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miRBase |
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![]() 4 publications mentioning aae-mir-2aOpen access articles that are associated with the species Aedes aegypti and mention the gene name mir-2a. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary. |
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Other miRNAs from this paper: dme-mir-2a-1, dme-mir-2a-2, dme-mir-2b-1, dme-mir-2b-2, dme-mir-8, dme-mir-9a, dme-mir-12, dme-mir-14, dme-mir-277, dme-mir-281-1, dme-mir-283, dme-mir-281-2, dme-mir-34, dme-mir-79, dme-mir-210, dme-mir-304, dme-mir-306, dme-mir-9b, dme-let-7, dme-mir-2c, aga-let-7, aga-mir-14, aga-mir-210, aga-mir-277, aga-mir-281, aga-mir-283, aga-mir-2-1, aga-mir-2-2, aga-mir-79, aga-mir-8, aga-mir-9a, aga-mir-9b, dme-mir-375, dme-mir-981, dme-mir-989, dme-mir-996, aga-mir-34, aga-mir-12, aga-mir-996, aga-mir-989, aga-mir-306, aga-mir-981, aga-mir-375, aae-mir-277, aae-mir-8, aae-mir-306, aae-mir-281, aae-mir-989, aae-mir-14, aae-mir-34, aae-mir-996, aae-mir-12, aae-mir-981, aae-mir-283, aae-mir-210, aae-mir-79, aae-mir-375, aae-let-7, aae-mir-2b, aae-mir-2c, aae-mir-9a-1, aae-mir-9a-2, aae-mir-9b, aga-mir-2b, aga-mir-2c
There is an aga-miR-2 in miRBase (derived from two precursors aga-miR-2-1 and aga-miR-2-2), which is reverse complementary to ast-miR-2a.
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Four of the six Anopheline miRNAs (miR-12, miR-375, miR-2a, and miR-76) have conserved sequences in Ae.
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Sequence comparison showed that ast-miR-2a is not derived from aga-miR-2* because of the existence of multiple in dels/mismatches between the alignment of aga-miR-2 and aga-miR-2*.
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However, ast-miR-2a is reverse complementary to the aga-miR-2 reported in miRBase.
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Cloning results for ast-miR-2a, comparisons to dme-miR-2a, and miRscan predictions are all consistent.
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ast-miR-2a matches dme-miR-2a perfectly thus is named as miR-2a.
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The orientation of our cloned ast-mir-2a is consistent with the miRscan prediction based on An.
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One miRNA, ast-miR-2a, is worth noting.
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Other miRNAs from this paper: aae-mir-184, aae-mir-998, aae-mir-306, aae-mir-281, aae-mir-1889, aae-mir-989, aae-mir-11, aae-mir-1, aae-mir-1890, aae-mir-12, aae-mir-1891-1, aae-mir-1891-2, aae-mir-1175, aae-mir-1174, aae-mir-283, aae-mir-210, aae-mir-79, aae-let-7, aae-mir-2b, aae-mir-2c, aae-mir-263b, aae-mir-9b
Thus we refer to these hits miR-2a/2b/2c.
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4. It is difficult to distinguish between hits that match miR-2a, miR-2b, or miR-2c.
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3. MiR-13b and miR-2a/2b/2c are in a physically linked cluster.
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These miRNAs include aae-miR-2a, aae-miR-210, aae-miR-263b, aae-miR-281, and aae-miR-283.
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Other miRNAs from this paper: hsa-mir-31, hsa-mir-33a, hsa-mir-100, hsa-mir-141, hsa-mir-184, hsa-mir-200c, aga-mir-100, aga-mir-184, aga-mir-281, hsa-mir-33b, aga-mir-1175, aga-mir-989, aga-mir-1000, aae-mir-184, aae-mir-998, aae-mir-281, aae-mir-989, aae-mir-1175, aae-mir-31, aae-mir-33, aae-mir-100, aae-mir-1000-1, aae-mir-1000-2, aae-mir-2942, aae-mir-2943-1, aae-mir-2943-2, aae-mir-2944b, aga-mir-998, aga-mir-2944b, aga-mir-33, aga-mir-31
Sequence blast analysis suggests that miR-N6, miR-N17 and miR-N18 are separately found to be orthologous genes with miR-2a, miR-2942 and miR-2944b in Ae.
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Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-31, hsa-mir-10a, hsa-mir-10b, hsa-mir-34a, hsa-mir-210, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-1-1, hsa-mir-34b, hsa-mir-34c, hsa-mir-375, aae-bantam, aae-mir-276-1, aae-mir-306, aae-mir-281, aae-mir-980, aae-mir-989, aae-mir-11, aae-mir-1, aae-mir-34, aae-mir-305, aae-mir-12, aae-mir-999, aae-mir-1175, aae-mir-932, aae-mir-927, aae-mir-285, aae-mir-31, aae-mir-10, aae-mir-988, aae-mir-210, aae-mir-1000-1, aae-mir-1000-2, aae-mir-375, aae-let-7, aae-mir-2b, aae-mir-2c, aae-mir-276-2, aae-mir-2945
The 3′ trimmed (3′ Trim) class of isomiRs also varied in their abundance in response to infection; specifically miR-1175-3p, bantam-3p and miR-281-3p, showed significant induction, and miR34-5p, miR-2a-3p, and miR-927-3p significant reduction in infected mosquitoes (Fig. 4).
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