miRNA Search Results

sort by 1 publications mentioning ptr-mir-383 Open access articles that are associated with the species Pan troglodytes and mention the gene name mir-383. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.
1	[+] score: 17 Other miRNAs from this paper: hsa-mir-143, hsa-mir-154, hsa-mir-184, hsa-mir-34c, hsa-mir-299, hsa-mir-375, hsa-mir-383, hsa-mir-487a, ptr-mir-143, ptr-mir-154, ptr-mir-184, hsa-mir-499a, mml-mir-34c, mml-mir-143, mml-mir-154, mml-mir-184, mml-mir-299, mml-mir-375, mml-mir-383, mml-mir-487a, mml-mir-499, ptr-mir-34c, ptr-mir-375, ptr-mir-487a, ptr-mir-499, ptr-mir-299, hsa-mir-499b To assess whether miRNA with expression divergence on the human lineage might be associated with human cognitive functions, we investigated the expression of genes targeted by five miRNA showing human-specific expression, according to multiple methodologies: miR-184, miR-487a, miR-383, miR-34c-5p and miR-299-3p (Figure 2). [score:7] This effect was significant for combined targets of the five miRNA, as well as for targets of miR-184 and miR-383 analyzed individually. [score:5] Requiring significant support by at least two out of three methodologies (sequencing, microarrays and Q-PCR), expression changes in five miRNA (miR-184, miR-299-3p, miR-487a, miR-383 and miR-34c-5p) could be assigned to the human evolutionary lineage and two (miR-375 and miR-154*) to the chimpanzee evolutionary lineage (Figure 2). [score:3] We chose three types of miRNA differences: (1) consistent by both methodologies: miR-383 and miR-34c-5p; (2) significant according to sequencing, but unconfirmed in the microarray experiment: miR-143 and miR-499; (3) significant according to sequencing, but not detected or masked on the microarrays: miR-184 and miR-299-3p. [score:1] On the DNA sequence level, these miRNA tend to be conserved: miR-184 mature miRNA sequence is evolutionarily conserved from insects to humans, with only one nucleotide different at 3′end of mature sequence, while miR-383 and miR-34c-5p are classified as broadly conserved and miR-299-3p - as conserved among animal species [25], [31]. [score:1] [1 to 20 of 5 sentences]

To assess whether miRNA with expression divergence on the human lineage might be associated with human cognitive functions, we investigated the expression of genes targeted by five miRNA showing human-specific expression, according to multiple methodologies: miR-184, miR-487a, miR-383, miR-34c-5p and miR-299-3p (Figure 2). [score:7]

This effect was significant for combined targets of the five miRNA, as well as for targets of miR-184 and miR-383 analyzed individually. [score:5]

Requiring significant support by at least two out of three methodologies (sequencing, microarrays and Q-PCR), expression changes in five miRNA (miR-184, miR-299-3p, miR-487a, miR-383 and miR-34c-5p) could be assigned to the human evolutionary lineage and two (miR-375 and miR-154*) to the chimpanzee evolutionary lineage (Figure 2). [score:3]

We chose three types of miRNA differences: (1) consistent by both methodologies: miR-383 and miR-34c-5p; (2) significant according to sequencing, but unconfirmed in the microarray experiment: miR-143 and miR-499; (3) significant according to sequencing, but not detected or masked on the microarrays: miR-184 and miR-299-3p. [score:1]

On the DNA sequence level, these miRNA tend to be conserved: miR-184 mature miRNA sequence is evolutionarily conserved from insects to humans, with only one nucleotide different at 3′end of mature sequence, while miR-383 and miR-34c-5p are classified as broadly conserved and miR-299-3p - as conserved among animal species [25], [31]. [score:1]

[1 to 20 of 5 sentences]

miRBase

1 publications mentioning ptr-mir-383