Stem-loop hsa-mir-10b

Accession

MI0000267

Symbol

HGNC: MIR10B

Description

Homo sapiens hsa-mir-10b precursor miRNA

Literature search

346 open access papers mention hsa-mir-10b
(2018 sentences)

Sequence

1086103 reads, 3750 reads per million, 146 experiments

ccagagguuguaacguugucuauauaUACCCUGUAGAACCGAAUUUGUGugguauccguauagucACAGAUUCGAUUCUAGGGGAAUauauggucgaugcaaaaacuuca
...((((((....(((((.((((((((.((((.(((((.((((((((((.(.(((....))).))))))))))).))))))))).)))))))).)))))....)))))).

Structure

cca      guaa     u        A    G     C          u g   c 
   gagguu    cguug cuauauaU CCCU UAGAA CGAAUUUGUG g uau c
   ||||||    ||||| |||||||| |||| ||||| |||||||||| | |||  
   cuucaa    guagc gguauaUA GGGG AUCUU GCUUAGACAc u aua g
--a      aaac     u        A    -     A          - g   u 

Annotation confidence Not enough data

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Michael et al. subsequently verified expression of miR-10b in human [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

chr2: 176150303-176150412 [+]

Disease association

hsa-mir-10b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-10b-5p

• Accession: MIMAT0000254
• Description: Homo sapiens hsa-miR-10b-5p mature miRNA
• Sequence: 27 - UACCCUGUAGAACCGAAUUUGUG - 49
• Evidence: experimental ; cloned [2-4]

Mature hsa-miR-10b-3p

• Accession: MIMAT0004556
• Description: Homo sapiens hsa-miR-10b-3p mature miRNA
• Sequence: 66 - ACAGAUUCGAUUCUAGGGGAAU - 87
• Evidence: experimental ; cloned [3]

References

1. PubMed ID: 14573789
   Reduced accumulation of specific microRNAs in colorectal neoplasia
   "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
   "Mol Cancer Res (2003) 1:882-891


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


4. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540