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6 publications mentioning gga-mir-196-4

Open access articles that are associated with the species Gallus gallus and mention the gene name mir-196-4. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 10
miR-196 acts upstream of the homeobox (Hox) gene to define the boundary of Hox gene expression along the anterior-posterior embryonic axis. [score:3]
Unilaterally localized injection of antagomiR196 into the presomatic mesoderm in ova leads to vertebral transformations at the cervical-thoracic boundary, and thus high-frequency ectopia of the last cervical vertebra (c14) occurs as decreased miR-196 expression gives expands the limit of homeoboxB8 (Hoxb8) transcripts in more anterior somites. [score:3]
Effects caused by miRNAs on somite development and embryonic morphology have been reported previously, such as those caused by miR-196 [77]. [score:2]
Whether this data agrees with the mechanism of regulation of Hox targets with miR-196 requires further investigation since little evidence for its role in embryogenesis has been found. [score:2]
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[+] score: 5
In addition, gga-miR-196, a Hox-related gene, is involved in the regulation of normal development and is mutated in some diseases and malformations [32]. [score:5]
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[+] score: 4
Furthermore, expression of several miRs, including miR-10b and miR-196, was detected in the developing limb and found to be involved in the specification of limb development [13, 14]. [score:4]
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[+] score: 4
[3] Start (pb) Gene ID [4] Symbol Description Ensembl ID [5]238.06 Mb/ 86 cM31.78-38.35 Mb732,053,542777943MIR148AmicroRNA mir-148aENSGALG00000018281732,326,549420629SKAP2src kinase associated phosphoprotein 2ENSGALG00000011051732,584,271-gga-mir-1732microRNA-mir-1732ENSGALG00000025254732,586,148777944MIR196-2microRNA mir-196-2ENSGALG00000018282732,879,740395490TAX1BP1Tax1 (human T-cell leukemia virus type I) binding protein 1ENSGALG00000011123733,469,922428436TRILTLR4 interactor with leucine-rich repeats-733,567,743428437CHN2chimerin (chimaerin) 2, involved in Rac signallingENSGALG00000011164333,985,086420640ANKRD28ankyrin repeat domain 28 (promotes cell migration)ENSGALG00000011226334,275,134395109RFTN1raftlin, lipid raft linker 1 (B cell-specific major lipid raft protein)ENSGALG00000011241334,473,226420645PLCL2phospholipase C-like 2, involved in MAPK pathway and PI3K signallingENSGALG00000011248335,783,173420649RAB5ARAB5A, member RAS oncogene family, involve in endocytosisENSGALG00000011272337,167,138420654NKIRAS1NFKB inhibitor interacting Ras-like 1ENSGALG00000011289193.38 Mb/ 21 cM2.71- 3.80 Mb12,823,176417489LAT2/ NTAL_CHICKLinker for activation of T cells family, member 2ENSGALG00000001305173,408,203395930RABEP1/RABAPTIN1rabaptin, RAB GTPase binding effector protein 1ENSGALG00000001737230.84 Mb/ 1 cM0.72- 1.321843,249428208HIVEP3Human immunodeficiency virus type I enhancer binding protein 3ENSGALG00000000635 262.95 Mb/ 29 cM2.60-3.31 Mb 2,896,047-gga-mir-205amicroRNA-mir-205aENSGALG0000001831212,976,923419862TRAF3IP3TRAF3 interacting protein 3, TNF-receptor associated interacting proteinENSGALG00000001373 1 2,989,458 419863 IRF6 Interferon regulatory factor 6 ENSGALG00000001405 [1] Chicken chromosome. [score:4]
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[+] score: 3
Most of the changed microRNAs are involved in development (especially in the embryonic development) and some examples of them are miRNA-222, miRNA-383, miRNA-126, miRNA-133, miRNA-30, miRNA-10a, miRNA-196 and miRNA-18b. [score:3]
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[+] score: 2
In ovo application of antagomiRs indicates a role for miR-196 in patterning the chick axial skeleton through Hox gene regulation. [score:2]
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