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6 publications mentioning bta-mir-874

Open access articles that are associated with the species Bos taurus and mention the gene name mir-874. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 42
Among them, up-regulated bta-miR-196b and down-regulated bta-miR-874 may influence the signal translation of PPAR pathway by their targets involved in the pathway and, consequently, regulate fat deposition. [score:12]
It was illustrated that bta-miR-30f, bta-miR-196b, bta-miR-874 and bta-miR-2887 could regulate the lipid metabolism, glycerophospholipid metabolism, adipocyte differentiation and glucose metabolism via inhibiting the expression of PPAR pathway related genes such as PPARα, RXRα, 3-ketoacyl-CoA thiolase (ACAA1), Apolipoprotein A-5 (APOA5), Peroxisomal acyl-coenzyme A oxidase 2 (ACOX2), Angiopoietin-related protein 4 (ANGPTL4), Apolipoprotein A-1 (APOA1), Integrin-linked protein kinase (ILK), Ubiquitin-60S ribosomal protein L40 (UBA52) and Long-chain fatty acid transport protein 1 (SLC27A1) (Fig. 6). [score:6]
The expression level of 3 differentially expressed miRNAs, bta-miR-320a, bta-miR-874 and bta-miR-1247-3p, and a predicted novel miRNA chr4_8522, were randomly selected and verified by qRT-PCR. [score:5]
Particularly, bta-miR-196b and bta-miR-874 directly regulate the expression of PPARα and RXRα respectively (Fig. 5). [score:5]
Consistent with the data presented in Fig. 5, the results illustrated that PPARα and RXRα played a central role in PPAR signaling pathway, and they might be targets regulated by bta-miR-196b and bta-miR-874, respectively. [score:4]
Moreover, we found that the expression levels of miR-136, miR-190a, miR-411a, miR-708, miR-1940 and miR-2887 were significantly higher in Wagyu compared with Holstein cattle (P < 0.05), while the expression levels of miR-874 and miR-1247–3p were lower (P < 0.05). [score:4]
Particularly, two important transcription factors in PPAR signaling pathway, PPARα and RXRα, were also predicted to be the targets of bta-miR-196b and bta-miR-874, respectively (Fig. 5). [score:3]
Bta-miR-196b, bta-miR-874 and their predicted target genes PPARα, RXRα. [score:3]
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[+] score: 19
Similarly, for those indentified under CS diet, one was rumen specific (miR-2349), and five were tissue DE including three rumen up-regulated (miR-147, -93, and -27b), two liver DE (up-regulated, miR-874; down-regulated, miR-145down-regulated miRNA (miR-145) and one up-regulated miRNA (miR-874) and one mammary gland upregulated (let-7c). [score:19]
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[+] score: 11
The most up-regulated miRNA between GAL and INV stages was miR-874 (p-value = 9.37E-14). [score:4]
MiR-874 potentially targets CLDN10, RAB13 and CLDN18 in tight junctions signalling pathway. [score:2]
Several miRNAs were important (potential) regulators at each lactation stage switch: miR-29b and miR-363 for LAC to GAL switch, and miR-874 and miR-6254 for GAL to INV switch. [score:2]
The corresponding most enriched pathways were axonal guidance signalling (miR-29b), calcium signalling (miR-363), granulocyte adhesion and diapedesis (miR-874), cell cycle: G2/M DNA damage checkpoint regulation (miR-6524), retinol biosynthesis (miR-885) and TGF-β signalling (miR-2285t) (Table S9). [score:2]
The top most significantly DE miRNAs (p-value ≤ 1.00E-12) or with a log2 fold change (|L2FC|) ≥ 3 and p-value ≤ 1.00E-5) between lactation stages are shown in Table 3 while 58 dynamically DE miRNAs are shown in Table 4. The most significantly up and down DE miRNAs between LAC and GAL were miR-29b (p-value = 2.99E-31) and miR-363 (p-value = 2.13E-22), between GAL and INV were miR-874 (p-value = 9.37E-14) and miR-6524 (p-value = 1.84E-09) and between INV and LAC were miR-885 (p-value = 1.70E-31) and miR-2285t (p-value = 7.18E-24), respectively (Tables 3 and S8a–c). [score:1]
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[+] score: 8
Regarding qRT-PCR used validate relative gene expression of the 8 selected miRNAs, we showed in Fig 5E that miR-let-7i, miR-2305 and miR-2890 were upregulated and the expression of miR-874, miR-1, miR-106b, miR-1296 and miR-362-5p decreased in steers. [score:8]
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[+] score: 3
Moreover, Notch 3 and 4 were also targeted by miR-874 and miR-2331-3p in the BLUE module, respectively. [score:3]
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[+] score: 2
Of those miRNAs, the contents of miR-652, miR-30d, miR-301a, miR-345-5p, miR-374b, miR-425-5p, miR-23b-3p, miR-30b-5p, miR-17-5p, miR-98, miR-28, and miR-874 were lower in the plasma of the grazing cattle than in that of the grain-fed cattle, whereas the contents of miR-10b, miR-2368-3p, miR-885, and miR-2425-3p were higher in the plasma of the grazing cattle. [score:1]
The present results of microarray and qPCR revealed that the grazing JB cattle had a higher plasma content of miR-10b and lower plasma contents of miR-17-5p, miR-23b-3p, miR-28, miR-30b-5p, miR-30d, miR-98, miR-301a, miR-345-5p, miR-374b, miR-425-5p, miR-652, and miR-874 than the grain-fed cattle. [score:1]
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