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13 publications mentioning mmu-mir-712

Open access articles that are associated with the species Mus musculus and mention the gene name mir-712. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 39
Although both mmu-miR-712-5p and mmu-miR-712-3p were up-regulated in the plasma samples of T. gondii-infected mice, mmu-miR-712-3p was more significantly up-regulated. [score:7]
To further determine that the up-regulation of mmu-miR-712-3p, mmu-miR-511-5p and mmu-miR-217-5p was specific response to T. gondii infection, we compared the expression of these three miRNAs in mice infected with T. gondii to mice infected with P. berghei, P. yoelii, P. chabaudi, C. parvum, MHV, or S. aureus. [score:5]
The levels of the three miRNAs, mmu-miR-712-3p, mmu-miR-511-5p and mmu-miR-217-5p miRNAs, were found specifically up-regulated in plasma of mice after T. gondii infection. [score:4]
We report the evidence that three miRNAs, including mmu-miR-712-3p, mmu-miR-511-5p and mmu-miR-217-5p, are significantly up-regulated in the plasma of mice after T. gondii infection, which may lead to the discovery of novel biomarkers for T. gondii infection. [score:4]
The expression of the three miRNAs mmu-miR-712-3p, mmu-miR-511-5p and mmu-miR-217-5p were further assessed in a large number of mice infected with either RH or ME49 strain of T. gondii. [score:3]
Figure 3 ROC curve analysis of the expression of plasma levels of mmu-miR-712-3p, mmu-miR-511-5p and mmu-miR-217-5p. [score:3]
Three of those miRNAs (mmu-miR-712-3p, mmu-miR-511-5p and mmu-miR-217-5p) were prominently expressed in mice infected by both the RH and ME49 strains of T. gondii. [score:3]
The miRNAs mmu-miR-712-5p and mmu-miR-712-3p are the mature forms of mmu-miR-712, but the locations of their coding genes are still uncertain and their function unknown. [score:1]
The elevated expression of miRNAs was specific to T. gondiiinfectionWe further investigated if the three elevated circulating miRNAs in plasma, mmu-miR-712-3p, mmu-miR-511-5p and mmu-miR-217-5p, were host specific responses to T. gondii infection. [score:1]
We focused on the analysis of three miRNAs, mmu-miR-712-3p, mmu-miR-511-5p and mmu-miR-217-5p, which were detected abundantly in mice infected with the RH (Type I) and ME49 (Type II) strains of T. gondii. [score:1]
In previous studies, Son et al. reported that mmu-miR-712 derived from pre-ribosomal RNA induced endothelial inflammation and atherosclerosis [33]. [score:1]
Scatter plots of plasma levels of mmu-miR-712-3p (A), mmu-miR-511-5p (B), and mmu-miR-217-5p (C) in mice infected with RH and ME49 strains of T. gondii (n = 20 each) and in healthy subjects (n = 20). [score:1]
Of these miRNAs, mmu-miR-712-3p, mmu-miR-511-5p and mmu-miR-217-5p were detected with the highest abundance (the average Ct values were 17.43, 27.45 and 26.08, respectively). [score:1]
Figure 2 Validation of mmu-miR-712-3p, mmu-miR-511-5p and mmu-miR-217-5p in plasma samples (n = 60). [score:1]
Quantitative analysis of these miRNAs in a large set of plasma samples from mice showed that mmu-miR-712-3p, mmu-miR-511-5p and mmu-miR-217-5p were potentially useful for early stage diagnosis, with a satisfactory degree of sensitivity and specificity. [score:1]
Mmu-miR-712-3p may be involved in vascular smooth muscle cell calcification by disrupting Ca [2+] efflux proteins, which is not related to T. gondii infection [34]. [score:1]
Thus, the data collectively suggest that the elevated responses of mmu-miR-712-3p, mmu-miR-511-5p and mmu-miR-217-5p in T. gondii infected mice were parasite-specific. [score:1]
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2
[+] score: 21
In addition, previous studies have shown that miR-712 downregulates a tissue inhibitor of metalloproteinase 3 (TIMP3), which in turn activates matrix metalloproteinases 2 and 9 (MMP2, MMP9), as well as a disintegrin and metalloproteases 10 and 17 (ADAM10, ADAM17) [40]. [score:6]
Of these, miR-712-5p was the only miRNA found upregulated in both males (log fold change = 0.658) and females (log fold change = 0.543). [score:4]
Two out of the eight upregulated miRNAs (miR-712-5p and miR-694) were not associated with any known pathways by IPA. [score:4]
Specifically, we found nine differentially expressed miRNAs in females exposed to O [3] in proestrus: miR-694 (log fold change = 1.492), miR-9-5p (log fold change = 0.836), miR-712-5p (log fold change = 0.667), miR-181d-5p (log fold change = 0.597), miR-98-5p (log fold change = 0.558), miR-200c-3p (log fold change = 0.525), miR-221-3p (log fold change = 0.385), miR-126a-5p (log fold change = 0.421), and miR-106a-5p (log fold change = − 0.527) (Fig.   7). [score:3]
Of particular interest is the involvement of miR-712 in the regulation of the immune response and O [3] -induced lung inflammation. [score:2]
However, according to the literature, miR-712 and miR-694 are molecules associated with key players in lung inflammation such as CCL8, IL-1RAP, IL-7, STAT5a, VEGFA, and BCL6 (Table  4). [score:1]
Lung miRNome Estrous cycle Air pollution miR-712-5p miR-106a-5p Ground-level ozone (O [3]) is a reactive oxidant gas that is a major constituent of air pollution [1]. [score:1]
[1 to 20 of 7 sentences]
3
[+] score: 12
For example, miR-877-5p and miR-5114 were up-regulated, whereas miR-3963, miR-378a-3p, miR-193b-3p, miR-125a-5p, miR-378b, miR-365-3p, let-7e-5p, and miR-712-5p were down-regulated in the 0.01 Gy-irradiated mouse spleens compared with the sham spleens. [score:6]
Consistent with the results of the microarray analysis, the expression levels of miR-378a-3p, miR-193b-3p, miR-125a-5p, and miR-712-5p decreased in the 0.01 Gy-irradiated mouse spleens compared with the sham group, whereas the expression of miR-3963 did not change significantly. [score:4]
In our qRT-PCR analysis (Fig. 1A), only 5 miRNAs (miR-378a-3p, miR-193b-3p, miR-125a-5p, miR-712-5p, and miR-3963) generated acceptable Ct values, whereas the other 5 miRNAs (miR-877-5p, miR-5114, miR-378b, miR-365-3p, and let-7e-5p) fell below the minimum threshold because of their lower abundance. [score:1]
The levels of miR-378a-3p, miR-193b-3p, miR-125a-5p, and miR-712-5p decreased in response to LDIR, although the level of miR-3963 did not (Fig. 1B). [score:1]
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4
[+] score: 9
Of these, miR-712 is a mechanosensitive miRNA that is upregulated in endothelial cells by disturbed flow, which regulates endothelial dysfunction and atherosclerosis [39, 40]. [score:5]
Furthermore, in this study, eight miRNAs (mmu-miR-711, mmu-miR-712, mmu-miR-713, mmu-miR-714, mmu-miR-715, mmu-miR-716, mmu-miR-717, and mmu-miR-574) were upregulated in DIO mice. [score:4]
[1 to 20 of 2 sentences]
5
[+] score: 6
Indeed, inhibition of miR-712 (or its human homologue miR-205) prevented endothelial inflammation and atherosclerosis in a carotid ligation mo del [34] and aortic dilatation, elastin fragmentation, and aortic rupture in Apoe [−/−] mice, [62] potentially through post-transcriptional regulation of TIMP-3 and associated heightened MMP activity. [score:4]
Kim CW Kumar S Son DJ Jang IH Griendling KK Jo H Prevention of abdominal aortic aneurysm by anti-microRNA-712 or anti-microRNA-205 in angiotensin II-infused mice. [score:1]
Son DJ Kumar S Takabe W Kim CW Ni CW Alberts-Grill N Jang IH Kim S Kim W Won Kang S Baker AH Woong Seo J Ferrara KW Jo H The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis. [score:1]
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6
[+] score: 6
We tested the expression of well-known shear sensitive genes, such as VCAM1, KLF2, KLF4, and Interleukin-8, as well as a shear-sensitive microRNA, miR-712 in response to either LS or OS for 24 h. We found that the expression of OS -induced VCAM1, Interleukin-8 and miR-712 showed a similar magnitude of fold-change in the early and late passages of iMAECs (Figure  5C-E). [score:5]
However, this did not impact EC permeability, as we recently demonstrated with iMAECs that EC permeability can be increased dramatically in response to either OS or miR-712 [41]. [score:1]
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7
[+] score: 5
6 miRNAs (miR-221-3p, miR-181-5p, miR-181b-5p, miR-712-5p, miR-345-5p, miR-100-5p; Fig. 4a2,b2) showed a lower expression level in KO crypts than KO villi, but showed higher expression level in WT crypts than WT villi (Fig. 4b2: Red spots vs Fig. 4a2: Blue spots). [score:5]
[1 to 20 of 1 sentences]
8
[+] score: 4
In the peripheral CD3 [+] T lymphocytes of DBA-2/J strain, we found 11 miRNAs (miR-302c, miR-691, miR-712, miR-125a-3p, miR-29b*, miR-30b*, miR-10b, miR-149, miR-141, miR-1897-5p and miR-690) that were up-regulated. [score:4]
[1 to 20 of 1 sentences]
9
[+] score: 2
Other miRNAs from this paper: mmu-mir-205, hsa-mir-205
AngII infusion could induce endothelial miR-712/miR-205 in AAA, both in vitro and in vivo, and the silencing of miR-712/miR-205 by antisense oligonucleotides could decrease inflammation and the activity of endothelail MMPs, thus preventing AAA development in AngII-infused ApoE [−/−] mice 52. [score:2]
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10
[+] score: 2
Other miRNAs from this paper: mmu-mir-696, mmu-mir-714
Interestingly, some small RNAs, such as piR-38, piR-171, miR-696, miR-712 and miR-714 observed in the datasets we analyzed, can only be mapped to rDNA but not the reference genome. [score:1]
Moreover, some miRNAs including mouse miR-696, miR-712, miR-714 and miR-715 are also mapped to rDNA, and we found that a total of 10 mouse miRNAs are also srRNAs (Table S14). [score:1]
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11
[+] score: 1
In brain tissues, we detected 58 miRNAs in treated mice but not in controls, whereas we detected only four miRNAs (miR-10a, miR-10b, miR-712*, and miR-715) in control brain tissues but not in treated samples [see Supplemental Material, Table 3 (http://www. [score:1]
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12
[+] score: 1
The sequence is similar to mmu-miR-712-3p, six bases are different. [score:1]
[1 to 20 of 1 sentences]
13
[+] score: 1
A number of nanoparticle formulations have proven to be successful platforms for delivery of miRNA mimetics and antagomirs: silica nanoparticles conjugated to a disialoganglioside GD(2) antibody were used for delivery of the pro-apoptotic microRNA miR-34a to mice bearing neuroblastoma tumours 30 and peptide-decorated lipoparticles containing anti-miR-712 have been used to prevent atheroma formation in a mouse mo del of atherosclerosis 31. [score:1]
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