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1 publications mentioning ola-let-7g

Open access articles that are associated with the species Oryzias latipes and mention the gene name let-7g. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 27
Recently, let-7, miR-122 and miR-143 have been shown to have tumor suppressive activity, and de-regulated let-7 expression has been associated with cancer [14], [16], [41]. [score:6]
All let-7 members share a similar seed region which regulates the interaction between miRNA and its target genes, so it is generally believed that let-7 family imposes similar biological functions among different species. [score:4]
Moreover, let-7 transgenic mice study indicated an impairment of glucose tolerance through the deregulation of insulin receptor (Insr) and insulin receptor substrate 2 (Irs2) in liver [34], suggesting that the hypoxia -mediated let-7a suppression may result in the dysfunction of medaka liver under hypoxia. [score:4]
For example, the first known miRNAs, lin-4 and let-7, were found to play a major role in developmental timing [30], [31]. [score:2]
Let-7 is one of the most highly expressed across all tissues in our data. [score:2]
For example, mature let-7 regulates cell proliferation and differentiation and is also highly conserved across animal species [32]. [score:2]
Furthermore, let-7 regulated ageing of testis stem cell niche in drosophila [35]. [score:2]
There is ample reports that demonstrated the importance of let-7 in different biological functions of brain, liver and gonads [33]– [35]. [score:1]
Sabrina et al reported that the introduction of let-7 caused the activation of Toll-like receptor 7, resulting in neurodegeneration in mouse’s brain [33]. [score:1]
But, it has been reported that let-7 can be induced by HIF-1α in response to hypoxia in vascular endothelial cell (HUVECs) [18]. [score:1]
Also, let-7 was found to control glucose homeostasis and insulin sensitivity in liver [34]. [score:1]
Only 3 O. melastigma miRNAs (Let-7, miR-1 and miR-124) were highly conserved across all mo del animals, 52 were conserved in all of the vertebrate mo dels, and 31 were found to be teleost-specific (Table 4). [score:1]
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