1 |
[+]
score:
30
Other miRNAs from this paper: hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-20a, hsa-mir-21, hsa-mir-30a, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-148a, hsa-mir-30d, hsa-mir-221, hsa-mir-222, hsa-mir-223, hsa-let-7g, hsa-mir-1-2, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-144, hsa-mir-126, hsa-mir-146a, hsa-mir-150, hsa-mir-206, hsa-mir-320a, hsa-mir-1-1, hsa-mir-155, hsa-mir-361, hsa-mir-148b, hsa-mir-133b, hsa-mir-425, hsa-mir-451a, hsa-mir-486-1, hsa-mir-489, hsa-mir-499a, hsa-mir-1224, bta-mir-103-1, bta-mir-148a, bta-mir-20a, bta-mir-21, bta-mir-221, bta-mir-222, bta-mir-30d, bta-mir-320a-2, bta-mir-499, bta-mir-126, bta-mir-148b, bta-mir-29b-2, bta-mir-361, bta-mir-425, bta-let-7g, bta-mir-30a, bta-mir-150, bta-mir-103-2, bta-mir-19b, hsa-mir-208b, hsa-mir-1246, hsa-mir-1249, hsa-mir-103b-1, hsa-mir-103b-2, bta-mir-1-2, bta-mir-1-1, bta-mir-133a-2, bta-mir-133a-1, bta-mir-133b, bta-mir-144, bta-mir-146a, bta-mir-155, bta-mir-206, bta-mir-223, bta-mir-451, bta-mir-486, bta-mir-489, bta-mir-1224, bta-mir-29b-1, bta-mir-1249, bta-mir-2305, bta-mir-1584, bta-mir-2413, bta-mir-1777a, bta-mir-1777b, bta-mir-2478, bta-mir-320a-1, bta-mir-2888-1, bta-mir-2888-2, hsa-mir-1260b, hsa-mir-4286, bta-mir-148c, hsa-mir-451b, hsa-mir-499b, bta-mir-1246, bta-mir-1260b, bta-mir-4286-1, bta-mir-4286-2, hsa-mir-486-2, bta-mir-148d
In the present study, miR-451 expression in the BP muscle of the grazing cattle was temporarily up-regulated at 2 mo compared to the housed cattle, which suggests the positive effect of grazing on miR-451 expression in skeletal muscles, as well as on miR-206 and miR-208b [16].
[score:7]
Although miR-206 and miR-208b expression in the BP muscle of cattle was up-regulated by grazing [16], the unchanged muscle-specific miRNA levels in circulation in our study suggest that grazing is a mild form of exercise or movement for cattle that does not induce muscle damage.
[score:6]
We recently reported that miR-206 and miR-208b expressions in the biceps femoris (BP) muscle of grazing Japanese Shorthorn cattle were elevated after 4 months of grazing; these miRNAs are associated with temporary down-regulation of MyoD and fast-type myosin heavy chain isoform [16], which could be associated with conversion of the bovine skeletal muscle type with miRNA profile [17].
[score:6]
Although the effect of nutrition or movement during grazing could not be separately evaluated, the grazing of cattle in our previous study [16] resulted in significant up-regulation of miR-208b and down-regulation of miR-206, MyoD and MyHC-2x, which indicated that the skeletal muscle of the grazing cattle physiologically adapted to the increased movement.
[score:5]
Recent studies of muscle-specific miRNAs such as miR-1, miR-133a/b, miR-206, and miR-208b have indicated their roles in the development or specification of skeletal muscle [5– 7].
[score:2]
Muscle-specific miRNAs such as miR-1, miR-133a, miR-206, miR-208b, and miR-499 were not significantly detected in the plasma exosomes across all samples (i. e., grazing and housed during experiment) except for miR-486 (0.18%) and a trace of miR-133b (< 0.001%).
[score:1]
Moreover, circulation levels of miR-1, miR-133a/b, and/or miR-208b significantly increased during early recovery of muscle-damaging downhill walking in healthy subjects [31] and in the 3-h period following a non-muscle-damaging single bout of cycling [32], suggesting that the profile of c-miRNAs are affected by the mode and intensity of the exercise.
[score:1]
In the present study, among the 231 exosomal miRNAs detected in the cattle plasma, muscle-enriched miR-486 and a trace of miR133b were detected, but miR-1, miR-133a, miR-206, miR-208b, and miR-499 were not detected.
[score:1]
Indeed, muscle-specific miR-1, miR-133a/b, miR-206, and/or miR-208b in circulation have been shown to be changed by muscle-damaging downhill walking [31] and marathon running in humans [39, 57].
[score:1]
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2 |
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score:
17
Other miRNAs from this paper: bta-mir-26a-2, bta-mir-29a, bta-mir-103-1, bta-mir-20a, bta-mir-21, bta-mir-30d, bta-mir-499, bta-mir-125b-1, bta-mir-27b, bta-mir-30b, bta-mir-106a, bta-mir-107, bta-mir-140, bta-mir-142, bta-mir-15b, bta-mir-345, bta-mir-92a-2, bta-mir-98, bta-mir-17, bta-mir-210, bta-mir-29b-2, bta-mir-425, bta-let-7g, bta-mir-10b, bta-mir-150, bta-mir-23b, bta-mir-103-2, bta-mir-125b-2, bta-mir-15a, bta-mir-19a, bta-mir-19b, bta-mir-1-2, bta-mir-1-1, bta-mir-130b, bta-mir-133a-2, bta-mir-133a-1, bta-mir-196a-2, bta-mir-196a-1, bta-mir-197, bta-mir-206, bta-mir-208a, bta-mir-26a-1, bta-mir-28, bta-mir-301a, bta-mir-374b, bta-mir-451, bta-mir-486, bta-mir-496, bta-mir-874, bta-mir-885, bta-mir-92a-1, bta-mir-29b-1, bta-mir-2295, bta-mir-2305, bta-mir-2368, bta-mir-1584, bta-mir-2412, bta-mir-2425, bta-mir-2478, bta-mir-2284x, bta-mir-1260b, bta-mir-652
In addition, skeletal muscle miR-206 and miR-208b expression is temporally upregulated, accompanying the downregulation of myosin heavy chain 2x expression, in grazing Japanese Shorthorn (JSH) cattle whereas the expression did not change in housed [7].
[score:13]
It was expected that grazing would shift the muscle properties toward slow-oxidative type and decreased adipogenicity, which is associated with expression of miR-206 [29, 30], miR-208b [31], and adipogenic genes such as PPARG2 [20, 21, 25].
[score:3]
We also conducted qPCR of miRNAs that are enriched in muscle or plasma (miR-21-5p, miR-30d-5p, miR-103, miR-206, miR-208b, miR-451, miR-486, miR-499, miR-2412, and miR-2478), some of which are abundant in bovine skeletal muscles [4].
[score:1]
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score:
2
Other miRNAs from this paper: hsa-mir-17, hsa-mir-19a, hsa-mir-29a, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-198, hsa-mir-208a, hsa-mir-10a, hsa-mir-223, hsa-mir-122, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-125b-1, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125b-2, hsa-mir-126, hsa-mir-146a, hsa-mir-150, hsa-mir-155, hsa-mir-29c, hsa-mir-99b, hsa-mir-296, hsa-mir-196b, hsa-mir-515-1, hsa-mir-515-2, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-550a-1, hsa-mir-550a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-640, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-550a-3, bta-mir-29a, bta-mir-125b-1, bta-mir-126, bta-mir-10a, bta-mir-124a-1, bta-mir-17, bta-mir-29b-2, bta-mir-29c, bta-mir-150, bta-mir-122, bta-mir-125b-2, bta-mir-19a, bta-mir-99b, hsa-mir-208b, hsa-mir-548e, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, bta-mir-124a-2, bta-mir-124b, bta-mir-146a, bta-mir-155, bta-mir-196b, bta-mir-208a, bta-mir-223, bta-mir-296, bta-mir-29d, bta-mir-9-1, bta-mir-9-2, bta-mir-29e, bta-mir-29b-1, hsa-mir-548q, bta-mir-2284i, bta-mir-2285a, bta-mir-2284s, bta-mir-2285d, bta-mir-2284l, bta-mir-2284j, bta-mir-2284t, bta-mir-2285b-1, bta-mir-2284d, bta-mir-2284n, bta-mir-2284g, bta-mir-2284p, bta-mir-2284u, bta-mir-2284f, bta-mir-2284a, bta-mir-2284k, bta-mir-2284c, bta-mir-2284v, bta-mir-2285c, bta-mir-2284q, bta-mir-2284m, bta-mir-2284b, bta-mir-2284r, bta-mir-2284h, bta-mir-2284o, bta-mir-2284e, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, bta-mir-2284w, bta-mir-2284x, hsa-mir-548y, hsa-mir-550b-1, hsa-mir-550b-2, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, bta-mir-2284y-1, bta-mir-2285e-1, bta-mir-2285e-2, bta-mir-2285f-1, bta-mir-2285f-2, bta-mir-2285g-1, bta-mir-2285h, bta-mir-2285i, bta-mir-2285j-1, bta-mir-2285j-2, bta-mir-2285k-1, bta-mir-2285l, hsa-mir-548ay, hsa-mir-548az, bta-mir-2285o-1, bta-mir-2285o-2, bta-mir-2285n-1, bta-mir-2285n-2, bta-mir-2285p, bta-mir-2285m-1, bta-mir-2285m-2, bta-mir-2284y-2, bta-mir-2285n-3, bta-mir-2285n-4, bta-mir-2284y-3, bta-mir-2285o-3, bta-mir-2285o-4, bta-mir-2285m-3, bta-mir-2284y-4, bta-mir-2284y-5, bta-mir-2284y-6, bta-mir-2285m-4, bta-mir-2285o-5, bta-mir-2285m-5, bta-mir-2285n-5, bta-mir-2285n-6, bta-mir-2284y-7, bta-mir-2285n-7, bta-mir-2284z-1, bta-mir-2284aa-1, bta-mir-2285k-2, bta-mir-2284z-3, bta-mir-2284aa-2, bta-mir-2284aa-3, bta-mir-2285k-3, bta-mir-2285k-4, bta-mir-2284z-4, bta-mir-2285k-5, bta-mir-2284z-5, bta-mir-2284z-6, bta-mir-2284z-7, bta-mir-2284aa-4, bta-mir-2285q, bta-mir-2285r, bta-mir-2285s, bta-mir-2285t, bta-mir-2285b-2, bta-mir-2285v, bta-mir-2284z-2, bta-mir-2285g-2, bta-mir-2285g-3, bta-mir-2285af-1, bta-mir-2285af-2, bta-mir-2285y, bta-mir-2285w, bta-mir-2285x, bta-mir-2285z, bta-mir-2285u, bta-mir-2285aa, bta-mir-2285ab, bta-mir-2284ab, bta-mir-2285ac, bta-mir-2285ad, bta-mir-2284ac, bta-mir-2285ae, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc, bta-mir-2285ag, bta-mir-2285ah, bta-mir-2285ai, bta-mir-2285aj, bta-mir-2285ak, bta-mir-2285al, bta-mir-2285am, bta-mir-2285ar, bta-mir-2285as-1, bta-mir-2285as-2, bta-mir-2285as-3, bta-mir-2285at-1, bta-mir-2285at-2, bta-mir-2285at-3, bta-mir-2285at-4, bta-mir-2285au, bta-mir-2285av, bta-mir-2285aw, bta-mir-2285ax-1, bta-mir-2285ax-2, bta-mir-2285ax-3, bta-mir-2285ay, bta-mir-2285az, bta-mir-2285an, bta-mir-2285ao-1, bta-mir-2285ao-2, bta-mir-2285ap, bta-mir-2285ao-3, bta-mir-2285aq-1, bta-mir-2285aq-2, bta-mir-2285ba-1, bta-mir-2285ba-2, bta-mir-2285bb, bta-mir-2285bc, bta-mir-2285bd, bta-mir-2285be, bta-mir-2285bf-1, bta-mir-2285bf-2, bta-mir-2285bf-3, bta-mir-2285bg, bta-mir-2285bh, bta-mir-2285bi-1, bta-mir-2285bi-2, bta-mir-2285bj-1, bta-mir-2285bj-2, bta-mir-2285bk, bta-mir-2285bl, bta-mir-2285bm, bta-mir-2285bn, bta-mir-2285bo, bta-mir-2285bp, bta-mir-2285bq, bta-mir-2285br, bta-mir-2285bs, bta-mir-2285bt, bta-mir-2285bu-1, bta-mir-2285bu-2, bta-mir-2285bv, bta-mir-2285bw, bta-mir-2285bx, bta-mir-2285by, bta-mir-2285bz, bta-mir-2285ca, bta-mir-2285cb, bta-mir-2285cc, bta-mir-2285cd, bta-mir-2285ce, bta-mir-2285cf, bta-mir-2285cg, bta-mir-2285ch, bta-mir-2285ci, bta-mir-2285cj, bta-mir-2285ck, bta-mir-2285cl, bta-mir-2285cm, bta-mir-2285cn, bta-mir-2285co, bta-mir-2285cp, bta-mir-2285cq, bta-mir-2285cr-1, bta-mir-2285cr-2, bta-mir-2285cs, bta-mir-2285ct, bta-mir-2285cu, bta-mir-2285cv-1, bta-mir-2285cv-2, bta-mir-2285cw-1, bta-mir-2285cw-2, bta-mir-2285cx, bta-mir-2285cy, bta-mir-2285cz, bta-mir-2285da, bta-mir-2285db, bta-mir-2285dc, bta-mir-2285dd, bta-mir-2285de, bta-mir-2285df, bta-mir-2285dg, bta-mir-2285dh, bta-mir-2285di, bta-mir-2285dj, bta-mir-2285dk, bta-mir-2285dl-1, bta-mir-2285dl-2, bta-mir-2285dm
Treatment with anti-miR-208 prevented weight gain in aging mice, which was due to a reduction in fat weight (69).
[score:1]
Similarly, human miR-208 has been shown to have an important role in modulating cardiac function and remo deling (68), and is currently in preclinical trials.
[score:1]
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