1 |
[+]
score:
22
Other miRNAs from this paper: hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-20a, hsa-mir-21, hsa-mir-30a, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-148a, hsa-mir-30d, hsa-mir-221, hsa-mir-222, hsa-mir-223, hsa-let-7g, hsa-mir-1-2, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-144, hsa-mir-126, hsa-mir-146a, hsa-mir-150, hsa-mir-206, hsa-mir-320a, hsa-mir-1-1, hsa-mir-155, hsa-mir-361, hsa-mir-148b, hsa-mir-133b, hsa-mir-425, hsa-mir-451a, hsa-mir-486-1, hsa-mir-489, hsa-mir-499a, hsa-mir-1224, bta-mir-103-1, bta-mir-148a, bta-mir-20a, bta-mir-21, bta-mir-221, bta-mir-222, bta-mir-30d, bta-mir-320a-2, bta-mir-499, bta-mir-126, bta-mir-148b, bta-mir-29b-2, bta-mir-425, bta-let-7g, bta-mir-30a, bta-mir-150, bta-mir-103-2, bta-mir-19b, hsa-mir-208b, hsa-mir-1246, hsa-mir-1249, hsa-mir-103b-1, hsa-mir-103b-2, bta-mir-1-2, bta-mir-1-1, bta-mir-133a-2, bta-mir-133a-1, bta-mir-133b, bta-mir-144, bta-mir-146a, bta-mir-155, bta-mir-206, bta-mir-208b, bta-mir-223, bta-mir-451, bta-mir-486, bta-mir-489, bta-mir-1224, bta-mir-29b-1, bta-mir-1249, bta-mir-2305, bta-mir-1584, bta-mir-2413, bta-mir-1777a, bta-mir-1777b, bta-mir-2478, bta-mir-320a-1, bta-mir-2888-1, bta-mir-2888-2, hsa-mir-1260b, hsa-mir-4286, bta-mir-148c, hsa-mir-451b, hsa-mir-499b, bta-mir-1246, bta-mir-1260b, bta-mir-4286-1, bta-mir-4286-2, hsa-mir-486-2, bta-mir-148d
According to the results of TargetScan analysis, totally 2743 bovine genes were predicted as the targets of c-miRNAs significantly down-regulated by grazing (miR-19b, miR-148a, miR-150, miR-221, miR-223 miR-320a, miR-361, and miR-486).
[score:8]
MiR-19b and miR-361 are expressed in bovine adipose tissue.
[score:3]
Expression of miR-361 was shown to be altered by treatment with palmitate and oleate in mouse muscle C2C12 cells [24].
[score:3]
Of these c-miRNAs, circulation levels of miR-19b, miR-148a, miR-150, miR-221, miR-223, miR-320a, miR-361, and miR-486 were significantly down-regulated in the grazing cattle compared to housed cattle, whereas the miR-451 level was higher in the grazing than in the housed cattle.
[score:3]
Therefore, miR-361 might be associated with changes in fatty acid content at the potential miR-361 recipient cells less in grazing cattle than in the housed cattle.
[score:1]
Grazing -induced miRNAs: miR-19b, miR-150, miR-223, miR-320a, miR-361.
[score:1]
At 2 mo, the levels of miR-19b, miR-150, miR-223, miR-320a, and miR-361 in the grazing cattle were lower than in the housed cattle (P = 0.015, 0.020, 0.026, 0.023, and 0.089, respectively).
[score:1]
No exercise -induced changes in circulating miR-19b, miR-150, miR-320a, or miR-361 have ever been reported, which may indicate the specificity of changes in those miRNAs to the grazing movements of cattle.
[score:1]
The results of qRT-PCR normalized with the let-7g level showed that the levels of miR-19b, miR-148a, miR-150, miR-221, and miR-361, and miR-486 in the grazing cattle were lower than those in the housed cattle at 1 mo of grazing (P = 0.013, 0.014, 0.093, 0.011, 0.041, and 0.023, respectively) (Fig 6A).
[score:1]
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7
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-21, hsa-mir-23a, hsa-mir-30a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-196a-1, hsa-mir-148a, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-196a-2, hsa-mir-210, hsa-mir-181a-1, hsa-mir-218-1, hsa-let-7g, hsa-let-7i, hsa-mir-23b, hsa-mir-30b, hsa-mir-128-1, hsa-mir-145, hsa-mir-191, hsa-mir-181b-2, hsa-mir-128-2, hsa-mir-30c-1, hsa-mir-99b, hsa-mir-296, hsa-mir-30e, hsa-mir-361, hsa-mir-337, hsa-mir-148b, hsa-mir-196b, hsa-mir-425, hsa-mir-20b, hsa-mir-486-1, hsa-mir-488, hsa-mir-181d, hsa-mir-498, hsa-mir-519c, hsa-mir-520a, hsa-mir-526b, hsa-mir-520d, hsa-mir-506, hsa-mir-92b, hsa-mir-608, hsa-mir-617, hsa-mir-625, hsa-mir-641, hsa-mir-1264, hsa-mir-1271, bta-let-7f-2, bta-mir-103-1, bta-mir-148a, bta-mir-21, bta-mir-30d, bta-mir-128-1, bta-mir-145, bta-mir-181a-2, bta-mir-30b, bta-mir-181b-2, bta-mir-20b, bta-mir-30e, bta-mir-92a-2, bta-let-7d, bta-mir-148b, bta-mir-181c, bta-mir-191, bta-mir-210, bta-mir-23a, bta-mir-425, bta-let-7g, bta-mir-30a, bta-let-7a-1, bta-let-7f-1, bta-mir-30c, bta-let-7i, bta-mir-23b, bta-let-7a-2, bta-let-7a-3, bta-let-7b, bta-let-7c, bta-let-7e, bta-mir-103-2, bta-mir-99b, hsa-mir-890, hsa-mir-888, hsa-mir-889, hsa-mir-938, hsa-mir-1184-1, hsa-mir-1203, hsa-mir-1204, hsa-mir-1265, hsa-mir-103b-1, hsa-mir-103b-2, bta-mir-128-2, bta-mir-181d, bta-mir-196a-2, bta-mir-196a-1, bta-mir-196b, bta-mir-218-1, bta-mir-296, bta-mir-30f, bta-mir-486, bta-mir-488, bta-mir-92a-1, bta-mir-92b, bta-mir-1271, bta-mir-181a-1, bta-mir-181b-1, bta-mir-148c, hsa-mir-1184-2, hsa-mir-1184-3, hsa-mir-486-2, bta-mir-1264, bta-mir-148d
Moreover, miR-361-5p, miR-1184 and miR-218-1* were the top among the upregulated miRNAs while miR-1265, miR-20b*, miR-520d-5p and miR-506 were the top among the downregulated miRNAs in the SE animals.
[score:7]
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score:
6
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-21, hsa-mir-22, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-26b, hsa-mir-27a, hsa-mir-31, hsa-mir-33a, hsa-mir-99a, hsa-mir-100, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-199a-1, hsa-mir-148a, hsa-mir-147a, hsa-mir-34a, hsa-mir-182, hsa-mir-199a-2, hsa-mir-212, hsa-mir-221, hsa-mir-224, hsa-let-7g, hsa-let-7i, hsa-mir-27b, hsa-mir-30b, hsa-mir-125b-1, hsa-mir-130a, hsa-mir-132, hsa-mir-142, hsa-mir-145, hsa-mir-152, hsa-mir-153-1, hsa-mir-153-2, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-127, hsa-mir-134, hsa-mir-200c, hsa-mir-106b, hsa-mir-361, hsa-mir-148b, hsa-mir-20b, hsa-mir-410, hsa-mir-202, hsa-mir-503, hsa-mir-33b, hsa-mir-643, hsa-mir-659, bta-let-7f-2, bta-mir-103-1, bta-mir-148a, bta-mir-21, bta-mir-221, bta-mir-26b, bta-mir-27a, bta-mir-99a, bta-mir-125a, bta-mir-125b-1, bta-mir-145, bta-mir-199a-1, bta-mir-27b, bta-mir-30b, bta-mir-31, bta-mir-127, bta-mir-142, bta-mir-20b, bta-let-7d, bta-mir-132, bta-mir-148b, bta-mir-200c, bta-mir-22, bta-mir-23a, bta-mir-29b-2, bta-let-7g, bta-mir-24-2, bta-let-7a-1, bta-let-7f-1, bta-let-7i, bta-mir-25, bta-let-7a-2, bta-let-7a-3, bta-let-7b, bta-let-7c, bta-let-7e, bta-mir-103-2, bta-mir-125b-2, bta-mir-34a, hsa-mir-708, hsa-mir-147b, hsa-mir-877, hsa-mir-940, hsa-mir-548j, hsa-mir-302e, hsa-mir-103b-1, hsa-mir-103b-2, bta-mir-100, bta-mir-106b, bta-mir-130a, bta-mir-134, bta-mir-147, bta-mir-152, bta-mir-153-1, bta-mir-153-2, bta-mir-182, bta-mir-24-1, bta-mir-199a-2, bta-mir-202, bta-mir-212, bta-mir-224, bta-mir-33a, bta-mir-33b, bta-mir-410, bta-mir-708, bta-mir-877, bta-mir-940, bta-mir-29b-1, bta-mir-148c, bta-mir-503, bta-mir-148d
Among the down-regulated miRNAs, miR-361-5p [47] and miR-27b (homologous to miR-27a, sharing 20 out of 21 nts) [48] were reported as tumor suppressors.
[score:6]
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score:
5
Other miRNAs from this paper: bta-mir-16b, bta-mir-21, bta-mir-127, bta-mir-92a-2, bta-mir-191, bta-mir-22, bta-mir-29c, bta-mir-93, bta-mir-10b, bta-mir-24-2, bta-mir-122, bta-mir-19a, bta-mir-19b, bta-mir-144, bta-mir-146b, bta-mir-16a, bta-mir-24-1, bta-mir-196a-2, bta-mir-196a-1, bta-mir-196b, bta-mir-296, bta-mir-328, bta-mir-339a, bta-mir-375, bta-mir-451, bta-mir-486, bta-mir-744, bta-mir-92a-1, bta-mir-92b, bta-mir-9-1, bta-mir-9-2, bta-mir-1306, bta-mir-1249, bta-mir-339b
The expression of miR-361, miR-16a, miR-146b and miR-24-3p were higher in sera, while the expression of other eight miRNAs (miR-328, miR-1249, miR-1306, miR-339b, miR-339a, miR-296-5p, miR-21-3p and miR-92b) were higher in exosomes (FDR < 0.05, Table 3).
[score:5]
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5 |
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score:
3
Using the Patrocles database, we found polymorphic miRNA target sites for bta-miR-199b, -miR-199a-5p, and -miR-361 in the IL1B gene and for –miR-126 in the CYP11B1 gene.
[score:3]
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