sort by

4 publications mentioning ptr-let-7i

Open access articles that are associated with the species Pan troglodytes and mention the gene name let-7i. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 18
The most downregulated miRNA during EB formation was miR-let-7a, which is of interest because let-7 has been shown to regulate developmental timing in Caenorhabditis elegans [22]. [score:6]
RISC -mediated target RNA cleavage activity was determined by in vitro cleavage of a [32]P-target mRNA that perfectly matched the miR-302b or let-7 sequence. [score:5]
Fig 4A demonstrates the specific expression of miR-302b and let-7 in hES and HeLa cells, respectively. [score:3]
Conversely, let-7 RISC in HeLa extracts cleaved let-7 target RNA while hES RISC did not show detectable activity in this experiment. [score:3]
Since let-7a is abundant in HeLa, we selected let-7 as a control in our experiments. [score:1]
[1 to 20 of 5 sentences]
[+] score: 3
rs17123507 was the only one located in the exon region (3′UTR) of FLJ33706 among a tandem set of putative binding sites of let-7, a brain-expressed miRNA implicated in neuron specification [31]. [score:3]
[1 to 20 of 1 sentences]
[+] score: 2
This oligomer effectively prevented let-7 action in vitro, in cultured HeLa cells following transfection using a liposomal reagent, and in C. elegans after injection. [score:1]
The first application of this approach used an RNA oligomer complementary to the miRNA let-7, with 2′-O-methyl (2′-OMe) modifications at each position [21]. [score:1]
[1 to 20 of 2 sentences]
[+] score: 1
The comparisons among fish (Figure 5B) revealed that conservation between pufferfishes and zebrafish sequences was largely limited to coding regions and to a microRNA (family let-7) positioned upstream of the HADH2 gene, reflecting the deep divergence of the Euteleostei (110–160 million years; Myr) [29]. [score:1]
[1 to 20 of 1 sentences]