa-miR-4446-3p) Formula 2: ANOVA-selected miRNA-mo deled risk score Risk score = (-0.274 x hsa-miR-1184) + (-1.305 x hsa-miR-766-3p) + (-0.393 x hsa-miR-4423-3p) + (0.601 x hsa-miR-4727-3p) + (0.229 x hsa-miR-208a-5p) These formula-generated risk scores were applied to miRNA levels from each case and control for discriminatory power. [score:1]
Of note, the 3 miRNAs unique to the ANOVA set (hsa-miR-766-3p, hsa-miR-4727-3p, and hsa-miR-208a-5p) were detected in less than 25% of patients (Table 2, Figure 4G-4I). [score:1]
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2
[+] score: 10
Out of the eight miRNAs, miR-648 was up-regulated and the seven remaining miRNAs were down regulated (miR-744-5p, miR-193b-3p, miR-212-3p, miR-143-3p, miR-93-5p, miR-423-3p and miR-766-3p). [score:5]
We used miScript Primer Assays for 9 miRNAs (miR-744-5p, miR-648, miR-193b-3p, miR-212-3p, miR-143-3p, miR-93-5p, miR-222-3p, miR-423-3p and miR-766-3p) and QuantiTect Primer assays for 9 target genes (CDKN1A, MYC, PTEN, ESR1, ETS1, SOD2, MGMT, KRAS and HNF4A) (Qiagen, Hilden, Germany) to validate the different expression levels of the miRNA and their target genes, which are determined by miRTargetLink prediction software. [score:5]
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3
[+] score: 9
DOT1L [62], MBD3 [64], RCOR2 [69], Sirt6 and Sirt6 -inhibitor miR766 [65] are involved in chromatin remo delling and have been shown to affect reprogramming efficiency when overexpressed or inhibited. [score:7]
Likewise, RNA interference of Sirt6 -inhibitor miR766 increased reprogramming efficiency (~1.5-fold compared to OSKM alone) [65]. [score:2]
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4
[+] score: 8
YIPF2 19p13.2 G VIP unknown ZNHIT3 17q12 G HHUB unknown C11orf75 11q21 B HHUB unknown miR-23b-3p CEACAM1 19q13.2 B HUB T-cell developmentmiR-30c-5pmiR-30d-5p IFNGR2 21q22.11 B HUB T-cell developmentmiR-30c-5pmiR-30d-5p CD59 11p13 C HUB T-cell development let-7f-1-3p CGN 1q21 C HUB T-cell development miR-125b-5p [b]miR-766-3pmiR-125a-5p HSPA13 21q11 C HHUB T-cell development miR-181a-5p [b]miR-200c-3p miR-205-5p ARHGEF4 2q22 D HHUB T-cell development miR-301a-3p DLG3 Xq13.1 D HHUB T-cell development MORC3 21q22.13 D HHUB Epigenetic controllet-7b-3pmiR-200c-3p APP 21q21.3 E VIP Thymic microenviron. [score:8]
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5
[+] score: 7
For top 10 upregulated microRNAs (hsa-miR-197-3p, hsa-miR-574-3p, hsa-miR-885-5p, hsa-miR-483-3p, hsa-miR-1281, hsa-miR-328, hsa-miR-4254, hsa-miR-4290, hsa-miR-1825, hsa-miR-766-3p), we included those have been shown to be deregulated in cancer, and have either expression data or functional studies in stem cells. [score:7]
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6
[+] score: 7
Disruptor of telomeric silencing 1-like (DOT1L) (Onder et al., 2012), methyl-CpG binding domain protein 3 (MBD3) (Rais et al., 2013), rest corepressor 1 (RCOR2) (Yang et al., 2011), sirtuin 6 (Sirt6), and miR766 (a Sirt6 inhibitor) (Sharma et al., 2013) are all involved in chromatin remo deling, thus affecting the efficiency of reprogramming when inhibited or overexpressed. [score:7]
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7
[+] score: 7
miR-184, miR-524-5p, miR-629, and miR-766 were upregulated, while miR-124, miR-222, miR-32, miR-744, and miR-765 were downregulated [28]. [score:7]
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8
[+] score: 7
Among them, we found that some miRNA*s such as hsa-miR-766* were significantly up-regulated in the patient group, whilst some miRNA*s such as hsa-miR-1307* were significantly down-regulated in the patient group with fold changes >2.0 and a p-value of <0.001, suggesting miRNA*s could be involved in the progression of ALL. [score:7]
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9
[+] score: 5
mRNA targets of these two groups of miRNAs were identified using Tarbase 48, 49. miRPath was then used with the group of mRNAs targeted by miR-181a-5p, miR-150-5p, miR-145-5p, miR-425, miR199b-5p, miR-328-3p, miR-766-3p, and miR-142-3p to identify a list of enriched mRNA -associated pathways, identified at p < 0.0001 of statistical significance. [score:5]
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10
[+] score: 5
Other miRNAs from this paper: hsa-mir-7-1, hsa-mir-7-2, hsa-mir-7-3
2011.06.049 21741761 5. Chen C DNA-methylation -mediated repression of miR-766-3p promotes cell proliferation via targeting SF2 expression in renal cell carcinomaInt. [score:5]
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11
[+] score: 4
Apart from miR-766, all the other miRNA were also down-regulated in ATC (Figure 4). [score:4]
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12
[+] score: 4
Indeed, at least five of the 99 miRNAs upregulated by Nef (miR-557, miR-766, miR-1227, miR-1258, and miR-1301) had putative binding sites in the 3’ UTR of viral lytic reactivation activator, Rta [39]. [score:4]
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13
[+] score: 4
In the main study plasma from the 77 subjects were analysed for expression of 12 miRNAs (let-7a, let-7f, miR-19a, miR-22, miR26a, miR28-5p, miR-99b, miR151-5p, miR-221, miR-532-3p, miR-548-3p, miR-766). [score:3]
05, -4.37)−4.68(−4.84, -4.25)0.06(−0.46, 0.63)−4.66(−5,21, 4.24)−4.63(−5.03, -4.27)0.19(−0.45, 0.42)miR-766−3.53(−3.97, -3.30)−3.59(−4.01, -3.32)−0.11(−0.39, 0.39)−3.68(−4.00, -3.41)−3.72(−4.14, -3.44)−0.10(−0. [score:1]
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14
[+] score: 3
Because an interaction between miR-766 and its predictive target mRNA was not experimentally detected (data not shown), we focused on the characterization of miR-574-3p. [score:1]
Among the four miRNAs, induction of miR-574-3p (1.67-fold, p = 0.0011) and miR-766 (1.54-fold, p = 0.0001) was confirmed by quantitative RT-PCR (qRT-PCR). [score:1]
After a 3-h exposure to 2-Gy X-irradiation, the cells showed induction of miR-181d (2.51-fold, p = 0), miR-574-3p (2.27-fold, p = 2.4 × 10 [−34]), miR-197 (2.12-fold, p = 2.9 × 10 [−26]), and miR-766 (1.64-fold, p = 2.5 × 10 [−7]). [score:1]
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15
[+] score: 2
Moreover, we could also confirm the 9 informative miRNAs (miR-505-5p, miR-4467, miR-766, miR-375, miR-708, miR-3622b-3p, miR-296, miR-219 and miR-103) from set B as significant biomarkers by MANCOVA all reaching Bonferroni corrected significance. [score:1]
The MoR plot illustrates the 9 most informative miRNAs, hsa-miR-505-5p, hsa-miR-4467, hsa-miR-766, hsa-miR-375, hsa-miR-708, hsa-miR-3622b-3p, hsa-miR-296, hsa-miR-219 and hsa-miR-103, each reaching a MoR value ≥ 0.57 (critical MoR value on the information chain). [score:1]
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16
[+] score: 1
As observed from Table S3, the top 10 miRs were the same, except for miR-1200 and miR-766 that replaced miR-197 and miR-1296. [score:1]
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17
[+] score: 1
miR-660 positively correlated with seven different transporters, miR-766 positively correlated with three transporters, and miR-886-3p and let-7g positively correlated with two transporters. [score:1]
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18
[+] score: 1
Surprisingly, out of these, only two miRNAs (miR-23a-5p, miR-137) were more abundant in sEVs at both time points (Fig. 5C), while five miRNAs (miR-17-3p, miR-625-3p, miR-766-3p, miR-199b-5p, miR-381-3p) were less abundant in sEVs of senescent cells (Fig. 5D). [score:1]
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19
[+] score: 1
79 ** hsa-mir-365 7.13 *** 77.53 *** hsa-mir-429 54.63 *** 85.25 *** hsa-mir-454 33.25 *** 87.31 - hsa-mir-455-3p 42.76 *** 96.4 - hsa-mir-484 4.83 *** 78.73 - hsa-mir-485-3p 4.75 *** 71.49 *** hsa-mir-501-3p 69.25 *** 91.25 *** hsa-mir-512-5p 21.37 *** 72.89 *** hsa-mir-532-3p 9.5 *** 85.93 *** hsa-mir-541 69.87 *** 97.77 - hsa-mir-600 35.63 *** 93.48 - hsa-mir-625* 28.5 *** 72.89 *** Hits of functional screen Relative percentage of myotubes 1, % of control p value, Mann Whitney test Relative cell count 2, % of control p value, Mann Whitney test hsa-mir-636 2.37 *** 81.98 *** hsa-mir-663 21.38 *** 84.73 *** hsa-mir-664 7.13 *** 82.85 *** hsa-mir-766 45.13 *** 73. [score:1]
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20
[+] score: 1
The “ECM & focal adhesion” node showed higher activity in ER-true tumors, and includes miR-139-5p, miR-149, miR-766, miR-342, miR-214* and miR-31. [score:1]
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21
[+] score: 1
The following are the 10 miRNA precursors with previously unreported antisense transcripts: hsa-miR-33b, hsa-miR-101, hsa-miR-191, hsa-miR-219-2, hsa-miR-374b, hsa-miR-486, hsa-miR-625, hsa-miR-766, hsa-miR-3135b, and hsa-miR-4433. [score:1]
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22
[+] score: 1
Indeed, some miRNAs became undetectable (miR-1274B, miR-572, and miR-766), while others appeared de novo in cells (miR-140-5p, miR-222*, miR-376c, miR-411, and miR-146a) and their SNs (miR-146a, miR-146b, miR-19a, miR-223*, miR-425, and miR-9*) upon MCM -induced inflammation (Figure  2). [score:1]
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23
[+] score: 1
The limiting of prediction mo dels to 15 and 10 miRNAs expectedly resulted in some loss of performance, but it also revealed several miRNAs (miR-140-5p, miR-199a-3p, miR-93, miR-652, miR-1305, miR-224, miR-96, miR-766) that consistently contributed to all mo dels. [score:1]
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