Stem-loop hsa-mir-378a

Accession

MI0000786

Symbol

HGNC: MIR378A

Description

Homo sapiens hsa-mir-378a precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR378A is a small RNA molecule that has been found to be positively correlated with age, along with miR-34a and miR-320b, and negatively associated with age, along with miR-20a, miR-30b, miR-106b, miR-191, miR-301a, and miR-374a [PMC6196565]. The UCCU sequence of RNA has been chosen for analysis due to its presence in small RNAs such as miR23a, MIR378A, and miR344 [PMC6004406]. MIR378A has been found to be downregulated in the sperm of fathers with high paternal depressive symptoms compared to fathers without such symptoms [PMC8157381]. Additionally, MIR378A has been detected in extracellular vesicles (EVs) during the differentiation of human embryonic stem cells into cardiac cells [PMC7912193]. EVs have been shown to contain several other microRNAs (miRNAs) along with MIR378A [PMC7912193]. The levels of primary MIR378A have been determined using quantitative real-time polymerase chain reaction (qRT-PCR) along with 18 s rRNA [PMC8393456]. References: [PMC6196565] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196565/ [PMC6004406] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004406/ [PMC8157381] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157381/ [PMC7912193] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912193/ [PMC8393456] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393456/

Literature search

212 open access papers mention hsa-mir-378a
(1262 sentences)

Sequence

5214209 reads, 6859 reads per million, 154 experiments

agggCUCCUGACUCCAGGUCCUGUGUguuaccuagaaauagcACUGGACUUGGAGUCAGAAGGCcu
(((.((.((((((((((((((.((((..(........)..)))).)))))))))))))).)).)))

Structure

   g  C              U    gu acc 
agg CU CUGACUCCAGGUCC GUGU  u   u
||| || |||||||||||||| ||||  |    
ucC GA GACUGAGGUUCAGG CAcg  a   a
   G  A              U    au aag 

Annotation confidence High

Comments

miR-422b was the most abundant miRNA cloned from human promyelocytic leukemia (HL-60) cells [2]. The sequence originates from the opposite arm of the human homologue of previously identified mouse mir-378 [1]. Landgraf et al. show that the 3' product (previously called miR-422b) is the predominant one [3]. Further, mir-378 and mir-422a loci are unrelated. miR-422b is thus renamed miR-378 here.

Genome context

chr5: 149732825-149732890 [+]

Disease association

hsa-mir-378a is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-378a is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-378a is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-378a-5p

• Accession: MIMAT0000731
• Description: Homo sapiens hsa-miR-378a-5p mature miRNA
• Sequence: 5 - CUCCUGACUCCAGGUCCUGUGU - 26
• Evidence: experimental ; cloned [3]

Mature hsa-miR-378a-3p

• Accession: MIMAT0000732
• Description: Homo sapiens hsa-miR-378a-3p mature miRNA
• Sequence: 43 - ACUGGACUUGGAGUCAGAAGGC - 64
• Evidence: experimental ; cloned [2-3], Northern [2]

References

1. PubMed ID: 15325244
   Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
   "Kasashima K, Nakamura Y, Kozu T"
   "Biochem Biophys Res Commun (2004) 322:403-410


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 15538371
   A pancreatic islet-specific microRNA regulates insulin secretion
   "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
   "Nature (2004) 432:226-230