1 |
[+]
score:
24
Other miRNAs from this paper: hsa-let-7c, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-17, hsa-mir-20a, hsa-mir-23a, hsa-mir-24-1, hsa-mir-98, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-181a-1, hsa-mir-216a, hsa-mir-219a-1, hsa-mir-23b, hsa-mir-145, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-129-2, hsa-mir-186, rno-mir-323, rno-mir-329, rno-mir-345, rno-mir-129-2, rno-mir-20a, rno-mir-151, hsa-mir-181b-2, hsa-mir-219a-2, hsa-mir-361, hsa-mir-380, hsa-mir-323a, hsa-mir-151a, hsa-mir-345, rno-let-7c-1, rno-let-7c-2, rno-let-7f-1, rno-let-7f-2, rno-mir-9a-1, rno-mir-9a-3, rno-mir-9a-2, rno-mir-17-1, rno-mir-23a, rno-mir-23b, rno-mir-24-1, rno-mir-98, rno-mir-103-2, rno-mir-103-1, rno-mir-145, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-186, rno-mir-181a-1, rno-mir-216a, rno-mir-219a-1, rno-mir-219a-2, hsa-mir-425, hsa-mir-329-1, hsa-mir-329-2, hsa-mir-181d, hsa-mir-500a, hsa-mir-505, rno-mir-361, rno-mir-505, hsa-mir-151b, hsa-mir-216b, rno-mir-17-2, rno-mir-380, rno-mir-425, rno-mir-500, hsa-mir-103b-1, hsa-mir-103b-2, rno-mir-667, hsa-mir-323b, rno-mir-9b-3, rno-mir-9b-1, rno-mir-216b, rno-mir-9b-2, rno-mir-219b, hsa-mir-500b, hsa-mir-219b
The miR-181 family is particularly enriched in the brain and is involved in autism spectrum disorders [56], schizophrenia [57], Alzheimer disease [58], where they are mainly found to be upregulated.
[score:6]
Note that prenatal stress downregulated miR-181 and miR-186 expression in the frontal cortex.
[score:6]
Downregulation of miR-181 contributes to accelerated HIV -associated dementia in opiate abusers [59].
[score:4]
Downregulation of miR-181 was shown to have protective effects against apoptosis and mitochondrial dysfunction [60].
[score:4]
At the cellular level, miR-181 regulates apoptosis factors such as bcl-2 in astrocytes.
[score:2]
miR-181 and miR-186 were chosen for verification using qRT-PCR analysis.
[score:1]
Stress also led to critical decreases in let-7c, miR-23b, miR-181, and miR186 amounts.
[score:1]
[1 to 20 of 7 sentences]
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2 |
[+]
score:
20
Other miRNAs from this paper: hsa-mir-17, hsa-mir-18a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-20a, hsa-mir-21, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-27a, hsa-mir-30a, hsa-mir-32, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-93, hsa-mir-107, hsa-mir-129-1, hsa-mir-30c-2, hsa-mir-139, hsa-mir-181c, hsa-mir-204, hsa-mir-212, hsa-mir-181a-1, hsa-mir-222, hsa-mir-15b, hsa-mir-23b, hsa-mir-132, hsa-mir-138-2, hsa-mir-140, hsa-mir-142, hsa-mir-129-2, hsa-mir-138-1, hsa-mir-146a, hsa-mir-154, hsa-mir-186, rno-mir-324, rno-mir-140, rno-mir-129-2, rno-mir-20a, rno-mir-7a-1, rno-mir-101b, hsa-mir-29c, hsa-mir-296, hsa-mir-30e, hsa-mir-374a, hsa-mir-380, hsa-mir-381, hsa-mir-324, rno-mir-9a-1, rno-mir-9a-3, rno-mir-9a-2, rno-mir-15b, rno-mir-17-1, rno-mir-18a, rno-mir-19b-1, rno-mir-19b-2, rno-mir-19a, rno-mir-21, rno-mir-23a, rno-mir-23b, rno-mir-24-1, rno-mir-24-2, rno-mir-27a, rno-mir-29c-1, rno-mir-30e, rno-mir-30a, rno-mir-30c-2, rno-mir-32, rno-mir-92a-1, rno-mir-92a-2, rno-mir-93, rno-mir-107, rno-mir-129-1, rno-mir-132, rno-mir-138-2, rno-mir-138-1, rno-mir-139, rno-mir-142, rno-mir-146a, rno-mir-154, rno-mir-181c, rno-mir-186, rno-mir-204, rno-mir-212, rno-mir-181a-1, rno-mir-222, rno-mir-296, rno-mir-300, hsa-mir-20b, hsa-mir-431, rno-mir-431, hsa-mir-433, rno-mir-433, hsa-mir-410, hsa-mir-494, hsa-mir-181d, hsa-mir-500a, hsa-mir-505, rno-mir-494, rno-mir-381, rno-mir-409a, rno-mir-374, rno-mir-20b, hsa-mir-551b, hsa-mir-598, hsa-mir-652, hsa-mir-655, rno-mir-505, hsa-mir-300, hsa-mir-874, hsa-mir-374b, rno-mir-466b-1, rno-mir-466b-2, rno-mir-466c, rno-mir-874, rno-mir-17-2, rno-mir-380, rno-mir-410, rno-mir-500, rno-mir-598-1, rno-mir-674, rno-mir-652, rno-mir-551b, hsa-mir-3065, rno-mir-344b-2, rno-mir-3564, rno-mir-3065, rno-mir-1188, rno-mir-3584-1, rno-mir-344b-1, hsa-mir-500b, hsa-mir-374c, rno-mir-29c-2, rno-mir-3584-2, rno-mir-598-2, rno-mir-344b-3, rno-mir-466b-3, rno-mir-466b-4
Finally, other subsets of miRNAs were either up-regulated (miR-23a-3p, miR132-3p, miR-146a-5p, miR-154-3p, miR-181d-5p, miR-212-3p, miR-212-5p, miR-344b-5p, miR-380-3p, miR-410-3p, miR-433-3p and miR-3584; Fig. 2, Supplementary Fig. S4), or down-regulated (miR-29c-5p, miR-30a-5p, miR-30c-2-3p, miR-30e-3p, miR-138-5p, miR-140-3p, miR-551b-3p and miR-652-3p; Fig. 2, Supplementary Fig. S5) during all phases of the disease.
[score:9]
Some miRNAs (miR-129-1-3p; miR-129-2-3p, miR-129-5p, miR181c-5p, miR181d-5p, miR-409a-5p, miR-655 and miR-874-3p) were up-regulated (Fig. 2, Supplementary Fig. S3A), whereas others (miR-296-5p, miR-500-3p and miR-652-3p) were down-regulated only in the chronic phase, while not being significantly altered during latency (Fig. 2, Supplementary Fig. S3B).
[score:7]
In fact, the expression patterns of miR-20b-5p, miR-142-3p, miR-181d-5p, miR-212-5p, miR-344b-5p and miR-674-3p were identical to those observed using the microarray, and those of miR-21-5p and miR-146a-5p were very similar, although not identical (Fig. 4).
[score:3]
Cluster 4 included miR-181c-5p and miR-181d-5p.
[score:1]
[1 to 20 of 4 sentences]
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3 |
[+]
score:
18
Other miRNAs from this paper: rno-mir-30a, rno-mir-98, rno-mir-124-3, rno-mir-124-1, rno-mir-124-2, rno-mir-130a, rno-mir-130b, rno-mir-142, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-204, rno-mir-181a-1
In taurocholate -induced rats, the mRNA and proteins of miR-181 and mTOR were significantly decreased (P < 0.05) and Akt, Beclin1 and LC3-II expressions were significantly upregulated compared to the control group (P < 0.05).
[score:5]
After PNS treatment, the expressions of miR-181 and mTOR were markedly enhanced (P < 0.05), whereas Akt, Beclin1, and LC3-II expressions were significantly lower compared to the SAP group (P < 0.05).
[score:4]
MiR-181a and miR-181b of the miR-181 family are tumor suppressors for inducing apoptosis [57].
[score:3]
Moreover, miR-181 significantly enhanced drug -induced apoptosis in cancer cells by targeting multiple anti-apoptosis genes, such as Bcl-2 [57, 58].
[score:3]
MiR-181 induced apoptosis in astrocytes by targeting multiple members of the Bcl-2 family [58].
[score:2]
The miR-181 family of miRNAs is a broadly conserved group of miRNAs and its members affect cell proliferation, differentiation and death [27, 28].
[score:1]
[1 to 20 of 6 sentences]
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4 |
[+]
score:
10
Other miRNAs from this paper: rno-mir-18a, rno-mir-21, rno-mir-26a, rno-mir-26b, rno-mir-29b-2, rno-mir-29a, rno-mir-29b-1, rno-mir-29c-1, rno-mir-31a, rno-mir-126a, rno-mir-133a, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-195, rno-mir-199a, rno-mir-208a, rno-mir-181a-1, rno-mir-214, rno-mir-216a, rno-mir-223, rno-mir-451, rno-mir-1, rno-mir-133b, rno-mir-499, rno-mir-711, rno-mir-31b, rno-mir-126b, rno-mir-208b, rno-mir-216b, rno-mir-133c, rno-mir-29c-2, rno-mir-29b-3
On day 7, miR-31, miR-214, miR-199a-5p, and miR-199a-3p were up-regulated, whereas miR-181c, miR-29b, miR-26b, miR-181d, mir-126, mir-499-5p, and miR-1 were down-regulated.
[score:7]
Some of the deregulated miRNAs (miR-181, miR-26, miR-1, mir-29, miR-214, miR-126, and miR-499) are reported to be related to hypoxia, cell development, and cell growth [1, 5, 7, 25].
[score:3]
[1 to 20 of 2 sentences]
|
5 |
[+]
score:
9
Other miRNAs from this paper: rno-let-7d, rno-mir-20a, rno-mir-7a-1, rno-mir-352, rno-mir-7a-2, rno-mir-17-1, rno-mir-24-1, rno-mir-24-2, rno-mir-25, rno-mir-26b, rno-mir-30d, rno-mir-34a, rno-mir-93, rno-mir-98, rno-mir-103-2, rno-mir-103-1, rno-mir-106b, rno-mir-107, rno-mir-122, rno-mir-125b-1, rno-mir-125b-2, rno-mir-126a, rno-mir-133a, rno-mir-143, rno-mir-206, rno-mir-1, rno-mir-133b, rno-mir-374, rno-mir-17-2, rno-mir-126b, rno-mir-133c
The top 10 miRNAs upregulated and downregulated upon treatment with Tg and Tm, respectively are shown in Figure 2B-C. The expression of miR-98, let-7d*, miR-374, miR-181d, miR-352, miR-7a and miR-26b were increased both by Tg and Tm in H9c2 cells.
[score:9]
[1 to 20 of 1 sentences]
|
6 |
[+]
score:
7
Other miRNAs from this paper: rno-mir-323, rno-mir-301a, rno-mir-20a, rno-mir-29b-2, rno-mir-29a, rno-mir-29b-1, rno-mir-29c-1, rno-mir-34b, rno-mir-34c, rno-mir-34a, rno-mir-130b, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-183, rno-mir-199a, rno-mir-200c, rno-mir-200a, rno-mir-200b, rno-mir-181a-1, rno-mir-296, rno-mir-301b, rno-mir-29c-2, rno-mir-29b-3
miRNAs that had approximately 2-fold upregulation included members of miR-29 family and miR-34 family and that were downregulated by about 2-fold were members of the miR-181 family and miR-183 family.
[score:7]
[1 to 20 of 1 sentences]
|
7 |
[+]
score:
7
Other miRNAs from this paper: rno-mir-324, rno-mir-352, rno-mir-19b-1, rno-mir-19b-2, rno-mir-19a, rno-mir-30c-1, rno-mir-30e, rno-mir-30b, rno-mir-30d, rno-mir-30a, rno-mir-30c-2, rno-mir-34a, rno-mir-133a, rno-mir-199a, rno-mir-208a, rno-mir-210, rno-mir-1, rno-mir-133b, rno-mir-378a, rno-mir-133c, rno-mir-378b
We suppose that SFI attenuates myocardial hypertrophy by upregulating the levels of particular miRNAs, including miR-19a-3p, miR-181d-5p, miR-210-3p, miR-352 and miR-324-3p, and downregulating miR-199a-5p.
[score:7]
[1 to 20 of 1 sentences]
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8 |
[+]
score:
6
Other miRNAs from this paper: rno-let-7d, rno-mir-140, rno-mir-342, rno-mir-135b, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c-1, rno-let-7c-2, rno-let-7e, rno-let-7f-1, rno-let-7f-2, rno-let-7i, rno-mir-15b, rno-mir-23b, rno-mir-25, rno-mir-27b, rno-mir-28, rno-mir-29a, rno-mir-30c-1, rno-mir-30e, rno-mir-30b, rno-mir-30d, rno-mir-30a, rno-mir-30c-2, rno-mir-93, rno-mir-98, rno-mir-125a, rno-mir-135a, rno-mir-143, rno-mir-150, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-181a-1, rno-mir-218a-2, rno-mir-218a-1, rno-mir-221, rno-mir-320, rno-mir-503-1, rno-mir-378a, rno-mir-497, rno-mir-425, rno-mir-218b, rno-mir-378b, rno-let-7g, rno-mir-503-2
Among the important genes were Lifr, Acvr1c, and Pparγ which were found to be targeted by microRNAs in our dataset like miR-143, miR-30, miR-140, miR-27b, miR-125a, miR-128ab, miR-342, miR-26ab, miR-181, miR-150, miR-23ab and miR-425.
[score:3]
It was found to be a putative target for let-7 family members, miR-26ab, miR-181 family, miR-150, miR-27b, miR-23ab, miR-425, miR-125a-5p, and miR-128ab.
[score:3]
[1 to 20 of 2 sentences]
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9 |
[+]
score:
6
Other miRNAs from this paper: mmu-mir-1a-1, mmu-mir-127, mmu-mir-134, mmu-mir-136, mmu-mir-154, mmu-mir-181a-2, mmu-mir-143, mmu-mir-196a-1, mmu-mir-196a-2, mmu-mir-21a, rno-mir-329, mmu-mir-329, mmu-mir-1a-2, mmu-mir-181a-1, mmu-mir-181b-1, mmu-mir-181c, mmu-mir-375, mmu-mir-379, mmu-mir-181b-2, rno-mir-21, rno-mir-127, rno-mir-134, rno-mir-136, rno-mir-143, rno-mir-154, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-196a, rno-mir-181a-1, mmu-mir-196b, rno-mir-196b-1, mmu-mir-412, mmu-mir-370, oar-mir-431, oar-mir-127, oar-mir-432, oar-mir-136, mmu-mir-431, mmu-mir-433, rno-mir-431, rno-mir-433, ssc-mir-181b-2, ssc-mir-181c, ssc-mir-136, ssc-mir-196a-2, ssc-mir-21, rno-mir-370, rno-mir-412, rno-mir-1, mmu-mir-485, mmu-mir-541, rno-mir-541, rno-mir-493, rno-mir-379, rno-mir-485, mmu-mir-668, bta-mir-21, bta-mir-181a-2, bta-mir-127, bta-mir-181b-2, bta-mir-181c, mmu-mir-181d, mmu-mir-493, rno-mir-196c, rno-mir-375, mmu-mir-1b, bta-mir-1-2, bta-mir-1-1, bta-mir-134, bta-mir-136, bta-mir-143, bta-mir-154a, bta-mir-181d, bta-mir-196a-2, bta-mir-196a-1, bta-mir-196b, bta-mir-329a, bta-mir-329b, bta-mir-370, bta-mir-375, bta-mir-379, bta-mir-412, bta-mir-431, bta-mir-432, bta-mir-433, bta-mir-485, bta-mir-493, bta-mir-541, bta-mir-181a-1, bta-mir-181b-1, ssc-mir-1, ssc-mir-181a-1, mmu-mir-432, rno-mir-668, ssc-mir-143, ssc-mir-181a-2, ssc-mir-181b-1, ssc-mir-181d, ssc-mir-196b-1, ssc-mir-127, ssc-mir-432, oar-mir-21, oar-mir-181a-1, oar-mir-493, oar-mir-433, oar-mir-370, oar-mir-379, oar-mir-329b, oar-mir-329a, oar-mir-134, oar-mir-668, oar-mir-485, oar-mir-154a, oar-mir-154b, oar-mir-541, oar-mir-412, mmu-mir-21b, mmu-mir-21c, ssc-mir-196a-1, ssc-mir-196b-2, ssc-mir-370, ssc-mir-493, bta-mir-154c, bta-mir-154b, oar-mir-143, oar-mir-181a-2, chi-mir-1, chi-mir-127, chi-mir-134, chi-mir-136, chi-mir-143, chi-mir-154a, chi-mir-154b, chi-mir-181b, chi-mir-181c, chi-mir-181d, chi-mir-196a, chi-mir-196b, chi-mir-21, chi-mir-329a, chi-mir-329b, chi-mir-379, chi-mir-412, chi-mir-432, chi-mir-433, chi-mir-485, chi-mir-493, rno-mir-196b-2, bta-mir-668, ssc-mir-375
For example, miR-273 and the lys-6 miRNA have been shown to be involved in the development of the nervous system in nematode worm [3]; miR-430 was reported to regulate the brain development of zebrafish [4]; miR-181 controlled the differentiation of mammalian blood cell to B cells [5]; miR-375 regulated mammalian islet cell growth and insulin secretion [6]; miR-143 played a role in adipocyte differentiation [7]; miR-196 was found to be involved in the formation of mammalian limbs [8]; and miR-1 was implicated in cardiac development [9].
[score:6]
[1 to 20 of 1 sentences]
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10 |
[+]
score:
6
Other miRNAs from this paper: rno-mir-31a, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-181a-1, rno-mir-466b-1, rno-mir-466b-2, rno-mir-466c, rno-mir-31b, rno-mir-466d, rno-mir-466b-3, rno-mir-466b-4
The inhibitory effects of miR-466 on Prox1 expression, tube formation, and lymphatic vessel formation were comparable to those of miR-181.
[score:5]
MicroRNA Prox1 miR-466 miR-181 Tube Formation Lymphangiogenesis Cornea transplantation Alkali burn Approximately 10%–50% of cornea transplantation recipients experience graft rejection within one year [1].
[score:1]
[1 to 20 of 2 sentences]
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11 |
[+]
score:
5
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-17, hsa-mir-18a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-20a, hsa-mir-22, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-98, hsa-mir-101-1, hsa-mir-16-2, mmu-let-7g, mmu-let-7i, mmu-mir-1a-1, mmu-mir-15b, mmu-mir-101a, mmu-mir-126a, mmu-mir-130a, mmu-mir-133a-1, mmu-mir-142a, mmu-mir-181a-2, mmu-mir-194-1, hsa-mir-208a, hsa-mir-30c-2, mmu-mir-122, mmu-mir-143, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-181a-1, mmu-let-7d, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-15b, hsa-mir-122, hsa-mir-130a, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-142, hsa-mir-143, hsa-mir-126, hsa-mir-194-1, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-208a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-15a, mmu-mir-16-1, mmu-mir-16-2, mmu-mir-18a, mmu-mir-20a, mmu-mir-22, mmu-mir-26a-1, mmu-mir-26b, mmu-mir-29c, mmu-mir-98, mmu-mir-326, rno-mir-326, rno-let-7d, rno-mir-20a, rno-mir-101b, mmu-mir-101b, hsa-mir-1-1, mmu-mir-1a-2, hsa-mir-181b-2, mmu-mir-17, mmu-mir-19a, mmu-mir-181a-1, mmu-mir-26a-2, mmu-mir-19b-1, mmu-mir-181b-1, mmu-mir-181c, hsa-mir-194-2, mmu-mir-194-2, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-101-2, hsa-mir-26a-2, hsa-mir-378a, mmu-mir-378a, hsa-mir-326, mmu-mir-133a-2, mmu-mir-133b, hsa-mir-133b, mmu-mir-181b-2, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c-1, rno-let-7c-2, rno-let-7e, rno-let-7f-1, rno-let-7f-2, rno-let-7i, rno-mir-15b, rno-mir-16, rno-mir-17-1, rno-mir-18a, rno-mir-19b-1, rno-mir-19a, rno-mir-22, rno-mir-26a, rno-mir-26b, rno-mir-29c-1, rno-mir-30c-1, rno-mir-30c-2, rno-mir-98, rno-mir-101a, rno-mir-122, rno-mir-126a, rno-mir-130a, rno-mir-133a, rno-mir-142, rno-mir-143, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-194-1, rno-mir-194-2, rno-mir-208a, rno-mir-181a-1, hsa-mir-423, hsa-mir-18b, hsa-mir-20b, hsa-mir-451a, mmu-mir-451a, rno-mir-451, ssc-mir-122, ssc-mir-15b, ssc-mir-181b-2, ssc-mir-19a, ssc-mir-20a, ssc-mir-26a, ssc-mir-326, ssc-mir-181c, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-18a, ssc-mir-29c, ssc-mir-30c-2, hsa-mir-484, hsa-mir-181d, hsa-mir-499a, rno-mir-1, rno-mir-133b, mmu-mir-484, mmu-mir-20b, rno-mir-20b, rno-mir-378a, rno-mir-499, hsa-mir-378d-2, mmu-mir-423, mmu-mir-499, mmu-mir-181d, mmu-mir-18b, mmu-mir-208b, hsa-mir-208b, rno-mir-17-2, rno-mir-423, rno-mir-484, mmu-mir-1b, ssc-mir-15a, ssc-mir-16-2, ssc-mir-16-1, ssc-mir-17, ssc-mir-130a, ssc-mir-101-1, ssc-mir-101-2, ssc-mir-133a-1, ssc-mir-1, ssc-mir-181a-1, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-378-1, ssc-mir-133b, ssc-mir-499, ssc-mir-143, ssc-mir-423, ssc-mir-181a-2, ssc-mir-181b-1, ssc-mir-181d, ssc-mir-98, ssc-mir-208b, ssc-mir-142, ssc-mir-19b-1, hsa-mir-378b, ssc-mir-22, rno-mir-126b, rno-mir-208b, rno-mir-133c, hsa-mir-378c, ssc-mir-194b, ssc-mir-133a-2, ssc-mir-484, ssc-mir-30c-1, ssc-mir-126, ssc-mir-378-2, ssc-mir-451, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, mmu-mir-378b, mmu-mir-101c, hsa-mir-451b, hsa-mir-499b, ssc-let-7a-2, ssc-mir-18b, hsa-mir-378j, rno-mir-378b, mmu-mir-133c, mmu-let-7j, mmu-mir-378c, mmu-mir-378d, mmu-mir-451b, ssc-let-7d, ssc-let-7f-2, ssc-mir-20b-1, ssc-mir-20b-2, ssc-mir-194a, mmu-let-7k, mmu-mir-126b, mmu-mir-142b, rno-let-7g, rno-mir-15a, ssc-mir-378b, rno-mir-29c-2, rno-mir-1b, ssc-mir-26b
Our study revealed miR-181 and miR-142-3p with relatively high expression in thymus (Figure 2C), and miR18a and miR-20a appeared to be weakly expressed in thymus (Figure 2D).
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Pathway and signaling pathway analyses demonstrated that miR-181 targets genes encoding antioxidant enzymes, including glutathione peroxidases 1 and 4 (Gpx1 and Gpx4, resp. )
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Hutchison et al. used microarray analysis to assess the effects of miR-181 on the transcriptome in primary astrocytes.
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Other miRNAs from this paper: rno-mir-338, rno-mir-347, rno-mir-7a-1, rno-mir-7a-2, rno-mir-9a-1, rno-mir-9a-3, rno-mir-9a-2, rno-mir-19b-1, rno-mir-19b-2, rno-mir-29a, rno-mir-34c, rno-mir-92a-1, rno-mir-92a-2, rno-mir-93, rno-mir-96, rno-mir-99b, rno-mir-124-3, rno-mir-124-1, rno-mir-124-2, rno-mir-125b-1, rno-mir-125b-2, rno-mir-128-1, rno-mir-128-2, rno-mir-130a, rno-mir-134, rno-mir-137, rno-mir-138-2, rno-mir-138-1, rno-mir-152, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-184, rno-mir-196a, rno-mir-199a, rno-mir-181a-1, rno-mir-219a-1, rno-mir-219a-2, rno-mir-296, rno-mir-449a, rno-mir-433, rno-mir-451, rno-mir-207, rno-mir-1, rno-mir-494, rno-mir-376c, rno-mir-376b, rno-mir-376a, rno-mir-503-1, rno-mir-182, rno-mir-301b, rno-mir-532, rno-mir-742, rno-mir-92b, rno-mir-582, rno-mir-666, rno-mir-344b-2, rno-mir-3559, rno-mir-9b-3, rno-mir-9b-1, rno-mir-9b-2, rno-mir-219b, rno-mir-2985, rno-mir-344b-1, rno-mir-503-2, rno-mir-344b-3
Overall, the expression patterns of miRNAs fell into four main categories: (1) Enriched in early embryonic stages, especially at E10 and E13 and decreased gradually during development (i. e. the rno-miR-181 family); (2) Enriched late postnatally, especially at P14 and P28, and tended to increase over time (i. e. rno-miR-29a and rno-miR-128); (3, 4) Peaked around neonatal stage (P0), either highest peak or lowest peak.
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Other miRNAs from this paper: rno-mir-140, rno-mir-21, rno-mir-30c-1, rno-mir-30e, rno-mir-30b, rno-mir-30d, rno-mir-30a, rno-mir-30c-2, rno-mir-99a, rno-mir-143, rno-mir-145, rno-mir-150, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-210, rno-mir-181a-1, rno-mir-1
Some researchers ever reported that miR-21 and miR-181 were significantly upregulated post-MI [24, 25], which is consistent with our microRNA assay data.
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However, we noticed that unlike the five key miRs we identified neither miR-21 nor miR-181 significantly changed upon SkM treatment post-MI in our study.
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org) revealed several miRNA that might interact with POMC mRNA untranslated region, including miR-488, miR-485, miR-384-3p, miR-383, miR-377, miR-485-5p and miR-181 (family).
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MiR-181b, a member of the miR-181 family, is expressed at intriguingly high levels in the retina and brain areas associated with motor function 29.
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Other miRNAs from this paper: rno-mir-148b, rno-let-7c-1, rno-let-7c-2, rno-let-7i, rno-mir-15b, rno-mir-17-1, rno-mir-21, rno-mir-24-1, rno-mir-24-2, rno-mir-27b, rno-mir-29b-2, rno-mir-29a, rno-mir-29b-1, rno-mir-29c-1, rno-mir-92a-1, rno-mir-92a-2, rno-mir-106b, rno-mir-107, rno-mir-122, rno-mir-125b-1, rno-mir-125b-2, rno-mir-141, rno-mir-143, rno-mir-146a, rno-mir-150, rno-mir-181c, rno-mir-181a-2, rno-mir-192, rno-mir-200c, rno-mir-181a-1, rno-mir-223, rno-mir-320, rno-mir-451, rno-mir-370, rno-mir-17-2, rno-mir-375, rno-mir-146b, rno-mir-29c-2, rno-mir-29b-3
Among miRNAs that were present at higher levels in colostrum whey, let-7i, miR-148b-3p, miR-27b, and miR-125b-3p affect the function of antigen-presenting cells, and miR-15b, miR-24, miR-92a, miR-181a, miR-181c, and miR-181d affect T cell development and function [29], [30], [35].
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On the other hand, other miRNAs such as, let-7i, miR-143, miR-148b-3p, miR-15b, miR-17-5p, miR-24, miR-27b, miR-92a, miR-106b, miR-125b-5p, miR-181a, miR-181c, miR-181d, miR-200c, miR-375, miR-107, miR-141, and miR-370, were present at higher levels in colostrum whey than in mature milk whey (Fig. 6).
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Other miRNAs from this paper: mmu-mir-15b, mmu-mir-23b, mmu-mir-27b, mmu-mir-29b-1, mmu-mir-101a, mmu-mir-138-2, mmu-mir-181a-2, mmu-mir-148a, mmu-mir-192, mmu-mir-15a, mmu-mir-18a, mmu-mir-20a, mmu-mir-23a, mmu-mir-29a, mmu-mir-29c, mmu-mir-27a, mmu-mir-92a-2, rno-mir-20a, rno-mir-101b, mmu-mir-101b, mmu-mir-17, mmu-mir-19a, mmu-mir-181a-1, mmu-mir-29b-2, mmu-mir-19b-1, mmu-mir-92a-1, mmu-mir-138-1, mmu-mir-181b-1, mmu-mir-181c, mmu-mir-181b-2, rno-mir-15b, rno-mir-17-1, rno-mir-18a, rno-mir-19b-1, rno-mir-19a, rno-mir-23a, rno-mir-23b, rno-mir-27b, rno-mir-27a, rno-mir-29b-2, rno-mir-29a, rno-mir-29b-1, rno-mir-29c-1, rno-mir-92a-1, rno-mir-92a-2, rno-mir-101a, rno-mir-138-2, rno-mir-138-1, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-192, rno-mir-181a-1, ssc-mir-148a, ssc-mir-15b, ssc-mir-181b-2, ssc-mir-19a, ssc-mir-20a, ssc-mir-23a, ssc-mir-29b-1, ssc-mir-181c, ssc-mir-27a, ssc-mir-18a, ssc-mir-29c, mmu-mir-181d, rno-mir-17-2, ssc-mir-15a, ssc-mir-17, ssc-mir-101-1, ssc-mir-101-2, ssc-mir-181a-1, ssc-mir-29a, ssc-mir-181a-2, ssc-mir-181b-1, ssc-mir-181d, ssc-mir-27b, ssc-mir-23b, ssc-mir-92a-2, ssc-mir-92a-1, ssc-mir-192, ssc-mir-19b-1, mmu-mir-101c, ssc-mir-29b-2, ssc-mir-138, ssc-mir-194a, rno-mir-148a, rno-mir-15a, rno-mir-29c-2, rno-mir-29b-3
We found that miRNAs with higher expression in WBCs includes different miRNA families: mir-15, mir-17, mir-181, mir-23, mir-27 and mir-29 families.
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Other miRNAs from this paper: rno-mir-329, rno-mir-337, rno-mir-7a-1, rno-mir-7a-2, rno-mir-7b, rno-mir-10a, rno-mir-124-3, rno-mir-124-1, rno-mir-124-2, rno-mir-132, rno-mir-133a, rno-mir-136, rno-mir-144, rno-mir-146a, rno-mir-153, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-206, rno-mir-497, rno-mir-551b, rno-mir-203b, rno-mir-3547, rno-mir-216b, rno-mir-3576, rno-mir-702
The potential miRNA targets of rno_circRNA_008964 included rno-miR-216b-5p, rno-miR-181d-5p, rno-miR-337-5p, rno-miR-497-3p, and rno-miR-181b-5p (Fig. 5a).
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Moon J. M. Xu L. Giffard R. G. Inhibition of microRNA-181 reduces forebrain ischemia -induced neuronal lossJ.
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Other miRNAs from this paper: rno-mir-328a, rno-mir-21, rno-mir-23b, rno-mir-138-2, rno-mir-138-1, rno-mir-191a, rno-mir-200c, rno-mir-214, rno-mir-451, rno-mir-370, rno-mir-20b, rno-mir-499, rno-mir-877, rno-mir-500, rno-mir-3577
Name Primers U6F: 5′-GCTTCGGCAGCACATATACTAAAAT-3′ R: 5′-CGCTTCACGAATTTGCGTGTCAT-3′ rno-miR-500-3pGSP: 5′-GGAAGGCACCTGGGCAAG-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-499-3pGSP: 5′-GGGGAACATCACAGCAAGTC-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-214-3pGSP: 5′-GGGGACAGCAGGCACAGAC-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-20b-5pGSP: 5′-GGGGCAAAGTGCTCATAGTG-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-877GSP: 5′-GGGGAAGTAGAGGAGATGGC-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-451-5pGSP: 5′-GGGGGAAACCGTTACCATTAC-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-3577GSP: 5′-GGGTTCTGTCCCTCTTGGC-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-370-3pGSP: 5′-AGCCTGCTGGGGTGGAA-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-181d-5pGSP: 5′-GGGGCATTCATTGTTGTCG-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-23b-3pGSP: 5′-GGGATCACATTGCCAGGG-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-191a-5pGSP: 5′-GGCAACGGAATCCCAAAAG-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-200c-3pGSP: 5′-GGGGTAATACTGCCGGGTAA-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-328a-3pGSP: 5′-AACTCGCCCTCTCTGCCC-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ nutrients-07-01333-t002_Table 2 Table 2 Primers of mRNA targets.
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Name Primers U6F: 5′-GCTTCGGCAGCACATATACTAAAAT-3′ R: 5′-CGCTTCACGAATTTGCGTGTCAT-3′ rno-miR-500-3pGSP: 5′-GGAAGGCACCTGGGCAAG-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-499-3pGSP: 5′-GGGGAACATCACAGCAAGTC-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-214-3pGSP: 5′-GGGGACAGCAGGCACAGAC-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-20b-5pGSP: 5′-GGGGCAAAGTGCTCATAGTG-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-877GSP: 5′-GGGGAAGTAGAGGAGATGGC-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-451-5pGSP: 5′-GGGGGAAACCGTTACCATTAC-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-3577GSP: 5′-GGGTTCTGTCCCTCTTGGC-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-370-3pGSP: 5′-AGCCTGCTGGGGTGGAA-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-181d-5pGSP: 5′-GGGGCATTCATTGTTGTCG-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-23b-3pGSP: 5′-GGGATCACATTGCCAGGG-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-191a-5pGSP: 5′-GGCAACGGAATCCCAAAAG-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-200c-3pGSP: 5′-GGGGTAATACTGCCGGGTAA-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ rno-miR-328a-3pGSP: 5′-AACTCGCCCTCTCTGCCC-3′ R: 5′-GTGCGTGTCGTGGAGTCG-3′ nutrients-07-01333-t002_Table 2 Table 2 Primers of mRNA targets.
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Other miRNAs from this paper: rno-let-7d, rno-mir-347, rno-mir-129-2, rno-let-7b, rno-mir-22, rno-mir-26b, rno-mir-30a, rno-mir-34b, rno-mir-34c, rno-mir-99b, rno-mir-124-3, rno-mir-124-1, rno-mir-124-2, rno-mir-129-1, rno-mir-134, rno-mir-135a, rno-mir-144, rno-mir-152, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-190a-1, rno-mir-191a, rno-mir-194-1, rno-mir-194-2, rno-mir-199a, rno-mir-212, rno-mir-181a-1, rno-mir-451, rno-mir-383, rno-mir-133b, rno-mir-376c, rno-mir-376b, rno-mir-376a, rno-mir-382, rno-mir-409a, rno-mir-369, rno-mir-874, rno-mir-877, rno-mir-190b, rno-mir-380, rno-mir-708, rno-mir-770, rno-mir-873, rno-mir-504, rno-mir-465, rno-mir-344b-2, rno-mir-191b, rno-mir-409b, rno-mir-702, rno-mir-190a-2
For example, miR-181, miR-124 and let-7d are suggested to be involved in cocaine -induced nervous plasticity and cocaine -induced conditioned place preference (CPP) [7, 8].
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Other miRNAs from this paper: rno-mir-140, rno-mir-21, rno-mir-23a, rno-mir-24-1, rno-mir-24-2, rno-mir-31a, rno-mir-92a-1, rno-mir-92a-2, rno-mir-100, rno-mir-122, rno-mir-125b-1, rno-mir-125b-2, rno-mir-146a, rno-mir-181a-2, rno-mir-181a-1, rno-mir-743b, rno-mir-879, rno-mir-146b, rno-mir-208b
miR-181d-5p.
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Other miRNAs from this paper: cel-let-7, cel-lin-4, hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-17, hsa-mir-29a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-101-1, hsa-mir-29b-1, hsa-mir-29b-2, mmu-let-7g, mmu-let-7i, mmu-mir-29b-1, mmu-mir-101a, mmu-mir-128-1, mmu-mir-9-2, mmu-mir-132, mmu-mir-138-2, mmu-mir-181a-2, mmu-mir-199a-1, hsa-mir-199a-1, hsa-mir-7-1, hsa-mir-7-2, hsa-mir-7-3, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-199a-2, hsa-mir-181a-1, mmu-let-7d, hsa-let-7g, hsa-let-7i, hsa-mir-128-1, hsa-mir-132, hsa-mir-138-2, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-138-1, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-29a, mmu-mir-29c, mmu-mir-92a-2, rno-let-7d, rno-mir-7a-1, rno-mir-101b, mmu-mir-101b, hsa-mir-181b-2, mmu-mir-17, mmu-mir-181a-1, mmu-mir-29b-2, mmu-mir-199a-2, mmu-mir-92a-1, mmu-mir-9-1, mmu-mir-9-3, mmu-mir-138-1, mmu-mir-181b-1, mmu-mir-181c, mmu-mir-128-2, hsa-mir-128-2, mmu-mir-7a-1, mmu-mir-7a-2, mmu-mir-7b, hsa-mir-29c, hsa-mir-101-2, cel-lsy-6, mmu-mir-181b-2, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c-1, rno-let-7c-2, rno-let-7e, rno-let-7f-1, rno-let-7f-2, rno-let-7i, rno-mir-7a-2, rno-mir-7b, rno-mir-9a-1, rno-mir-9a-3, rno-mir-9a-2, rno-mir-17-1, rno-mir-29b-2, rno-mir-29a, rno-mir-29b-1, rno-mir-29c-1, rno-mir-92a-1, rno-mir-92a-2, rno-mir-101a, rno-mir-128-1, rno-mir-128-2, rno-mir-132, rno-mir-138-2, rno-mir-138-1, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-199a, rno-mir-181a-1, rno-mir-421, hsa-mir-181d, hsa-mir-92b, hsa-mir-421, mmu-mir-181d, mmu-mir-421, mmu-mir-92b, rno-mir-17-2, rno-mir-92b, rno-mir-9b-3, rno-mir-9b-1, rno-mir-9b-2, mmu-mir-101c, mmu-let-7j, mmu-let-7k, rno-let-7g, rno-mir-29c-2, rno-mir-29b-3, mmu-mir-9b-2, mmu-mir-9b-1, mmu-mir-9b-3
The mouse microRNA miR-181 has been implicated in the modulation of hematopoietic differentiation, and other mammalian microRNAs have been suggested to play roles in cancer [22, 23].
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Other miRNAs from this paper: rno-let-7c-1, rno-let-7c-2, rno-mir-19b-1, rno-mir-19b-2, rno-mir-19a, rno-mir-22, rno-mir-30c-1, rno-mir-30e, rno-mir-30b, rno-mir-30d, rno-mir-30a, rno-mir-30c-2, rno-mir-99a, rno-mir-99b, rno-mir-100, rno-mir-126a, rno-mir-133a, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-191a, rno-mir-208a, rno-mir-181a-1, rno-mir-1, rno-mir-133b, rno-mir-191b, rno-mir-126b, rno-mir-208b, rno-mir-133c
We found that miR-99, miR-100, miR-208, miR-181, miR-19 and many others were associated to cardiac hypertrophy and apoptosis.
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