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7 publications mentioning hsa-mir-4454

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-4454. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 23
Among these: 3 miRNAs (i. e. miR-26a-5p, miR-143-3p, and miR-4454) were expressed in both RAA and LAA; 6 miRNAs (i. e. miR-30c-5p, miR-125b-5p, miR-133b, miR- 145-5p, miR-451a, and miR-4484) were expressed in only RAA; and 3 miRNAs (i. e. miR-1, miR-23b-3p, and miR-494) were expressed in only LAA. [score:7]
miR-4454 cannot be predicted using 5 target prediction databases, while, miR-4484 can be predicted using 2 target prediction databases. [score:5]
Most of these miRNAs were predicted by 5 target prediction databases except miR-4454 and miR-4484. [score:3]
To determine the probable biological function of the AF -associated miRNAs, we predicted the putative targets and pathways of 10 validated miRNAs (i. e. miR-1, miR-23b-3p, miR-26a-5p, miR-30c-5p, miR-125b-5p, miR-133b, miR-143-3p, miR-145-5p, miR-4454, and miR-4484) using the miRFocus database. [score:3]
Numerous putative target genes and pathways were identified for these miRNAs except miR-4454. [score:3]
According to the qRT-PCR data, miR-26a-5p, miR-143-3p, miR-4454 were AF -associated miRNAs found in both RAA and LAA tissues, while miR-30c-5p, miR-125b-5p, miR-133b, miR-145-5p, miR-4484 were AF -associated miRNAs found in only RAA tissues and miR-1, miR-23b-3p were found only in LAA tissues (Figure  5). [score:1]
To date, the miR-23, miR-125, miR-143, miR-145, miR-4454, and miR-4484 have not been described as participating in AF pathology. [score:1]
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2
[+] score: 15
Divergent molecular patterns of microRNA expression were observed in alternate lung lobes, specifically noted was disparate expression of miR-93 and miR-4454 in alveolar macrophages along with altered expression of miR-451a and miR-663a in bronchoalveolar lavage fluid. [score:7]
Potential targets identified via miRTarBase [21] of miR-93-5p include PTEN [26] and Il-8 [27], of miRNA-22-5p include PPARA and BMP7 [28] and HMGB1 [29], and of miR-4454 include TRAM2 and CCR4. [score:3]
However, in the lower lobe, four microRNAs were significantly altered including: miR-22-3p (P = 0.007), miR-30e-5p (P = 0.015), miR-4454 (P = 0.019), and miR-93-5p (P = 0.036). [score:1]
5% O [2] Three microRNAs were significantly different between regional macrophages miR-4443 (P = 0.003), miR-30e-5p (P = 0.018) and miR-4454 (P = 0.032). [score:1]
Ultimately, it remains to be determined if the specific microRNAs identified in this study, miR-93, miR-4454, miR-451a or miR-663a, function intracellularly, in a paracrine or endocrine manner in cell-to-cell communication, or are involved in trans-kingdom crosstalk with potential pathogens, or some combination of these processes. [score:1]
5% O [2] Three microRNAs were significantly different between regional macrophages miR-4443 (P = 0.003), miR-30e-5p (P = 0.018) and miR-4454 (P = 0.032). [score:1]
As a first approach, we examined the microRNA content of AM and identified a number of microRNAs that play roles related to innate immunity, inflammation or extracellular matrix remo deling including: miR-93-5p, miR-22-3p and miR-4454. [score:1]
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3
[+] score: 9
[17] hsa-miR-4454 Upregulated 12.8 0.000upregulation by the transcription factor NF-κBPositive correlation with disease activity in ulcerative colitis. [score:9]
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4
[+] score: 2
Hsa-miR-8069 was almost not detected in the BGISEQ-500 but had 0.9 million normalized intensity counts on the array platform, hsa-miR-4454 had 51.6 normalized reads on the BGISEQ-500 versus 1.9 million normalized counts on the microarrays, and hsa-miR-7977 had 343.2 normalized reads on the BGISEQ-500 versus 1.3 million normalized counts on the microarrays. [score:1]
Three miRNAs had high divergence between arrays and BGISEQ-500, among them hsa-miR-4454, which was high abundant in arrays but almost not detectable in BGISEQ-500. [score:1]
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5
[+] score: 2
There are 6 miRNAs common to the three LIM1863-dervided EVs - let-7a-3p*, let-7f-1-3p*, miR-451a, miR-574-5p*, miR-4454 and miR-7641 and 6 exosome miRNAs that enable discrimination between sMVs (miR-320a/b/c/d, miR-221-3p, and miR-200c-3p); we also report one miRNA (miR-98-5p) observed in sMVs but not in A33- or EpCAM-Exos. [score:1]
There are only 6 miRNA sequences common to all three EV subtypes, including three ‘passenger strand’ miRNAs (miRNA* sequences) (miR-451a, miR-4454, miR-7641, let-7a-3p*, let-7f-1-3p* and miR-574-5p*). [score:1]
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6
[+] score: 1
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-16-1, hsa-mir-17, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-23a, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-27a, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-100, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-16-2, mmu-mir-23b, mmu-mir-27b, mmu-mir-29b-1, mmu-mir-30a, mmu-mir-30b, mmu-mir-127, mmu-mir-128-1, mmu-mir-132, mmu-mir-133a-1, mmu-mir-188, mmu-mir-194-1, mmu-mir-195a, mmu-mir-199a-1, hsa-mir-199a-1, mmu-mir-200b, mmu-mir-205, mmu-mir-206, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-122, mmu-mir-30e, hsa-mir-199a-2, hsa-mir-199b, hsa-mir-205, hsa-mir-211, hsa-mir-212, hsa-mir-214, hsa-mir-217, hsa-mir-200b, hsa-mir-23b, hsa-mir-27b, hsa-mir-30b, hsa-mir-122, hsa-mir-128-1, hsa-mir-132, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-127, hsa-mir-138-1, hsa-mir-188, hsa-mir-194-1, hsa-mir-195, hsa-mir-206, mmu-mir-19b-2, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-mir-200a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-16-1, mmu-mir-16-2, mmu-mir-23a, mmu-mir-26a-1, mmu-mir-26b, mmu-mir-29a, mmu-mir-29c, mmu-mir-27a, mmu-mir-31, mmu-mir-351, hsa-mir-200c, mmu-mir-17, mmu-mir-19a, mmu-mir-100, mmu-mir-200c, mmu-mir-212, mmu-mir-214, mmu-mir-26a-2, mmu-mir-211, mmu-mir-29b-2, mmu-mir-199a-2, mmu-mir-199b, mmu-mir-19b-1, mmu-mir-138-1, mmu-mir-128-2, hsa-mir-128-2, mmu-mir-217, hsa-mir-194-2, mmu-mir-194-2, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-200a, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-379, mmu-mir-379, mmu-mir-133a-2, mmu-mir-133b, hsa-mir-133b, mmu-mir-412, mmu-mir-431, hsa-mir-431, hsa-mir-451a, mmu-mir-451a, mmu-mir-467a-1, hsa-mir-412, hsa-mir-485, hsa-mir-487a, hsa-mir-491, hsa-mir-503, hsa-mir-504, mmu-mir-485, hsa-mir-487b, mmu-mir-487b, mmu-mir-503, hsa-mir-556, hsa-mir-584, mmu-mir-665, mmu-mir-669a-1, mmu-mir-674, mmu-mir-690, mmu-mir-669a-2, mmu-mir-669a-3, mmu-mir-669c, mmu-mir-696, mmu-mir-491, mmu-mir-504, hsa-mir-665, mmu-mir-467e, mmu-mir-669k, mmu-mir-669f, hsa-mir-664a, mmu-mir-1896, mmu-mir-1894, mmu-mir-1943, mmu-mir-1983, mmu-mir-1839, mmu-mir-3064, mmu-mir-3072, mmu-mir-467a-2, mmu-mir-669a-4, mmu-mir-669a-5, mmu-mir-467a-3, mmu-mir-669a-6, mmu-mir-467a-4, mmu-mir-669a-7, mmu-mir-467a-5, mmu-mir-467a-6, mmu-mir-669a-8, mmu-mir-669a-9, mmu-mir-467a-7, mmu-mir-467a-8, mmu-mir-669a-10, mmu-mir-467a-9, mmu-mir-669a-11, mmu-mir-467a-10, mmu-mir-669a-12, mmu-mir-3473a, hsa-mir-23c, hsa-mir-4436a, mmu-mir-3473b, hsa-mir-4681, hsa-mir-3064, hsa-mir-4436b-1, hsa-mir-4790, hsa-mir-4804, hsa-mir-548ap, mmu-mir-3473c, mmu-mir-5110, mmu-mir-3473d, mmu-mir-5128, hsa-mir-4436b-2, mmu-mir-195b, mmu-mir-133c, mmu-mir-30f, mmu-mir-3473e, hsa-mir-6825, hsa-mir-6888, mmu-mir-6967-1, mmu-mir-3473f, mmu-mir-3473g, mmu-mir-6967-2, mmu-mir-3473h
ARPE_cont) Homo sapiens hsa-miR-4454 0.00806874 –2.15149 Homo sapiens hsa-miR-664a-5p 0.00933842 –1.71214 Homo sapiens HBII-316 0.0371439 –1.6763 Homo sapiens hsa-miR-188-3p 0.0050997 –1.67318 Homo sapiens hsa-mir-548al 0.0409855 –1.66795 Homo sapiens hsa-miR-548ap-3p 0.00270826 –1.62928 Homo sapiens hsa-miR-6888-5p 0.0244117 –1.55839 Homo sapiens hsa-miR-584-5p 0.00101538 –1.54123 Homo sapiens hsa-miR-4681 0.0273394 –1.53062 Homo sapiens hsa-miR-451a 0.0147813 –1.52959 Homo sapiens HBI-36 0.0477323 –1.51987 Homo sapiens hsa-miR-6825-5p 0.0137077 –1.51982 Homo sapiens hsa-miR-4790-5p 0.0229827 –1.51921 Homo sapiens hsa-mir-556 0.00579586 –1.5192 Homo sapiens hsa-mir-4804 0.018718 –1.4998 Homo sapiens U73a 0.0395006 –1. [score:1]
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7
[+] score: 1
01 Down 4.40E-07 hsa-miR-4488 5.95 Up 4.10E-35 hsa-miR-1269b −6.74 Down 3.15E-06 hsa-miR-296-5p 5.84 Up 3.88E-78 hsa-miR-3674 −6.74 Down 3.16E-06 hsa-miR-4454 5.19 Up 3.07E-85 hsa-miR-3910 −6.74 Down 3.17E-06 hsa-miR-4687-3p 4.37 Up 8.32E-26 hsa-miR-642a-3p −6.74 Down 5.10E-32 hsa-miR-3654 3.38 Up 1.21E-25 hsa-miR-486-5p −6.46 Down 2.81E-100 hsa-miR-577 2.94 Up 8.64E-05 hsa-miR-203 −6.30 Down 3.19E-89 hsa-miR-4508 2.9 Up 5.94E-06 hsa-miR-1277-3p −6.16 Down 3.01E-41 hsa-miR-3687 2.49 Up 2.04E-05 hsa-miR-1277-5p −5. [score:1]
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