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6 publications mentioning rno-mir-760

Open access articles that are associated with the species Rattus norvegicus and mention the gene name mir-760. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 45
Among the nine T-cell miRNAs affected by TNF-α and downregulated in RA T cells, the expression levels of miR-139-3p, miR-204, miR-214, and miR-760 were increased in patients using biologic agents. [score:6]
Each scatter spot representing average normalized expression level of miRNA in three repeats of each treatment; (b) 13 miRNAs exhibiting aberrant expression in Jurkat cells cultured with TNF-α (20 ng/mL) for 7 days; (c) decreased expression of miR-139-3p, miR-204, miR-760, miR-524-5p, miR-136, miR-548d-3p, miR-214, miR-383, and miR-887 in RA T cells miRNA, compared with normal T cells. [score:6]
Initially, our studies showed that among the expression of T cell miRNAs affected by TNF-α in Jurkat cells, the expression levels of miR-139-3p, miR-204, miR-760, miR-383, miR-524-5p, miR-136, miR-548d-3p, and miR-214 were significantly decreased in RA T cells. [score:5]
The expression levels of 12 miRNAs, including miR-139-3p, miR-204, miR-760, miR-432, miR-524-5p, miR-136, miR-548d-3p, miR-206, miR-214, miR-383, miR-224, and miR-887 were significantly lower, whereas the expression level of miR-146a was significantly higher, in Jurkat cells after being cultured with TNF-α for 7 days (fold change > 4, p < 0.05, Fig.   1b). [score:5]
Furthermore, the use of biologic agents in RA patients had a significant 3.66-fold increase (p = 0.015; 95% CI 1.31–10.22) in miR-760 expression levels. [score:3]
The expression levels of miR-760 showed a significant correlation with the use of leflunomide and biologic agents. [score:3]
Expression levels of miR-139-3p, miR-204, miR-214, and miR-760 were correlated with the use of biologic agents. [score:3]
The expression levels of miR-139-3p, miR-204, miR-214, and miR-760 increased in RA patients receiving biologic agents. [score:3]
Decreased expression of miR-139-3p, miR-204, miR-760, miR-524-5p, miR-136, miR-548d-3p, miR-214, miR-383, and miR-887 were noted in RA T cells. [score:3]
The expression levels of miR-139-3p, miR-204, miR-214, and miR-760 increased in RA patients using biologic agents. [score:3]
The fold changes of expression levels for these miRNAs were 0.42-fold for miR-139-3p, 0.43-fold for miR-204, 0.13-fold for miR-760, 0.32-fold for miR-524-5p, 0.45-fold for miR-136, 0.19-fold for miR-548d-3p, 0.37-fold for miR-214;0.36-fold for miR-383, and 0.14-fold for miR-887, compared with controls. [score:2]
The expression of miR-139-3p, miR-204, miR-760, miR-524-5p, miR-136, miR-548d-3p, miR-214, miR-383, and miR-887 was found to be significantly lower in RA T cells (p < 0.05), compared with controls (Fig.   1c). [score:2]
80) 0.65 (0.45– 0.94) – – – – – – 2.44 (1.08– 5.48) miR-383 1.08 (0.77–1.52) 0.71 (0.24–2.09) – – – 0.33 (0.08–1.36) 0.93 (0.82–1.05) – 0.81 (0.60–1.10) – miR-548d-3p 0.80 (0.52–1.22) 0.55 (0.14–2.16) – 0.62 (0.13–2.96) – – – – – – miR-760 0.72 (0. 46–1.11) 0.97 (0.25–3.81) – – – – – 2.54 (0.94–6.90) 1.35 (0.95–1.93) 3.66 (1.31– 10.22) Values shown are fold change (95% confidence interval) calculated using multiple linear regression analysis, and those in bold represent p < 0.05 ACPAs anti-citrullinated protein antibodies, CRP C-reactive protein, miRNA microRNAs, MTX methotrexate, RF rheumatoid factor [a]Biologic agent including: tumor necrosis factor antagonists, abatacept, and tocilizumab Fig. 1Altered expression of T cell miRNAs affected by TNF-α in patients with RA and healthy controls. [score:1]
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2
[+] score: 20
** p < 0.0001 Fig.  2Fold expression of a miR-223, b miR-760 and c miR-145 in nucleus pulposus (NP) tissue frozen directly (native) or 180 min after NP application onto the dorsal nerve roots (exposed) after harvesting. [score:4]
Moreover, the present results demonstrated that miR-223, miR-760 and miR-145 may be up-regulated in NP and released in exosome-like vesicles (ELV) when the NP tissue is exposed to the dorsal nerve roots. [score:4]
Interestingly, miR-223-3p, miR-760-5p and miR-145-5p, were also significantly up-regulated after correction for multiple testing (Fig.   2). [score:4]
Fig.  3Fold expression of a miR-223, b miR-760 and c miR-145 in cell-free medium frozen after nucleus pulposus (NP) incubation for 5 min or 3 h. Overall linear mixed mo del, beta = 0.65, **p < 0.001, 95% CI (0.28, 1.01), nanoparticle tracking analysis, western blot analysis and qPCR were used to demonstrate exosome-like vesicles (ELV) in the media conditioned for 3 h by NP. [score:3]
miR-223-3p, miR760-5p and miR-145-5p were also found in the media fraction (Fig.   3). [score:1]
Representative western blot showing alix, tsg101 and CD-9. d Examples of miR-223, miR-760 and miR-145 qPCR amplification plot in the exosome fraction. [score:1]
Additional qPCR analysis of the ELV samples showed that miR-223-3p, miR760-5p and miR-145-5p were present in the exosome fraction (Fig.   4d). [score:1]
The serum analyses in patients demonstrated a significant decrease in IL-6 (Fig.   5b) and miR-223-3p (Fig.   5c) from inclusion to 12 months (paired Student’s t test, p = 0.005), which was not the case for miR-760-5p and miR-145-5p (data not shown). [score:1]
An increased release of small non-coding RNAs, including miR-223, miR-760 and miR-145, from NP in exosome-like vesicles was demonstrated. [score:1]
[1 to 20 of 9 sentences]
3
[+] score: 15
Other miRNAs from this paper: rno-mir-216a, rno-mir-291a, rno-mir-543, rno-mir-490, rno-mir-291b
Strikingly, we observe recurrent hits on, neutrophin signaling, and ErbB signaling from the predicted targets of miR-18b, miR-291a, miR-760, and miR-367. [score:3]
Two miRNAs, miR-467c and miR-760-5p were observed to increase in expression in both NLH and LH animals relative to control (Fig 4D). [score:3]
0160318.g005 Fig 5Displaying the most significant KEGG pathways predicted to be targeted by the indicated miRNAs for A) miR-18b-5p, B) miR-291-3p, C) miR-760-5p and D) miR-367-3p. [score:3]
Displaying the most significant KEGG pathways predicted to be targeted by the indicated miRNAs for A) miR-18b-5p, B) miR-291-3p, C) miR-760-5p and D) miR-367-3p. [score:3]
Two of these were from the MHb analysis; miR-18b, miR-291a and the other two were from the LHb analysis; miR-760, miR-367. [score:1]
For miR-18b, from the MHb and miR-760 from the LHb it is the highest ranking pathway. [score:1]
miR-760-5p and miR-367-3p were identified in the lateral habenula. [score:1]
[1 to 20 of 7 sentences]
4
[+] score: 4
And 17 miRNAs are downregulated as shown in the lower part of this figure, let-7d, miR-665, miR-125b*, let-7b*, miR-124*, miR-770, miR-383, miR-29b-2*, miR-760-3p, miR-324-3p, miR-135b, miR-21, miR-409-5p, let-7f-1*, miR-28, miR-499*,let-7i* (Table 2). [score:4]
[1 to 20 of 1 sentences]
5
[+] score: 3
miR-186, miR-216b, miR-337-3p, and miR-760 cooperatively induce cellular senescence by targeting α subunit of protein kinase CKII in human colorectal cancer cells. [score:3]
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6
[+] score: 2
Other genes relevant to gene regulation include epigenetic modulators (e. g. Hira, Ehmt2, Yeats2), miRNAs (e. g. Mir138-1, Mir760, Mir301b) and 16 zinc finger transcription factor genes (e. g. Zfp105, Zbtb8a, Zbtb8b, Zdhhc17). [score:2]
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