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45 publications mentioning hsa-mir-548e

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-548e. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 148
Relative expression profiles for genes with hsa-mir-548 target sites were computed for each gene by dividing the gene's tissue-specific expression (signal intensity) values by the gene's median expression value over all 79 tissues and then log [2] normalizing the resulting ratios. [score:9]
Figure S2Over-represented GO biological process categories among genes with miRanda predicted hsa-mir-548 target sites that map to colorectal cancer down-regulated co -expression clusters (i. e. 12, 15 & 20 in Figure 6). [score:8]
Table S3Over-represented GO biological process categories among genes with miRanda predicted hsa-mir-548 target sites that map to colorectal cancer down-regulated co -expression clusters (i. e. 12, 15 & 20 in Figure 6). [score:8]
The apparent connection between cancer and the immune system in our dataset is supported by the similar down-regulated expression patterns seen for hsa-mir-548 target genes among the cancer and immune tissue samples (Figure 7). [score:8]
A dendogram relating the cancer samples based on similarities (differences) among relative expression levels is shown along with the average relative expression levels for all genes with hsa-mir-548 target sites in each of the cancer samples. [score:7]
When the log [2] median expression ratios were averaged for all genes with putative hsa-mir-548 target sites, the colorectal sample had the lowest relative expression level (q = 9.72, v = 12738, k = 6, P<0.001 Tukey test; Figure 8). [score:7]
Representative gene expression profiles for putative hsa-mir-548 target genes from three coexpressed clusters (12, 15 and 20 in Figure 6). [score:7]
0000203.g007 Figure 7Representative gene expression profiles for putative hsa-mir-548 target genes from three coexpressed clusters (12, 15 and 20 in Figure 6). [score:7]
These cases may represent false positive target site predictions or could point to instances where hsa-mir-548 miRNAs act through translational repression and thus do not repress mRNA expression levels. [score:7]
We found 22 examples of putative hsa-mir-548 target genes that were previously found to be related to colorectal cancer based on down-regulation in six separate microarray studies (Table S4). [score:6]
However, a number of genes previously implicated in colorectal cancer etiology by virtue of up-regulation in previous studies were also found to have predicted hsa-mir-548 target sites. [score:6]
If hsa-mir-548 expression is upregulated in colorectal cancer tissue, it may lead to the repression of genes that normally control cellular proliferation. [score:6]
Table S4 Putative hsa-mir-548 target genes previously implicated as being involved in colorectal cancer by microarray expression profiling. [score:5]
Coexpressed clusters of putative hsa-mir-548 target genes. [score:5]
Gene expression profiles for potential hsa-mir-548 targets were taken from the Novartis Research Foundation's Symatlas [34]. [score:5]
We also compared putative hsa-mir-548 target genes to a recently published collection of genes that were indicated as being involved in colorectal cancer by microarray expression profiling [44]. [score:4]
This suggests the possibility that hsa-mir-548 miRNA genes may play some global role related to the regulation of gene expression in cancer. [score:4]
Table S2 Over-represented GO biological process categories among genes with Made1 derived hsa-mir-548 target sites. [score:3]
Comparative genomic sequence data from the UCSC genome browser were used to analyze the relative evolutionary conservation levels for predicted hsa-mir-548 target sites. [score:3]
The hsa-mir-548 mature miRNAs meet both the expression and biogenesis criteria that were articulated to ensure the accurate identification of miRNAs and the distinction between miRNAs and siRNAs [13]. [score:3]
We sought to further evaluate the potential mRNA degradation -based regulatory effects of the hsa-mir-548 miRNAs by searching for down regulation of putative target genes in tissue samples similar to the colorectal samples from which they were cloned [10]. [score:3]
Apparently, Made1 sequences avoid protein coding gene exon regions and thus are poorly represented among potential hsa-mir-548 target sites. [score:3]
Putative hsa-mir-548 target sites were identified using two methods: i-by the modified miRanda algorithm implemented in miRBase and ii-by searching 3′ UTRs for Made1 sequences that are complementary to the mature hsa-mir-548 miRNAs. [score:3]
According to the miRBase predictions, the seven hsa-mir-548 genes have 3,527 potential target genes. [score:3]
GO biological process terms over-represented among the set of genes with Made1 derived hsa-mir-548 target sites. [score:3]
This finding is consistent with the fact that the hsa-mir-548 genes were isolated from colorectal cancer samples, and points to an additional more specific role for these genes in colorectal cancer related gene regulation. [score:2]
Regulatory effects of hsa-mir-548. [score:2]
We sought to characterize the potential regulatory and functional effects of hsa-mir-548 miRNAs by analyzing the genes that they are predicted to target. [score:2]
Made1 and hsa-mir-548 sequences were aligned to each other using the program ClustalW [27]. [score:1]
In particular, the mature hsa-mir-548 miRNAs are all 22nt in length, they were identified from a cDNA library made of size fractionated RNA and they map precisely to genomic regions that are predicted to form local hairpin structures. [score:1]
Made1 elements emerged along the primate evolutionary lineage, and orthologous hsa-mir-548 sequences are confined to the human, chimpanzee and rhesus macaque genome sequences (Figure S3). [score:1]
Interestingly, Made1 transcripts destined to become hsa-mir-548 miRNAs are generated from both strands of the element (Figure 1). [score:1]
Human genomic regions corresponding to Made1-derived miRNA genes are shown: A hsa-mir-548a-1, B hsa-mir-548-a2, C hsa-mir-548-a3, D hsa-mir-548-b, E hsa-mir-548-c, F-hsa-mir-548-d1, G-hsa-mir-548-d2. [score:1]
Individual hsa-mir-548 sequences were queried against the human genome sequence to search for duplicates. [score:1]
The hsa-mir-548 genes were characterized by virtue of their expression in colorectal cancer cell lines and tissue samples [10]. [score:1]
Multiple sequence alignment of Made1 and hsa-mir-548 genes. [score:1]
The palindromic structure of the Made1 elements from which the hsa-mir-548 miRNA genes originated, together with their insertion into transcriptionally active genomic regions, points to a specific mechanism by which these sequences can be recognized and processed by the enzymatic machinery that yields mature miRNA sequences. [score:1]
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2
[+] score: 103
Other miRNAs from this paper: hsa-mir-937
These data suggest that miR-548e targets 3′-UTR of IκB mRNA to inhibit its protein translation. [score:7]
Using synovial fibroblasts, we found that miR-548e targets the 3′-UTR of IκB mRNA to inhibit its translation. [score:7]
MiR-548e targets 3′-UTR of IκB mRNA to inhibit its expression in synovial fibroblasts. [score:6]
MiR-548e targets 3′-UTR of IκB mRNA to inhibit its translation in synovial fibroblasts. [score:6]
Together, these data suggest that MSC transplantation may alleviate experimental RA through suppressing miR-548e -mediated IκB inhibition. [score:5]
First, expression of miR-548e in the joints of MSC-grafted CIA-mice, which antagonized the suppression of miR-548e in synovial fibroblasts by MSCs, abolished all the therapeutic effects of MSCs on CIA severity. [score:5]
These data strongly suggest that MSC transplantation may alleviate experimental RA at least partially through suppressing miR-548e -mediated IκB inhibition. [score:5]
Since miRNAs play a key role in the translational control of genes, we screened IκB targeting miRNAs, and specifically found that miR-548e levels in synovial fibroblasts were altered by MSC transplantation. [score:5]
MSCs may suppress miR-548e in synovial fibroblasts through TGFβ receptor signaling. [score:3]
These data suggest a mo del in which MSCs produce and secrete TGFβ1, which activates the TGFβ receptor in synovial fibroblasts 43, leading to the suppression of miR-548e and, subsequently, increases in IκB levels and decreases in NF-κB levels. [score:3]
Since TGFβ1 is a well-known growth factor that is produced and secreted by MSCs, and since TGFβ1 levels are significantly increased in CIA-mouse joints after MSC transplantation, we hypothesized that MSCs may suppress miR-548e levels in synovial fibroblasts through TGFβ receptor signaling. [score:3]
MSCs suppress miR-548e in synovial fibroblasts through TGFβ receptor signaling. [score:3]
The target sequence was inserted into a pGL3-Basic vector (Promega, Madison, WI, USA) to obtain pGL3-IκB-3′ UTR, which contained the miR-548e binding sequence (IκB-3′ UTR sequence). [score:3]
Moreover, by challenging isolated synovial fibroblasts with TGFβ1 with or without its receptor inhibitor 42, we found that TGFβ1 alone mimicked the effects of MSCs on the changes observed in miR-548e and NF-κB/IκB levels in synovial fibroblasts. [score:3]
Second, expression of as-miR-548e alone in CIA-mice, which decreased miR-548e in synovial fibroblasts, mimicked the effects of MSC transplantation without the need for MSCs. [score:3]
N = 5. (A) Bioinformatics analyses of IκB target sequence, showing that miR-548e binds to 3′-UTR of IκB mRNA at 50 [th]–56 [th] base site. [score:3]
We found that the luciferase activities in miR-548e -depleted cells were significantly higher than the control, while the luciferase activities in miR-548e -overexpressing cells were significantly lower than the control (Fig. 4D). [score:3]
Overexpression of miR-548e abolishes the therapeutic effects of MSCs on CIA. [score:3]
We found that overexpression of miR-548e in synovial fibroblasts abolished the therapeutic effects of MSCs on CIA, based on analyses of paw thickness (Fig. 6C), clinical arthritis score (Fig. 6D) and histological arthritis score (Fig. 6E). [score:3]
We found that expression of as-miR-548e alone, without the need for MSC transplantation, mimicked the therapeutic effects of MSCs on CIA, based on analyses of paw thickness (Fig. 7C), clinical arthritis score (Fig. 7D) and histological arthritis score (Fig. 7E). [score:3]
Inhibition of miR-548e alone mimics the therapeutic effects of MSCs on CIA. [score:3]
We found that TGFβ1 decreased miR-548e levels in synovial fibroblasts, an effect which was abolished by SB431542 (Fig. 5A). [score:1]
miR-548e -modified fibroblasts were seeded in 24-well plates for 24 hours, after which they were transfected with 1 μg of Luciferase-reporter plasmids per well using PEI Transfection Reagent. [score:1]
Finally, we performed another two in vivo experiments to confirm the importance of miR-548e to the therapeutic effects of MSCs on CIA-mice. [score:1]
Next, we co-transplanted AAV-miR-548e with MSCs and examined the effects in CIA-mice (Fig. 6A). [score:1]
First, the effects of AAV-as-miR-548e on miR-548e levels in synovial fibroblasts were confirmed (Fig. 7B). [score:1]
Modulation of miR-548e levels in these cells was confirmed by RT-qPCR (Fig. 4C). [score:1]
AAVs were produced by co-transfecting HEK293 cells with the prepared pAAV-CMVp-miR-548e/pAAV-CMVp-as-miR-548e/pAAV-CMVp-Null plasmids, R2C8 (containing AAV2 Rep and AAV8 capsid genes) and plAd5 (containing adenovirus helper genes) by Lipofectamine 2000 (Invitrogen, St. [score:1]
Modulation of miR-548e levels in synovial fibroblasts was confirmed by RT-qPCR. [score:1]
N = 5. (A) We injected AAV-as-miR-548e viruses into CIA-mice, and examined the effects on CIA severity. [score:1]
Finally, we injected AAV-as-miR-548e viruses into CIA-mice and examined the effects on CIA severity (Fig. 7A). [score:1]
Preparation of AAV-miR-548e, AAV-as-miR548e and AAV -null. [score:1]
Then, these miR-548e -modified cells were transfected with 1 μg IκB-3′-UTR Luciferase-reporter plasmid. [score:1]
The sequence for the as-miR-548e construct is 5′-UGCAAAAGUAGUCUCAGUUUUU-3′. [score:1]
First, the effects of AAV-miR-548e on miR-548e levels in synovial fibroblasts were confirmed (Fig. 6B). [score:1]
To determine whether the binding of miR-548e to IκB mRNA is functional, we isolated synovial fibroblasts from a healthy human, and transfected the cells with either miR-548e or antisense for miR-548e (as-miR-548e). [score:1]
The sequence for the miR-548e construct is 5′-AAAAACUGAGACUACUUUUGCA-3′. [score:1]
N = 5. (A) We co-transplanted AAV-miR-548e viruses with MSCs, and examined the effects on MSC transplantation in CIA-mice. [score:1]
AAVs (10 [9] AAV-miR-548e or AAV-as-miR-548e viral particles in 100 μl PBS; control: same amount of AAV -null virus in 100 μl PBS) was injected intraperitoneally at together with MSCs (AAV-miR-548e) or alone (AAV-as-miR-548e) (n = 5 per each group). [score:1]
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3
[+] score: 46
Moreover, from a review of the literature, we saw that both miR-483-3p and miR-548e have a broad range of targets (respectively 377 targets and 934 targets, miRDB - miRSearch V3.0), although there is missing evidence in the literature concerning their role in human cancers, especially for miR-548e. [score:7]
Here, for the first time, we report a possible role of miR-548e downregulation in HCC recurrence, with a tumor-suppressor function (like miR-483-3p). [score:6]
This is in line with the observation from Shi et al. that the overexpression of miR-548e inhibits cell proliferation and promotes apoptosis in human breast cancer cell lines [32]. [score:5]
Unfortunately, the recurrence-free survival curve in relation to miR-548e expression was not significant as for miR-483-3p: further prospective studies are needed to validate the expression of miR-548e as a single predictive variable. [score:5]
Based on the statistical analysis performed on the arrays with the ExpressionSuite Software, we selected two promising miRNAs for the validation phase: miR-483-3p and miR-548(e) (also named miR-548e-3p). [score:3]
In order to study the significance of miR-483-3p and miR-548e expression in recurrence-free survival of the 20 prospectively enrolled patients of group C, we elaborated an ROC curve to find a cut-off value. [score:3]
miR-548(e) was also significantly down-regulated in recurrent HCC, which showed a mean fold-increase of 0.48±0.92 compared to a mean fold-increase of 16.99±53.85 in non-recurrent HCC (p=0.002). [score:3]
In spite of the high number of targets described, there is a lack of literature concerning the role of miR-548e in HCC. [score:3]
From the miRNA card analysis and the subsequent validation with, two promising miRNAs emerged, with a significant difference in expression between group A (free from recurrence at 5 years) and group B (recurrence after resection): miR-483-3p and miR-548e. [score:3]
Of note, no differences were found in miRNA expression between transplanted and resected HCC from group C: the mean fold increase of miR-483-3p was 6.87±15.36 and 4.63±11.73 in transplanted and resected HCC respectively (p=0.065); the mean fold increase of miR-548(e) was 9.91±27.80 and 38.83±85.99 in transplanted and resected HCC respectively (p=0.165). [score:3]
We therefore decided to validate the expression of these two miRNAs on the whole series (54 patients) by performing single PCR assays to quantify miR-483-3p and miR-548(e) levels. [score:2]
The recurrence-free survival curve built with miR-548e ΔΔCT did not reach statistical significance (data not shown). [score:1]
Single PCR assays confirmed the significant differential expression of miR-483-3p (fold increase 8.18±3.04; p=0.012, Wilcoxon-matched pairs test) and miR-548(e) (fold increase 9.17±39.66; p<0.001) in HCC tissue compared to controls. [score:1]
Quantitative real-time polymerase chain reaction (qRT-PCR) validation for miR-483-3p and miR-548(e). [score:1]
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4
[+] score: 27
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-21, hsa-mir-23a, hsa-mir-27a, hsa-mir-29a, hsa-mir-101-1, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-16-2, hsa-mir-10a, hsa-mir-10b, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-181a-1, hsa-mir-223, hsa-let-7g, hsa-let-7i, hsa-mir-15b, hsa-mir-23b, hsa-mir-27b, hsa-mir-146a, hsa-mir-150, hsa-mir-155, hsa-mir-181b-2, hsa-mir-29c, hsa-mir-101-2, hsa-mir-301a, hsa-mir-378a, hsa-mir-381, hsa-mir-340, hsa-mir-146b, hsa-mir-181d, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-590, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-378d-2, hsa-mir-301b, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-548q, hsa-mir-548s, hsa-mir-378b, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, hsa-mir-378c, hsa-mir-23c, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-378f, hsa-mir-378g, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-378h, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-378i, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-378j, hsa-mir-548ay, hsa-mir-548az, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc
Namely, HHV-6A specifically induced an early up-regulation of miR-590 (1 d. p. i. ), miR-15a and miR-21 (3 d. p. i. ), a sustained up-regulation of miR-29b, miR-101 (3 and 6 d. p. i. ), miR-301a and miR-548e (1 and 6 d. p. i. ) and a late up-regulation of miR-340 and miR-381 (6 d. p. i. ) By contrast, HHV-6B infection specifically up-modulated the expression of miR-301b (2 and 3 d. p. i. ) and miR-548e (1 and 3 d. p. i. ), whereas it down-regulated miR-590 (2 and 3 d. p. i. ) and miR-15a (6 d. p. i. ). [score:15]
In particular, both HHV-6A and 6B induced an early up-regulation of miR-301a and miR-548e (1 d. p. i. ), an increase of miR-101 and a decrease of miR-let-7c and miR-340 at 3 d. p. i., and a down-regulation of miR-23 at late time-points p. i. (6 d. p. i. ). [score:7]
The up-regulated miR-101 and miR-381 are involved in the polarization and activation of the cells of the innate immune compartment, regulating the inflammatory response (Zhu et al., 2010; Essandoh et al., 2016; Wen et al., 2016); the increased miR-548 may represent a mechanism facilitating viral pathogenesis as it negatively correlates with IFNγR1 levels (Xing et al., 2014). [score:5]
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5
[+] score: 27
A) K562 miRNA Host Transcript miRNA:Host transcript Status miR-342 EVL Downregulated miR-548e SHOC2 Downregulated miR-486 ANK1 Upregulated B) HL60 miRNA Host Transcript miRNA:Host transcript Status miR-22 C17orf91 Downregulated miR-151 PTK2 Downregulated miR-199b DNM1 Upregulated miR-25 MCM7 Upregulated miR-618 LIN7A Upregulated The analysis of microarray data revealed induction in the expression of some of the miRNA biogenesis genes (RNASEN, DGCR8, XPO5, RAN) in K562 cell line (Table 3). [score:27]
[1 to 20 of 1 sentences]
6
[+] score: 25
Other miRNAs from this paper: mmu-mir-466a, mmu-mir-467a-1, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-548d-1, hsa-mir-548d-2, mmu-mir-669a-1, mmu-mir-669b, mmu-mir-669a-2, mmu-mir-669a-3, mmu-mir-467b, mmu-mir-669c, mmu-mir-466b-1, mmu-mir-466b-2, mmu-mir-466b-3, mmu-mir-466c-1, mmu-mir-466e, mmu-mir-466f-1, mmu-mir-466f-2, mmu-mir-466f-3, mmu-mir-466g, mmu-mir-466h, mmu-mir-467c, mmu-mir-467d, mmu-mir-466d, mmu-mir-467e, mmu-mir-466l, mmu-mir-669k, mmu-mir-669g, mmu-mir-669d, mmu-mir-466i, mmu-mir-669j, mmu-mir-669f, mmu-mir-669i, mmu-mir-669h, mmu-mir-466f-4, mmu-mir-466k, mmu-mir-467f, mmu-mir-466j, mmu-mir-669e, mmu-mir-467g, mmu-mir-467h, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, mmu-mir-669l, mmu-mir-669m-1, mmu-mir-669m-2, mmu-mir-669o, mmu-mir-669n, hsa-mir-548q, mmu-mir-466m, mmu-mir-669d-2, mmu-mir-466o, mmu-mir-467a-2, mmu-mir-669a-4, mmu-mir-669a-5, mmu-mir-467a-3, mmu-mir-466c-2, mmu-mir-669a-6, mmu-mir-467a-4, mmu-mir-466b-4, mmu-mir-669a-7, mmu-mir-467a-5, mmu-mir-466b-5, mmu-mir-669p-1, mmu-mir-467a-6, mmu-mir-669a-8, mmu-mir-466b-6, mmu-mir-669a-9, mmu-mir-467a-7, mmu-mir-466b-7, mmu-mir-669p-2, mmu-mir-467a-8, mmu-mir-669a-10, mmu-mir-467a-9, mmu-mir-669a-11, mmu-mir-467a-10, mmu-mir-669a-12, mmu-mir-466p, mmu-mir-466n, mmu-mir-466b-8, hsa-mir-548s, hsa-mir-466, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, mmu-mir-466q, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-548ay, hsa-mir-548az, hsa-mir-548ba, hsa-mir-548bb, mmu-mir-466c-3, hsa-mir-548bc
hsa-miR-548, mmu-miR-466, and mmu-miR-467 have an enormous number of targets on IGs, which both have the role of inhibition of host immunity response. [score:5]
UVB irradiations can downregulate hsa-miR-548 of human epidermal melanocytes cell [48]. [score:4]
Both of hsa-miRNA-548 and mmu-miR-466 and mmu-miR-467 can inhibit the host immunity response [54]. [score:3]
The hsa-miR-548 family has predicted 4643 target sites distributed on 541 IGs of the human. [score:3]
We found that the hsa-miR-548 family has the highest amount of target sites among the identified miRNAs in human and the mmu-miR-466 and mmu-miR-467 families are top two in the miRNAs list predicted in the mouse. [score:3]
These results suggested that hsa-miR-548 might contribute to dynamic regulatory network of skin transcriptome of human. [score:2]
miR-548 is a primate-specific miRNA family, which has 69 members distributed in almost all human chromosomes [42]. [score:1]
The hsa-miR-548 family is involved in multiple biological processes, such as signaling pathways, immunity, and osteogenic differentiation, and some cancers [43– 47]. [score:1]
hsa-miR-548 also can turn down the host antiviral response by degradation of IFN-λ1 [43]. [score:1]
The hsa-miR-548 family is wi dely distributed in the whole human genome. [score:1]
hsa-miR-548 takes part in IFN signaling which responds to the virus and bacterial infections on the cell [46]. [score:1]
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7
[+] score: 24
Li and colleagues demonstrated that miR-548 down-regulates host antiviral response via direct targeting of IFN-λ1 [59]. [score:7]
The use of miR-548 mimics and inhibitors were shown to enhance or inhibit EV71 replication in RD cells respectively [59]. [score:5]
In view that the host innate system is the first line of defence with IFNs being a key player during viral infection, it is atypical that miR-548 was up regulated to down regulate the host immune system [17], [18], [20]– [25]. [score:3]
In particular, our results revealed miR-548 to be significantly up regulated in EV71 infected cells at 36hpi in comparison with control non infected cells. [score:2]
Specifically, our result suggests that EV71 may be at least partially responsible for the up regulation of host miR-548 to enhance cellular microenvironment for viral replication. [score:2]
0102997.g008 Figure 8 EV71 altered host miRNAs such as has-miR-548 to manipulate host antiviral responses such as Toll-like signalling, NOD-like signalling, RIG-1 signalling and Type I interferon pathways to enhance its survival during pathogenesis. [score:1]
EV71 altered host miRNAs such as has-miR-548 to manipulate host antiviral responses such as Toll-like signalling, NOD-like signalling, RIG-1 signalling and Type I interferon pathways to enhance its survival during pathogenesis. [score:1]
Consistent with our findings, Li and colleagues have recently identified the involvement of miR-548 in IFN signalling pathways during viral infection [59]. [score:1]
In contrast, in EV71 infected rhabdomyosarcoma (RD) cells, miR-548 was observed to decrease in a time dependent manner [59]. [score:1]
Further bioinformatics analysis revealed that miR-548 was involved in antiviral response during infection [17], [23], [25], [38], [59]. [score:1]
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8
[+] score: 19
Similarly, hsa-miR-548 also showed significant identity with each of the three viruses: 68% with, 80% with HIV-1, and 88% with HBV, and their importance in HBV or HIV-1 treatment as a therapeutic marker cannot be ruled out as the identity between hsa-miR-548b and hsa-miR-548s and viral target sites is 80% and above (Table 1). [score:3]
The other two miRNAs, hsa-miR- 99 and hsa-miR-548, did show, respectively, 79 and 68% identity with, but their identity with the other two viruses (HIV-1 and HBV) was only significant with other branches of hsa-miRs (Table 1), which may not be important in regulating the viral replications of any of the three viruses. [score:2]
The hsa-miR-122 was named miravirsen by California based Santaris Pharma, which initiated the trials in 2009. hsa-miRs: −99 and −548 identity with, HIV-1, and HBVThe other two miRNAs, hsa-miR- 99 and hsa-miR-548, did show, respectively, 79 and 68% identity with, but their identity with the other two viruses (HIV-1 and HBV) was only significant with other branches of hsa-miRs (Table 1), which may not be important in regulating the viral replications of any of the three viruses. [score:2]
Furthermore, miR-548 may be an alternate therapeutics agent in TI and HIV-1 HBV dual infected patients. [score:1]
They detected 69 human mir-548 genes located in almost all human chromosomes whose widespread distribution pattern implicates the evolutionary origin from transposable elements. [score:1]
On the contrary, hsa-miR-548 showed 68, 80, and 88% identities with, HIV-1, and HBV, respectively, and 100% identities at the seed sequence with the other two viruses (HIV-1 and HBV), which make it an important anti-TI miRNA, in particular, when it showed significant identities to HIV-1 and HBV (i. e. 80 and 88%, respectively). [score:1]
On the contrary, HBV may enhance HIV-1 replication by activating HIV long terminal repeat with X protein (HBX) and cause immune activation in synergy with HIV-1. Liang et al. (34) have carried out a genome-wide analysis of hsa-miR-548 and have shown that this miRNA belongs to a larger, poorly conserved primate-specific miRNA gene family. [score:1]
On the contrary, HBV may enhance HIV-1 replication by activating HIV long terminal repeat with X protein (HBX) and cause immune activation in synergy with HIV-1. Liang et al. (34) have carried out a genome-wide analysis of hsa-miR-548 and have shown that this miRNA belongs to a larger, poorly conserved primate-specific miRNA gene family. [score:1]
As summarized in Table 1, we also show that three hsa-miRs (miR-3065-3p, miR-99, and miR-548) exhibited a significant mutual identity to genomic sequences of these three viruses. [score:1]
Furthermore, miR-548 showed perfect alignment at the first four bases of the seed sequences, making it a significant anti-TI therapeutic miRNA. [score:1]
Therefore, this is the first report where we are presenting potential use of miR-548 as a therapeutic agent in TI. [score:1]
Here, we present evidence using essential components of bioinformatics tools, and hypothesize that utility of hsa-miR-3065-3p and perhaps miR-548 would be potential antiviral therapeutic agents in the treatment of TI patients because it shows near perfect alignment in the seed region for all three viruses. [score:1]
In addition, hsa-miR-99, hsa-miR-548, and hsa-miR-122 also showed mutual identity with these three viral genomes, albeit at a lower degree (∼52–88%). [score:1]
The location of mir-548 gene family members is detected in all human chromosomes except chromosomes 19 and Y and over 30% of the members are located in chromosomes 6, 8, and X. Furthermore, functionally miR-548 miRNAs are linked to various signaling pathways, including MARK, Wnt insulin, calcium, and p53 signaling pathways as well as to various cancers, including melanoma, colorectal, renal, small cell lung cancer, and glioma. [score:1]
The main focus of this study is hsa-miR-3065-3p and not hsa-miR-122, hsa-miR-99, or has-miR-548. [score:1]
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9
[+] score: 18
These data support that miR-1279, miR-548j, miR-548 m, and miR-548d-5p may potentially regulate PTPN12 gene expression. [score:4]
Interactions between PTPN12, MSH6, and ZEB1 mRNAs and miR-1279, as well as interactions between PTPN12 mRNA and miR-548j, miR-548 m, and miR-548d-5p correspond to different open reading frames in their mRNA targets. [score:3]
Consequently, the effect of miR-548 m on PTPN12 mRNA expression was less than those of miR-1279 and miR-548j. [score:3]
PTPN12 mRNA contained near perfect binding sites for several miRNAs (miR-1279, miR-548j, and miR-548 m). [score:1]
Features of hsa-miR-548j Binding Sites in mRNAs of PTPN12 Orthologous Genes PTPN12 mRNA contained near perfect binding sites for several miRNAs (miR-1279, miR-548j, and miR-548 m). [score:1]
The third miRNA that binds to PTPN12 mRNA was miR-548 m. This binding site showed a lower level of conservation than miR-1279 and miR-548j binding sites. [score:1]
As shown in Table 7, miR-548 m and miR-548d-5p interacted predominantly with the 3′-end and, in several cases, the central region (A. carolinensis, C. jacchus, Gallus gallus, M. gallopavo, O. niloticus, and P. abelii). [score:1]
The Δ G [m] value of miR-548 m with a perfectly complementary sequence equalled −139.4 kJ/moL. [score:1]
In present work we analysed the conservation of miR-1279, miR-548 m, miR-548j and miR-548d-5p binding sites inorthologues and paralogues of the PTPN12, MSH6 and ZEB1 genes to verify these interactions. [score:1]
The binding energy of this site was lower than in the miR-548j and miR-548 m binding sites, but the nucleotide sequence in this site exhibited conservation in orthologous genes (Table 6). [score:1]
Nucleotide sequence of hsa-miR-1279, hsa-miR-548 m, and hsa-miR-548j were received from miRBase (http://www. [score:1]
[1 to 20 of 11 sentences]
10
[+] score: 11
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-17, hsa-mir-20a, hsa-mir-21, hsa-mir-28, hsa-mir-29a, hsa-mir-93, hsa-mir-100, hsa-mir-101-1, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-107, hsa-mir-16-2, hsa-mir-196a-1, hsa-mir-199a-1, hsa-mir-148a, hsa-mir-34a, hsa-mir-181c, hsa-mir-182, hsa-mir-196a-2, hsa-mir-199a-2, hsa-mir-210, hsa-mir-217, hsa-mir-223, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-15b, hsa-mir-27b, hsa-mir-122, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-125b-1, hsa-mir-130a, hsa-mir-132, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-137, hsa-mir-138-2, hsa-mir-141, hsa-mir-152, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-134, hsa-mir-138-1, hsa-mir-146a, hsa-mir-150, hsa-mir-200c, hsa-mir-1-1, hsa-mir-155, hsa-mir-106b, hsa-mir-29c, hsa-mir-101-2, hsa-mir-34b, hsa-mir-34c, hsa-mir-372, hsa-mir-382, hsa-mir-148b, hsa-mir-196b, hsa-mir-424, hsa-mir-448, hsa-mir-449a, hsa-mir-483, hsa-mir-491, hsa-mir-501, hsa-mir-503, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-320c-1, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-320c-2, hsa-mir-548q, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-548ay, hsa-mir-548az, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc
miR-155 by up-regulation of IFN-inducible genes suppresses HBV disease progression, whereas miR-548 by down-regulation of the host anti-viral response promotes HBV progression [46]. [score:11]
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11
[+] score: 10
Other miRNAs from this paper: hsa-let-7b, hsa-mir-21, hsa-mir-27a, hsa-mir-148a, hsa-mir-10a, hsa-mir-10b, hsa-mir-34a, hsa-mir-203a, hsa-mir-1-2, hsa-mir-23b, hsa-mir-122, hsa-mir-141, hsa-mir-126, hsa-mir-146a, hsa-mir-1-1, hsa-mir-155, hsa-mir-34b, hsa-mir-34c, hsa-mir-296, hsa-mir-370, hsa-mir-373, hsa-mir-342, hsa-mir-526a-1, hsa-mir-526a-2, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-542, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-1246, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-548q, hsa-mir-548s, hsa-mir-466, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-203b, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-548ay, hsa-mir-548az, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc
In addition, miRNA-548 mimics present an inhibitory effect on IFNλ1 by targeting its 3′ UTR to regulate the IFNλ1 -mediated antiviral response [73]. [score:6]
Li et al. [73] highlighted miR-548 as downregulated in both Vesicular stomatitis virus and EV71 infections, whereas hosts might establish an antiviral response. [score:4]
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12
[+] score: 8
This could be attributable to off -targeting given the modest expression of miR-548d during H1N1 infection (Table SA5 from [50]), and the significant “seed identity” between the 68 members of the miR-548 family (Text S1). [score:5]
Text S1 Alignment of miR-548 family miRNA sequences. [score:1]
Sequences of miR-548 family members were aligned using Clustal W application locally in BioEdit ver. [score:1]
Alignment shows high degree of seed identity between multiple miR-548 members. [score:1]
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13
[+] score: 8
For the efficient target NTRK2, miR-548-5b repressed it only in CIN I stage, and it had contribution to the processes of ‘positive regulation of axonogenesis’, ‘regulation of Rac GTPase activity’, and ‘regulation of protein kinase B signaling’ only in normal stage. [score:6]
Our finding suggests that through miR-548-5b’s differential regulation on NTRK2, cell differentiation may be impaired in CIN I stage, thus leading cell to the poorly differentiated carcinogenesis transformation. [score:2]
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14
[+] score: 7
Furthermore, Li et al (22) demonstrated that the members of the miRNA-548 family, including miR-548b-5p, miR-548c-5p, miR-548i, miR-548j and miR-548n, downregulate the host antiviral response during EV71 or vesicular stomatitis virus infection via direct targeting of interferon-λ1. [score:7]
[1 to 20 of 1 sentences]
15
[+] score: 5
The research results of Li et al. suggested that miRNA-548 regulates host antiviral response via direct targeting of IFN-λ1 [14]. [score:5]
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16
[+] score: 5
The expression date and high sequence identities strongly support the proposed TE origin of several hsa-mir-548 family members. [score:3]
As RNAi-related enzymes can recognize this type of imperfect stem-loop and process it into the 22 bp mature miRNA sequences, the authors proposed that Made1 TE transcripts are processed into hsa-mir-548 miRNAs. [score:1]
A correlation was observed, and nt sequence comparisons showed a high identity between seven members of the family of miRNAs hsa-mir-548 and the miniature inverted repeat transposable element (MITE), Made1. [score:1]
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17
[+] score: 4
Other miRNAs from this paper: hsa-mir-17, hsa-mir-19a, hsa-mir-29a, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-198, hsa-mir-208a, hsa-mir-10a, hsa-mir-223, hsa-mir-122, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-125b-1, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125b-2, hsa-mir-126, hsa-mir-146a, hsa-mir-150, hsa-mir-155, hsa-mir-29c, hsa-mir-99b, hsa-mir-296, hsa-mir-196b, hsa-mir-515-1, hsa-mir-515-2, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-550a-1, hsa-mir-550a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-640, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-550a-3, bta-mir-29a, bta-mir-125b-1, bta-mir-126, bta-mir-10a, bta-mir-124a-1, bta-mir-17, bta-mir-29b-2, bta-mir-29c, bta-mir-150, bta-mir-122, bta-mir-125b-2, bta-mir-19a, bta-mir-99b, hsa-mir-208b, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, bta-mir-124a-2, bta-mir-124b, bta-mir-146a, bta-mir-155, bta-mir-196b, bta-mir-208a, bta-mir-208b, bta-mir-223, bta-mir-296, bta-mir-29d, bta-mir-9-1, bta-mir-9-2, bta-mir-29e, bta-mir-29b-1, hsa-mir-548q, bta-mir-2284i, bta-mir-2285a, bta-mir-2284s, bta-mir-2285d, bta-mir-2284l, bta-mir-2284j, bta-mir-2284t, bta-mir-2285b-1, bta-mir-2284d, bta-mir-2284n, bta-mir-2284g, bta-mir-2284p, bta-mir-2284u, bta-mir-2284f, bta-mir-2284a, bta-mir-2284k, bta-mir-2284c, bta-mir-2284v, bta-mir-2285c, bta-mir-2284q, bta-mir-2284m, bta-mir-2284b, bta-mir-2284r, bta-mir-2284h, bta-mir-2284o, bta-mir-2284e, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, bta-mir-2284w, bta-mir-2284x, hsa-mir-548y, hsa-mir-550b-1, hsa-mir-550b-2, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, bta-mir-2284y-1, bta-mir-2285e-1, bta-mir-2285e-2, bta-mir-2285f-1, bta-mir-2285f-2, bta-mir-2285g-1, bta-mir-2285h, bta-mir-2285i, bta-mir-2285j-1, bta-mir-2285j-2, bta-mir-2285k-1, bta-mir-2285l, hsa-mir-548ay, hsa-mir-548az, bta-mir-2285o-1, bta-mir-2285o-2, bta-mir-2285n-1, bta-mir-2285n-2, bta-mir-2285p, bta-mir-2285m-1, bta-mir-2285m-2, bta-mir-2284y-2, bta-mir-2285n-3, bta-mir-2285n-4, bta-mir-2284y-3, bta-mir-2285o-3, bta-mir-2285o-4, bta-mir-2285m-3, bta-mir-2284y-4, bta-mir-2284y-5, bta-mir-2284y-6, bta-mir-2285m-4, bta-mir-2285o-5, bta-mir-2285m-5, bta-mir-2285n-5, bta-mir-2285n-6, bta-mir-2284y-7, bta-mir-2285n-7, bta-mir-2284z-1, bta-mir-2284aa-1, bta-mir-2285k-2, bta-mir-2284z-3, bta-mir-2284aa-2, bta-mir-2284aa-3, bta-mir-2285k-3, bta-mir-2285k-4, bta-mir-2284z-4, bta-mir-2285k-5, bta-mir-2284z-5, bta-mir-2284z-6, bta-mir-2284z-7, bta-mir-2284aa-4, bta-mir-2285q, bta-mir-2285r, bta-mir-2285s, bta-mir-2285t, bta-mir-2285b-2, bta-mir-2285v, bta-mir-2284z-2, bta-mir-2285g-2, bta-mir-2285g-3, bta-mir-2285af-1, bta-mir-2285af-2, bta-mir-2285y, bta-mir-2285w, bta-mir-2285x, bta-mir-2285z, bta-mir-2285u, bta-mir-2285aa, bta-mir-2285ab, bta-mir-2284ab, bta-mir-2285ac, bta-mir-2285ad, bta-mir-2284ac, bta-mir-2285ae, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc, bta-mir-2285ag, bta-mir-2285ah, bta-mir-2285ai, bta-mir-2285aj, bta-mir-2285ak, bta-mir-2285al, bta-mir-2285am, bta-mir-2285ar, bta-mir-2285as-1, bta-mir-2285as-2, bta-mir-2285as-3, bta-mir-2285at-1, bta-mir-2285at-2, bta-mir-2285at-3, bta-mir-2285at-4, bta-mir-2285au, bta-mir-2285av, bta-mir-2285aw, bta-mir-2285ax-1, bta-mir-2285ax-2, bta-mir-2285ax-3, bta-mir-2285ay, bta-mir-2285az, bta-mir-2285an, bta-mir-2285ao-1, bta-mir-2285ao-2, bta-mir-2285ap, bta-mir-2285ao-3, bta-mir-2285aq-1, bta-mir-2285aq-2, bta-mir-2285ba-1, bta-mir-2285ba-2, bta-mir-2285bb, bta-mir-2285bc, bta-mir-2285bd, bta-mir-2285be, bta-mir-2285bf-1, bta-mir-2285bf-2, bta-mir-2285bf-3, bta-mir-2285bg, bta-mir-2285bh, bta-mir-2285bi-1, bta-mir-2285bi-2, bta-mir-2285bj-1, bta-mir-2285bj-2, bta-mir-2285bk, bta-mir-2285bl, bta-mir-2285bm, bta-mir-2285bn, bta-mir-2285bo, bta-mir-2285bp, bta-mir-2285bq, bta-mir-2285br, bta-mir-2285bs, bta-mir-2285bt, bta-mir-2285bu-1, bta-mir-2285bu-2, bta-mir-2285bv, bta-mir-2285bw, bta-mir-2285bx, bta-mir-2285by, bta-mir-2285bz, bta-mir-2285ca, bta-mir-2285cb, bta-mir-2285cc, bta-mir-2285cd, bta-mir-2285ce, bta-mir-2285cf, bta-mir-2285cg, bta-mir-2285ch, bta-mir-2285ci, bta-mir-2285cj, bta-mir-2285ck, bta-mir-2285cl, bta-mir-2285cm, bta-mir-2285cn, bta-mir-2285co, bta-mir-2285cp, bta-mir-2285cq, bta-mir-2285cr-1, bta-mir-2285cr-2, bta-mir-2285cs, bta-mir-2285ct, bta-mir-2285cu, bta-mir-2285cv-1, bta-mir-2285cv-2, bta-mir-2285cw-1, bta-mir-2285cw-2, bta-mir-2285cx, bta-mir-2285cy, bta-mir-2285cz, bta-mir-2285da, bta-mir-2285db, bta-mir-2285dc, bta-mir-2285dd, bta-mir-2285de, bta-mir-2285df, bta-mir-2285dg, bta-mir-2285dh, bta-mir-2285di, bta-mir-2285dj, bta-mir-2285dk, bta-mir-2285dl-1, bta-mir-2285dl-2, bta-mir-2285dm
The miR-548 family comprises of over 70 miRNAs whose expression to date has only been described in simians. [score:3]
These include the majority of miRNAs numbered from miR-550 to miR-640; some 200 miRNAs, which include the hsa-miR-515 cluster (11 miRNAs), and interestingly, the miR-548 family. [score:1]
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18
[+] score: 4
Other miRNAs from this paper: hsa-let-7b, hsa-mir-15a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-27a, hsa-mir-28, hsa-mir-30a, hsa-mir-100, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-181a-2, hsa-mir-210, hsa-mir-181a-1, hsa-mir-221, hsa-mir-1-2, hsa-mir-15b, hsa-mir-30b, hsa-mir-122, hsa-mir-132, hsa-mir-141, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-195, hsa-mir-200c, hsa-mir-1-1, hsa-mir-30c-1, hsa-mir-34b, hsa-mir-34c, hsa-mir-30e, hsa-mir-371a, hsa-mir-372, hsa-mir-373, hsa-mir-375, hsa-mir-151a, hsa-mir-429, hsa-mir-449a, hsa-mir-483, hsa-mir-193b, hsa-mir-520e, hsa-mir-520f, hsa-mir-520a, hsa-mir-520b, hsa-mir-520c, hsa-mir-520d, hsa-mir-520g, hsa-mir-520h, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-449b, hsa-mir-151b, hsa-mir-320b-1, hsa-mir-320b-2, hsa-mir-891a, hsa-mir-935, hsa-mir-1233-1, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-1275, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-1973, hsa-mir-548q, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, hsa-mir-1233-2, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-371b, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-548ay, hsa-mir-548az, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc
These miRNAs are expressed in spermatozoa and are involved in spermatogenesis (hsa-miR-34b-3p, hsa-miR-27a), embryonic development (hsa-miR-520 family) or in signaling pathways and human tumorigenesis (hsa-miR-548 family). [score:4]
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[+] score: 4
Copy number in miR548 K (region 11q13) is higher in sensitive cell lines (Mann Whitney test, P=0.0421) A. Enrichment scores for EGS, IGS, LGS and PGS were computed in 22 head and neck, 23 esophageal SCC and 6 SCC of the lung and correlated with the half maximal inhibitory concentration (IC [50]) of 98 drugs, downloaded from the GDSC [24]. [score:3]
Copy number in miR548 K (region 11q13) is higher in sensitive cell lines (Mann Whitney test, P=0.0421) Finally, we tested whether patients with OPL (oral premalignant lesions) enriched for 4-NQO derived gene subsets were at higher risk of developing OSCC. [score:1]
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[+] score: 3
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-17, hsa-mir-19a, hsa-mir-21, hsa-mir-31, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-105-1, hsa-mir-105-2, hsa-mir-199a-1, hsa-mir-34a, hsa-mir-187, hsa-mir-199a-2, hsa-mir-205, hsa-mir-214, hsa-mir-221, hsa-let-7g, hsa-let-7i, hsa-mir-128-1, hsa-mir-141, hsa-mir-144, hsa-mir-145, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-146a, hsa-mir-200c, hsa-mir-128-2, hsa-mir-29c, hsa-mir-376a-1, hsa-mir-378a, hsa-mir-133b, hsa-mir-429, hsa-mir-487a, hsa-mir-515-1, hsa-mir-515-2, hsa-mir-526b, hsa-mir-514a-1, hsa-mir-514a-2, hsa-mir-514a-3, hsa-mir-376a-2, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-656, hsa-mir-542, hsa-mir-378d-2, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-1275, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-2114, hsa-mir-548q, hsa-mir-548s, hsa-mir-378b, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, hsa-mir-514b, hsa-mir-378c, hsa-mir-4303, hsa-mir-4309, hsa-mir-4307, hsa-mir-4278, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-378f, hsa-mir-378g, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-378h, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-378i, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-378j, hsa-mir-548ay, hsa-mir-548az, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc
The expression level of miR-214* is increased 3.79-fold (Figure 4(a)), miR-105 is increased 16.32-fold (Figure 4(b)), has-miR-548 is 4.21-fold (Figure 4(c)), and miR-514 is increased 11.76-fold (Figure 4(d)) in comparing with normal tissues. [score:3]
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[+] score: 3
Moreover, Yan et al. showed that expression of as-miR-548e recapitulated the effects of MSCs on collagen -induced mouse arthritis, likely through reactivation of IkappaB [25]. [score:3]
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[+] score: 3
In the main study plasma from the 77 subjects were analysed for expression of 12 miRNAs (let-7a, let-7f, miR-19a, miR-22, miR26a, miR28-5p, miR-99b, miR151-5p, miR-221, miR-532-3p, miR-548-3p, miR-766). [score:3]
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[+] score: 3
Other miRNAs from this paper: hsa-mir-25, hsa-mir-28, hsa-mir-95, mmu-mir-151, mmu-mir-290a, mmu-mir-297a-1, mmu-mir-297a-2, mmu-mir-130b, mmu-mir-340, mmu-mir-25, mmu-mir-28a, hsa-mir-130b, hsa-mir-367, hsa-mir-372, hsa-mir-378a, mmu-mir-378a, hsa-mir-340, hsa-mir-151a, mmu-mir-466a, mmu-mir-467a-1, hsa-mir-505, hsa-mir-506, mmu-mir-367, hsa-mir-92b, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-648, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-659, hsa-mir-421, hsa-mir-151b, hsa-mir-1271, hsa-mir-378d-2, mmu-mir-467b, mmu-mir-297b, mmu-mir-505, mmu-mir-297a-3, mmu-mir-297a-4, mmu-mir-297c, mmu-mir-421, mmu-mir-466b-1, mmu-mir-466b-2, mmu-mir-466b-3, mmu-mir-466c-1, mmu-mir-466e, mmu-mir-466f-1, mmu-mir-466f-2, mmu-mir-466f-3, mmu-mir-466g, mmu-mir-466h, mmu-mir-467c, mmu-mir-467d, mmu-mir-92b, mmu-mir-466d, hsa-mir-297, mmu-mir-467e, mmu-mir-466l, mmu-mir-669g, mmu-mir-466i, mmu-mir-466f-4, mmu-mir-466k, mmu-mir-467f, mmu-mir-466j, mmu-mir-467g, mmu-mir-467h, mmu-mir-1195, hsa-mir-548j, hsa-mir-1285-1, hsa-mir-1285-2, hsa-mir-1289-1, hsa-mir-1289-2, hsa-mir-548k, hsa-mir-1299, hsa-mir-548l, hsa-mir-1302-1, hsa-mir-1302-2, hsa-mir-1302-3, hsa-mir-1302-4, hsa-mir-1302-5, hsa-mir-1302-6, hsa-mir-1302-7, hsa-mir-1302-8, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-1255a, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-1268a, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-1255b-1, hsa-mir-1255b-2, mmu-mir-1906-1, hsa-mir-1972-1, hsa-mir-548q, mmu-mir-466m, mmu-mir-466o, mmu-mir-467a-2, mmu-mir-467a-3, mmu-mir-466c-2, mmu-mir-467a-4, mmu-mir-466b-4, mmu-mir-467a-5, mmu-mir-466b-5, mmu-mir-467a-6, mmu-mir-466b-6, mmu-mir-467a-7, mmu-mir-466b-7, mmu-mir-467a-8, mmu-mir-467a-9, mmu-mir-467a-10, mmu-mir-466p, mmu-mir-466n, mmu-mir-466b-8, hsa-mir-3116-1, hsa-mir-3116-2, hsa-mir-3118-1, hsa-mir-3118-2, hsa-mir-3118-3, hsa-mir-548s, hsa-mir-378b, hsa-mir-466, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-3156-1, hsa-mir-3118-4, hsa-mir-3174, hsa-mir-3179-1, hsa-mir-3179-2, hsa-mir-3179-3, hsa-mir-548w, hsa-mir-3156-2, hsa-mir-3156-3, hsa-mir-548x, mmu-mir-3470a, mmu-mir-3470b, mmu-mir-3471-1, mmu-mir-3471-2, hsa-mir-378c, hsa-mir-1972-2, hsa-mir-1302-9, hsa-mir-1302-10, hsa-mir-1302-11, mmu-mir-1906-2, hsa-mir-3683, hsa-mir-3690-1, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-1268b, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-378f, hsa-mir-378g, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-378h, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-378i, hsa-mir-548am, hsa-mir-548an, mmu-mir-28c, mmu-mir-378b, mmu-mir-28b, hsa-mir-548ao, hsa-mir-548ap, mmu-mir-466q, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-378j, mmu-mir-378c, mmu-mir-378d, hsa-mir-548ay, hsa-mir-548az, hsa-mir-3690-2, mmu-mir-290b, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-3179-4, mmu-mir-466c-3, hsa-mir-548bc, mmu-mir-1271
For example, the mir-548 family (derived from MADE1 element) is primate-specific [16] and the mir-1302 family (derived from MER53 element) is a placental-specific miRNA family [20]. [score:1]
It is remarkable that the 42 human miRNA genes and the 25 rhesus miRNA genes that share sequences with MADE1 elements are all members of the miRNA-548 family (Table S1). [score:1]
Examples of this are the mir-297, mir-466, mir-467, mir-548 [16], mir-1302 [20], mir-1972, mir-3118 and mir-3179 families (which are all RrmiR families listed here) (Table S5). [score:1]
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[+] score: 2
Most of these 34 aligned to 1–4 distinct miRNAs, but 6 aligned to a large number (18–69) of sequences within the miRNA gene family hsa-miR-548. [score:1]
Five of the six sequences that aligned to the hsa-miR-548 family also aligned to each other. [score:1]
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[+] score: 2
GAIT is a specific binding site of hsa-miR-548, a miRNA known to be involved in the regulation of actin cytoskeleton, MAPK signaling pathway, ubiquitin mediated proteolysis and of several types of cancer [54]. [score:2]
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[+] score: 2
For example, six copies of hsa-mir-3118 in human genome are all partly derived from LINE/L1PA13 and a large miRNA group, hsa-mir-548, is derived from DNA/MADE1 element. [score:1]
For instance, mir-28, mir-95 and mir-151 are derived from LINE-2 TEs, and mir-548 family is derived from Made1 TEs [21– 23]. [score:1]
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[+] score: 2
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-93, mmu-let-7g, mmu-let-7i, mmu-mir-126a, mmu-mir-302a, mmu-let-7d, hsa-let-7g, hsa-let-7i, hsa-mir-126, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-93, hsa-mir-302a, mmu-mir-466a, hsa-mir-551b, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-626, hsa-mir-548d-1, hsa-mir-548d-2, mmu-mir-551b, mmu-mir-763, mmu-mir-680-2, mmu-mir-692-1, mmu-mir-327, mmu-mir-466b-1, mmu-mir-466b-2, mmu-mir-466b-3, mmu-mir-466c-1, mmu-mir-466e, mmu-mir-466f-1, mmu-mir-466f-2, mmu-mir-466f-3, mmu-mir-466g, mmu-mir-466h, mmu-mir-466d, mmu-mir-466l, mmu-mir-466i, mmu-mir-466f-4, mmu-mir-466k, mmu-mir-466j, mmu-mir-467g, hsa-mir-1233-1, hsa-mir-1234, hsa-mir-548j, hsa-mir-548k, hsa-mir-1299, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-1255a, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-1268a, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-103b-2, hsa-mir-320d-2, hsa-mir-548q, mmu-mir-466m, mmu-mir-466o, mmu-mir-466c-2, mmu-mir-466b-4, mmu-mir-466b-5, mmu-mir-466b-6, mmu-mir-466b-7, mmu-mir-466p, mmu-mir-466n, mmu-mir-466b-8, hsa-mir-548s, hsa-mir-466, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-3176, hsa-mir-548w, hsa-mir-548x, mmu-mir-3471-1, hsa-mir-4281, hsa-mir-1302-11, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-1268b, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-3689c, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, mmu-mir-466q, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, mmu-let-7j, hsa-mir-548ay, hsa-mir-548az, mmu-let-7k, mmu-mir-126b, hsa-mir-548ba, hsa-mir-548bb, mmu-mir-466c-3, hsa-mir-548bc
The same situation is found for all 58 members of the HSA-MIR-548 family. [score:1]
Jordan et al. showed that six human pre-miRNAs (HSA-MIR-548) correspond to TEs [20]. [score:1]
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[+] score: 2
Through an analysis of intensity distributions and q-value estimates [24], we find all of the 4 miRNAs (hsa-miR-548-3p, hsa-miR-1323, hsa-miR-940 and hsa-miR-1292) to be significantly up regulated in females with a 1.63 to 1.94 fold-change in intensity levels (Fig. S4). [score:2]
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[+] score: 2
belong to the same miR-548 family [17] and have been implicated in tumorigenesis [18, 19], however their regulatory functions in gynecological cancers remain largely unknown. [score:2]
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[+] score: 2
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-16-1, hsa-mir-21, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-32, hsa-mir-33a, hsa-mir-96, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-16-2, hsa-mir-192, hsa-mir-199a-1, hsa-mir-148a, hsa-mir-30c-2, hsa-mir-10a, hsa-mir-10b, hsa-mir-34a, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-182, hsa-mir-183, hsa-mir-199a-2, hsa-mir-199b, hsa-mir-203a, hsa-mir-204, hsa-mir-211, hsa-mir-212, hsa-mir-181a-1, hsa-mir-214, hsa-mir-217, hsa-let-7g, hsa-let-7i, hsa-mir-15b, hsa-mir-27b, hsa-mir-122, hsa-mir-125b-1, hsa-mir-132, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-137, hsa-mir-138-2, hsa-mir-145, hsa-mir-152, hsa-mir-153-1, hsa-mir-153-2, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125b-2, hsa-mir-126, hsa-mir-127, hsa-mir-136, hsa-mir-138-1, hsa-mir-146a, hsa-mir-150, hsa-mir-185, hsa-mir-193a, hsa-mir-194-1, hsa-mir-320a, hsa-mir-155, hsa-mir-181b-2, hsa-mir-194-2, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-200a, hsa-mir-34c, hsa-mir-26a-2, hsa-mir-302b, hsa-mir-369, hsa-mir-375, hsa-mir-378a, hsa-mir-328, hsa-mir-335, hsa-mir-133b, hsa-mir-409, hsa-mir-484, hsa-mir-485, hsa-mir-486-1, hsa-mir-490, hsa-mir-495, hsa-mir-193b, hsa-mir-497, hsa-mir-512-1, hsa-mir-512-2, hsa-mir-506, hsa-mir-509-1, hsa-mir-532, hsa-mir-92b, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-33b, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-1224, hsa-mir-320b-1, hsa-mir-320c-1, hsa-mir-320b-2, hsa-mir-378d-2, hsa-mir-802, hsa-mir-509-2, hsa-mir-509-3, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-320d-1, hsa-mir-320c-2, hsa-mir-320d-2, hsa-mir-548q, hsa-mir-548s, hsa-mir-378b, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-320e, hsa-mir-548x, hsa-mir-378c, hsa-mir-4262, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-378f, hsa-mir-378g, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-378h, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-378i, hsa-mir-548am, hsa-mir-548an, hsa-mir-203b, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-378j, hsa-mir-548ay, hsa-mir-548az, hsa-mir-486-2, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc
Patients with alcoholic cardiomyopathy showed changes in several microRNAs (miR-138, miR-485-5p, miR-506, miR-512-5p, miR-548-3p, and miR-4262) and suggested to be involved in the development of cardiac dysfunction [171]. [score:2]
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31
[+] score: 2
Other miRNAs from this paper: hsa-mir-29a, hsa-mir-101-1, hsa-mir-139, hsa-mir-218-1, hsa-mir-218-2, hsa-mir-142, hsa-mir-144, hsa-mir-127, hsa-mir-154, hsa-mir-185, hsa-mir-195, hsa-mir-29c, hsa-mir-101-2, hsa-mir-380, hsa-mir-381, hsa-mir-323a, hsa-mir-520e, hsa-mir-520a, hsa-mir-518c, hsa-mir-520d, hsa-mir-518a-1, hsa-mir-518d, hsa-mir-518a-2, hsa-mir-519a-1, hsa-mir-519a-2, hsa-mir-513a-1, hsa-mir-513a-2, hsa-mir-509-1, hsa-mir-576, hsa-mir-548a-1, hsa-mir-586, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-599, hsa-mir-548a-3, hsa-mir-607, hsa-mir-613, hsa-mir-548c, hsa-mir-625, hsa-mir-634, hsa-mir-642a, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-656, hsa-mir-509-2, hsa-mir-509-3, hsa-mir-1208, hsa-mir-548j, hsa-mir-1290, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-1247, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-1324, hsa-mir-1825, hsa-mir-548q, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-323b, hsa-mir-548w, hsa-mir-548x, hsa-mir-548y, hsa-mir-642b, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-548ay, hsa-mir-548az, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc
Moreover, although the miR-548 miRNA family has been identified in Homo sapiens, Pan troglodytes, Pongo pygmaeus and Macaca mulatta, the miR-548d members present the particularity of being present only in Homo sapiens and Macaca mulatta. [score:1]
Indeed, the numbers of miRNAs of the miR-548 and C19MC families increase from Macaca mulatta and Pongo pygmaeus, to Pan troglodytes and Homo sapiens, via homolog or partially homolog replication (transposable elements) [29], [38]. [score:1]
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[+] score: 2
Other miRNAs from this paper: hsa-mir-200b, hsa-mir-301a, hsa-mir-515-1, hsa-mir-515-2, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, mml-mir-301a, mml-mir-548a, mml-mir-548b, mml-mir-548c, mml-mir-548d, mml-mir-548e, mml-mir-548f, ptr-mir-301a, ptr-mir-515-1, ptr-mir-515-2, ptr-mir-548a-1, ptr-mir-548a-2, ptr-mir-548b, ptr-mir-548c, ptr-mir-548f-1, ptr-mir-548f-2, ptr-mir-548h, ptr-mir-548i-1, ptr-mir-548i-2, ptr-mir-548i-3, ptr-mir-548i-4, ptr-mir-548i-5, ptr-mir-548j, ptr-mir-548k, ptr-mir-548l, ptr-mir-548n, ptr-mir-548p, hsa-mir-2115, hsa-mir-548q, hsa-mir-2681, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-3065, hsa-mir-548x, ppy-mir-515-1, ppy-mir-515-2, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-4511, hsa-mir-548am, hsa-mir-548an, hsa-mir-4691, hsa-mir-203b, hsa-mir-4760, hsa-mir-4762, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, ptr-mir-548o, ptr-mir-548e, ggo-mir-548b, ggo-mir-203b, ggo-mir-548c, ggo-mir-548e, ggo-mir-548a, ggo-mir-548d, ggo-mir-548f, ggo-mir-200b, ppy-mir-548e, ppy-mir-548a, ppy-mir-548h, ppy-mir-548f, ppy-mir-548c, hsa-mir-548ay, hsa-mir-548az, mml-mir-548g, mml-mir-548h, mml-mir-548i, mml-mir-548j, hsa-mir-548ba, hsa-mir-548bb, ggo-mir-515-1, ggo-mir-515-2, ppy-mir-515-3, hsa-mir-548bc, ggo-mir-301a, ppy-mir-301a
The Infernal tool lacks sufficient power to classify miR-548 family; only 12 members of the miR-548 family have been identified in humans, and none of the 31 miR-548 precursors have been identified in marmoset, although they are homologs of human pre-miRNAs. [score:1]
In the human genome, the largest miRNA family in the current miRBase is the miR-548 family with 69 pre-miRNA members; the second largest is the miR-515 family with 42 members. [score:1]
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[+] score: 2
A total of twelve miRNAs were found to be commonly regulated over time in these three tissues; let-7d, let-7e, miR-1249, miR-1254, miR-1255, miR-1273, miR-1285, miR-1301, miR-1306, miR-548, and miR-8078. [score:2]
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[+] score: 1
MiRNAs miR-1272, miR-548, miR-208a, miR-1298, miR-708 and miR140-3p were predicted to bind to the CD38 3’UTR with high context score. [score:1]
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[+] score: 1
Interestingly, we identified seven miRNAs miR-98-3p, miR-140–3p, miR-191-3p, miR-342-5p, miR-548e-5p and miR-2116–3p – that showed a change in the 5’ start site of the dominant sequence upon infection with one or more bacteria (Fig. 4F). [score:1]
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36
[+] score: 1
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-mir-17, hsa-mir-18a, hsa-mir-19a, hsa-mir-20a, hsa-mir-21, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-93, hsa-mir-101-1, hsa-mir-106a, hsa-mir-107, hsa-mir-192, hsa-mir-34a, hsa-mir-204, hsa-mir-205, hsa-mir-214, hsa-mir-215, hsa-mir-222, hsa-mir-223, hsa-mir-1-2, hsa-mir-15b, hsa-mir-125b-1, hsa-mir-141, hsa-mir-191, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-126, hsa-mir-127, hsa-mir-149, hsa-mir-184, hsa-mir-186, hsa-mir-200c, hsa-mir-1-1, hsa-mir-200a, hsa-mir-101-2, hsa-mir-34b, hsa-mir-34c, hsa-mir-339, hsa-mir-146b, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-624, hsa-mir-650, hsa-mir-651, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-449b, hsa-mir-1185-2, hsa-mir-1283-1, hsa-mir-1185-1, hsa-mir-708, hsa-mir-548j, hsa-mir-1285-1, hsa-mir-1285-2, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-1283-2, hsa-mir-548q, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-548ay, hsa-mir-548az, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc
Furthermore, the miR-17 and miR-548 families were the most enriched ones with five and seven members involved, respectively. [score:1]
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[+] score: 1
Several miRNA genes show high similarity (such as 68 mir-548 paralogous miRNAs in humans). [score:1]
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[+] score: 1
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-30a, hsa-mir-32, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-196a-1, hsa-mir-30d, hsa-mir-196a-2, hsa-let-7g, hsa-let-7i, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-149, hsa-mir-200c, hsa-mir-425, hsa-mir-505, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-625, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-664a, hsa-mir-103b-1, hsa-mir-103b-2, hsa-mir-548q, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-3146, hsa-mir-548v, hsa-mir-3174, hsa-mir-548w, hsa-mir-3192, hsa-mir-548x, hsa-mir-3605, hsa-mir-3662, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-664b, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-548ay, hsa-mir-548az, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc
For instance, many members of miR-548 family and siRNAs are derived from inverted-repeats of the MADE1 retrotransposon [23]. [score:1]
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[+] score: 1
Interestingly, community A harbors all the interactions involving the miR-548 family, which is one of largest miRNA families in human genome and some of its members may form miRNA-miRNA duplexes [95]. [score:1]
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[+] score: 1
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-17, hsa-mir-20a, hsa-mir-21, hsa-mir-22, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-27a, hsa-mir-30a, hsa-mir-93, hsa-mir-96, hsa-mir-99a, hsa-mir-100, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-105-1, hsa-mir-105-2, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-10a, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-182, hsa-mir-205, hsa-mir-212, hsa-mir-181a-1, hsa-mir-222, hsa-mir-224, hsa-let-7g, hsa-let-7i, hsa-mir-23b, hsa-mir-27b, hsa-mir-30b, hsa-mir-122, hsa-mir-125b-1, hsa-mir-132, hsa-mir-141, hsa-mir-145, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-146a, hsa-mir-150, hsa-mir-184, hsa-mir-188, hsa-mir-320a, hsa-mir-181b-2, hsa-mir-30c-1, hsa-mir-302a, hsa-mir-34c, hsa-mir-30e, hsa-mir-302b, hsa-mir-302c, hsa-mir-302d, hsa-mir-371a, hsa-mir-372, hsa-mir-376a-1, hsa-mir-378a, hsa-mir-383, hsa-mir-339, hsa-mir-133b, hsa-mir-345, hsa-mir-425, hsa-mir-483, hsa-mir-146b, hsa-mir-202, hsa-mir-193b, hsa-mir-181d, hsa-mir-498, hsa-mir-518f, hsa-mir-518b, hsa-mir-520c, hsa-mir-518c, hsa-mir-518e, hsa-mir-518a-1, hsa-mir-518d, hsa-mir-518a-2, hsa-mir-503, hsa-mir-513a-1, hsa-mir-513a-2, hsa-mir-376a-2, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-645, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-320b-1, hsa-mir-320c-1, hsa-mir-320b-2, hsa-mir-378d-2, hsa-mir-744, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-302e, hsa-mir-302f, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-320d-1, hsa-mir-320c-2, hsa-mir-320d-2, hsa-mir-548q, hsa-mir-548s, hsa-mir-378b, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-320e, hsa-mir-548x, hsa-mir-378c, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-378f, hsa-mir-378g, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-378h, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-378i, hsa-mir-548am, hsa-mir-548an, hsa-mir-371b, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-378j, hsa-mir-548ay, hsa-mir-548az, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc
They are enriched in chromosomes 19 and X and represented by the miR-548 family. [score:1]
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[+] score: 1
Notwithstanding sparse published functional evidences the miR-548 family is represented by altogether 252 CpG sites. [score:1]
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[+] score: 1
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-30a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-100, hsa-mir-101-1, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-34a, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-30b, hsa-mir-144, hsa-mir-153-1, hsa-mir-153-2, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-1-1, hsa-mir-30c-1, hsa-mir-200a, hsa-mir-101-2, hsa-mir-34b, hsa-mir-34c, hsa-mir-30e, hsa-mir-92b, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-769, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-548q, bma-let-7, bma-lin-4, bma-mir-2a, bma-mir-2b-1, bma-mir-2b-2, bma-mir-2c, bma-mir-9, bma-mir-34, bma-mir-71, bma-mir-72, bma-mir-92, bma-mir-100a, bma-mir-100b, bma-mir-100c, bma-mir-100d, bma-mir-153, bma-mir-228, bma-mir-279, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-548ay, hsa-mir-548az, bma-mir-2i, bma-mir-2g, bma-mir-2e, hsa-mir-548ba, bma-mir-252, bma-mir-2d, bma-mir-84-1, bma-mir-84-2, bma-mir-2f, bma-mir-2h-1, bma-mir-2h-2, hsa-mir-548bb, hsa-mir-548bc
The largest miRNA family identified was let-7 consisting of 13 members, followed by miR-30, miR-2, miR-9, miR-92 and miR-548, which processed 10, 9, 8, 8 and 8 members, respectively. [score:1]
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[+] score: 1
Other substantially enriched structural ncRNAs included SCARNA7, tRNA, and miR-548, which are all reported to be functional ncRNAs in human lymphoid cells 51– 53. [score:1]
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[+] score: 1
Therefore, we firstly choose BMP9 representing the tempting way and miR-548-5p representing the blocking way to explore possible synergetic effects on MSCs osteogenic differentiation. [score:1]
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[+] score: 1
An example of this is the hsa-mir-548 family, the members of which are derived from Made1 transposable elements [19]. [score:1]
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