Stem-loop mmu-mir-378a

Accession

MI0000795

Symbol

MGI: Mir378a

Description

Mus musculus mmu-mir-378a precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

Mmu-mir-378 is a differentially expressed miRNA that plays important roles in immune function, signal pathway induction, and nutrition metabolism [PMC4136864]. It has been found to have a target site in the mRNA corresponding to the BCL7A gene [PMC2684643]. Mmu-mir-378 is one of the 10 differentially expressed miRNAs with the highest degree in a network analysis [PMC6833270]. It has also been identified as one of the miRNAs that are upregulated in white adipose tissue (WAT) in response to high-fat diet (HFD) feeding [PMC4571067]. Mmu-mir-378 is downregulated during HFD-induced obesity, which is consistent with previous studies [PMC3319598]. It has been shown to have potential binding sites with the 3'-UTR of Caspase-3 mRNA [PMC5037706]. Mmu-mir-378 is one of the miRNAs that are downregulated in baicalin-treated mice compared with UVB irradiated mice and predicted to be related to DNA repair signaling pathway [PMC3597329]. It has also been identified as one of the dominantly expressed miRNAs in Brucella-infected cells and mock-infected cells [PMC3421232]. Mmu-mir-378 is T3-responsive and its expression can be induced by T3 treatment in primary mouse hepatocytes [PMC7977473]. Overall, mmu-mir-378 plays diverse roles and its expression can be regulated by various factors.

Literature search

86 open access papers mention mmu-mir-378a
(897 sentences)

Sequence

9042113 reads, 10317 reads per million, 107 experiments

agggCUCCUGACUCCAGGUCCUGUGUguuaccucgaaauagcACUGGACUUGGAGUCAGAAGGccu
(((.((.((((((((((((((.((((..(........)..)))).)))))))))))))).)).)))

Structure

   g  C              U    gu acc 
agg CU CUGACUCCAGGUCC GUGU  u   u
||| || |||||||||||||| ||||  |    
ucc GA GACUGAGGUUCAGG CAcg  a   c
   G  A              U    au aag 

Annotation confidence High

Genome context

chr18: 61397835-61397900 [-]

Mature mmu-miR-378a-5p

• Accession: MIMAT0000742
• Description: Mus musculus mmu-miR-378a-5p mature miRNA
• Sequence: 5 - CUCCUGACUCCAGGUCCUGUGU - 26
• Evidence: experimental ; cloned [1-2], Illumina [3-4]

Mature mmu-miR-378a-3p

• Accession: MIMAT0003151
• Description: Mus musculus mmu-miR-378a-3p mature miRNA
• Sequence: 43 - ACUGGACUUGGAGUCAGAAGG - 63
• Evidence: experimental ; cloned [2], Illumina [3-4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15538371
   A pancreatic islet-specific microRNA regulates insulin secretion
   "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
   "Nature (2004) 432:226-230


3. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


4. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009