Accession
MI0001518
Symbol
HGNC:
MIR18B
Description
Homo sapiens
hsa-mir-18b precursor miRNA mir-17
Gene
family?
family?
RF00051;
mir-17
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR18B is a microRNA that has been implicated in various diseases and biological processes. It is part of a cluster of miRNAs, including miR17, miR20a, miR20b, miR18a, and miR106a, which have been extensively studied in the context of cancer [PMC3544584]. In polycystic ovary syndrome (PCOS), MIR18B has been found to be upregulated in the follicular fluid of PCOS patients compared to normal women [PMC6956659]. Additionally, MIR18B has been reported to repress MDM2 and activate p53 [PMC9791775]. In cutaneous squamous cell carcinoma (CSCC), MIR18B is one of the upregulated miRNAs in CSCC samples [PMC3341860]. Other studies have shown that MIR18B is involved in cell cycle regulation and inflammation-associated conditions [PMC9555085] [PMC7432402]. In breast cancer patients undergoing neoadjuvant therapy (NAT), high expression of MIR18B has been associated with response to treatment [PMC8537499]. Furthermore, dysregulation of MIR18B expression has been proposed as a prognostic marker for mantle cell lymphoma (MCL) and nasopharyngeal carcinoma (NPC) patients [PMC6183594] [PMC6368411]. Additionally, it has been suggested that MIR18B may play a role in the positive regulation of Orai3 expression through its interaction with other microRNAs such as miR18a [PMC9817886].
Literature search
106 open access papers mention hsa-mir-18b
(268 sentences)
(268 sentences)
Sequence
234541
reads,
1926
reads per million, 99 experiments
uguguUAAGGUGCAUCUAGUGCAGUUAGugaagcagcuuagaaucuacUGCCCUAAAUGCCCCUUCUGGCa
(((...((((.((((.(((.(((((.((................))))))).))).)))).))))...)))
(((...((((.((((.(((.(((((.((................))))))).))).)))).))))...)))
Structure
guU U C U U ugaagca ugu AAGG GCAU UAG GCAGU AG g ||| |||| |||| ||| ||||| || aCG UUCC CGUA AUC CGUca uc c GUC C A C - uaagauu
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chrX: 134170041-134170111 [-]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-18b
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-18b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-18b-5p
| Accession | MIMAT0001412 |
| Description | Homo sapiens hsa-miR-18b-5p mature miRNA |
| Sequence | 6 - UAAGGUGCAUCUAGUGCAGUUAG - 28 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-18b-3p
| Accession | MIMAT0004751 |
| Description | Homo sapiens hsa-miR-18b-3p mature miRNA |
| Sequence | 49 - UGCCCUAAAUGCCCCUUCUGGC - 70 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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