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6 publications mentioning mmu-mir-2137

Open access articles that are associated with the species Mus musculus and mention the gene name mir-2137. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 53
The expressions of miR-711, miR-714, miR-744, miR-2137, miR-5130, miR-1892, miR-328, miR-346, miR-5099, and miR-705 were significantly upregulated in I/R injured heart grafts, while miR-490, miR-491, miR-210, miR-362, miR-24, miR-423, miR-128, miR-328, miR -181, and miR-532 were downregulated. [score:9]
For example, miR-2137, miR-5130 and miR-5112 were highly expressed in heart tissues; miR-490, miR-491, miR-181, miR-362, miR-425, and miR-3104 were expressed at quite a low level (Ct value ∼ over 30), whereas 32 out of those 58 altered miRNA were expressed at an extremely low level in hearts and there were almost no Ct value detected by qPCR. [score:7]
Compared with grafts taken out on day 2 post-transplantation, the expression of miR-2137, miR-714, miR-744, miR -2137, miR -5130, miR -346, and miR -328 were slightly decreased, whilst the expression of miR-711 continued its upregulation in the I/R injured grafts. [score:7]
As compared with cells under normxia, miR-711, miR-714, miR-328, miR-346, miR-210, miR-744, miR-5130, miR-181a and miR-2137 were significantly over-expressed in hypoxia/reperfusion treated cardiomyocytes, while the expression of miR-491, miR-211, miR-532, miR-185, miR-425, miR-128, miR-24 was down-regulated (Figure 4B). [score:7]
The findings of our study demonstrate that miR-711, miR-2137 miR-705, miR-5130, miR-346, miR-714, and miR-744 were significantly upregulated (>2 fold change) in I/R injured hearts, while miR-210, miR-490, miR-491, miR-425, miR-423-3p, and miR-532-3p were downregulated. [score:7]
Performing computational analysis using TargetScan, two conserved genes, retrograde golgi transport homolog (RGP1) and pleckstrin and Sec7 domain containing (Psd), were predicted as targets of miR-2137, while another 144 genes including calmodulin binding transcription activator 1(Camta1) and furry homolog-like (Fryl) were predicted irrespective of site conservation. [score:5]
As expected, miR-2137, miR-210, miR-5130, and miR-328 were highly expressed in cardiomyocytes, while miR-490, miR-491, and miR-211 were expressed at a low level. [score:5]
Additionally, miR-2137, miR-1893, miR-744, miR-705 and miR-714 are highly expressed in heart tissue and cardiomyocytes as well, suggesting that these miRNA are important for cardiomyocytes survival and growth. [score:3]
Taken together, the increased expression of miR-2137 may play a role in I/R injury in heart transplantation through regulating CAMTA 1. miR-705, miR-714 and miR-744 have not been extensively investigated yet. [score:2]
However, there are no reports available on miR-2137 and 1893 regarding their functions. [score:1]
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2
[+] score: 52
In addition to the bioinformatics analyses, we found that choline -induced miR-2137 downregulation led to higher expression of several predicted mRNA targets. [score:8]
Based on the bioinformatics analyses, miR-2137 targets genes that are important for development, including the development of the mesodermal (GO: 0007498) and the ectodermal (GO: 0007398) layers. [score:5]
To determine if any of these predicted mRNA targets were affected by placental reduction of miR-2137, their expression was assessed using the data generated from the mRNA-sequencing experiment. [score:5]
Maternal Choline Supplementation Reduces Placental miR-2137 Abundance, with Downstream Effects on the Expression of Its Potential Target Genes. [score:5]
Based on TargetScan [28] prediction, miR-2137 has 170 mRNA targets with context++ score ≤−0.2. [score:5]
Placental miR-2137 was downregulated by 4X choline supplementation in the present study. [score:4]
Interestingly, micronutrient supplementation in a paternal undernutrition mouse mo del also changes miR-2137 expression in the offspring pancreas [64], indicating that this miRNA may be particularly sensitive to nutritional status. [score:3]
We also showed higher levels of global DNA methylation and suppression of miR-2137 abundance in placentas from dams supplemented with additional choline during gestation. [score:3]
Although significance was not achieved upon stratification by fetal sex, both female and male placentas from the 4X choline group exhibited lower expression of miR-2137 (fold change = 0.4 and 0.3, respectively). [score:3]
Among these miRNAs, the expression of miR-2137 was found to be significantly lower (fold change = 0.3; FDR = 0.125, P [unadjusted] = 2.05 × 10 [−4]) in response to 4X versus 1X maternal choline supplementation. [score:3]
Indeed, our bioinformatics analyses also indicated that miR-2137 impacts the development of these organs (GO: 0007399 and GO: 0007517). [score:2]
Taken together, changes induced by miR-2137 in response to a higher maternal choline intake may benefit placental development and offspring health. [score:2]
Collectively, these data support the involvement of placental miR-2137 in mediating the effect of maternal choline intake on various fetal developmental outcomes. [score:2]
Although miR-2137 has not been experimentally studied in the placenta, it has been examined in other tissues [60, 61, 62, 63]. [score:1]
Consistent with our bioinformatics analyses, these studies showed that altered miR-2137 abundance changes the function of different organs, including the heart and the brain, as well as processes related to cell signaling and apoptosis (both of which lost statistical significance in our bioinformatics analyses upon adjustment for multiple testing). [score:1]
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3
[+] score: 5
Moreover, some differentially up-regulated microRNAs (such as miR-466h-5p, miR-135a-1*, miR-2137, miR-223, miR-139-5p, miR-29b-1*, and miR-7a) displayed earlier in PR8 infected lungs than in BJ501 infected lungs. [score:4]
Nine microRNAs (miR-1, miR-1187, miR-133a, miR-133b, miR-155, miR-2137, miR-223, miR-30d and miR-574-3p) were selected for validation. [score:1]
[1 to 20 of 2 sentences]
4
[+] score: 3
The remaining eighteen differentially regulated miRNAs identified in the present study (miR-484, miR-677-3p, miR-690, miR-709, miR-1839-3p, miR-1902, miR-2137, miR-3077-5p, miR-3084-3p, miR-3090-5p, miR-3096b-3p, miR-3102-5p, miR-5627-5p, miR-6239, miR-6240, miR-6244, miR-6402, and miR-6538) have not previously been associated with ionizing radiation. [score:2]
Eighteen miRNAs found in the present study have not previously been associated with ionizing radiation, i. e. miR-484, miR-677-3p, miR-690, miR-709, miR-1839-3p, miR-1902, miR-2137, miR-3077-5p, miR-3084-3p, miR-3090-5p, miR-3096b-3p, miR-3102-5p, miR-5627-5p, miR-6239, miR-6240, miR-6244, miR-6402, and miR-6538. [score:1]
[1 to 20 of 2 sentences]
5
[+] score: 2
Thus, to further investigate relationships between increased plasma VEGF levels (Fig. 2) and the thirteen microRNAs (Table 1) that were downregulated following rIPC, expression levels of miR-6366, miR-711, miR-3960, miR-3072-5p, miR-2137, miR-762, miR-5112, and miR-149-3p were investigated in BM cells (Fig. 4). [score:2]
[1 to 20 of 1 sentences]
6
[+] score: 1
miRNAs (mmu-miR-21a-5p, mmu-miR-23a-3p, mmu-miR-2137, and mmu-let-7c-5p) were constant under our experimental conditions and therefore were selected for use in the normalization of all miRNA values. [score:1]
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