Accession
MI0001519
Symbol
HGNC:
MIR20B
Description
Homo sapiens
hsa-mir-20b precursor miRNA mir-17
Gene
family?
family?
RF00051;
mir-17
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR20B is a microRNA that is found to have low expression in PC3 GSCs and U87MG GSCs, which are characterized by high glycolytic activity and expression of CD44 and ALDH1A3 mesenchymal markers [PMC7463503]. In TE3 esophageal cancer cells, transfection of MIR20B affected autophagy [PMC5302951]. Overexpression of the miR‐106a‐363 cluster, which includes MIR20B, exhibited an anti-proliferative effect on cancer cells [PMC8410538]. Upregulation of MIR20B reduced metastasis of 4T1 breast cancer cells to the lung, suggesting its role as a tumor suppressor miRNA [PMC7062679]. The rs13897515 polymorphism of the MIR20B gene has been associated with differences in Aβ1-42 levels in the cerebrospinal fluid [PMC9792503]. The ADNI database was queried for SNPs in or near the MIR20B gene on ChrXq26.2 [PMC9054681]. A miRNA peak downstream of MIR20B was highly represented in the testis [PMC3576234]. In a study predicting module genes, MIR106A, MIR106B, MIR20B, and MIR519D were identified as potential miRNAs [PMC9208509]. Individual assays also studied miR15b, MIR20B, miR122, miR-140-3p, miR-185, miR-192, miR-375, miR-483-5p and miR885-5P [PMC3956820]. In relation to Alzheimer's disease (AD), when the APOE ε4 allele was absent, higher levels of MIR20B were associated with reduced probability of AD and increased probability of normal cognitive function [PMC9054681].
Literature search
208 open access papers mention hsa-mir-20b
(659 sentences)
(659 sentences)
Sequence
12866
reads,
152
reads per million, 136 experiments
aguacCAAAGUGCUCAUAGUGCAGGUAGuuuuggcaugacucuACUGUAGUAUGGGCACUUCCAGuacu
(((((..(((((((((((.(((((..((((.......))))...))))).)))))))))))...)))))
(((((..(((((((((((.(((((..((((.......))))...))))).)))))))))))...)))))
Structure
-CA G -GU uu
aguac AAGUGCUCAUA UGCAG AGuu g
||||| ||||||||||| ||||| |||| g
ucauG UUCACGGGUAU AUGUC ucag c
ACC G Auc ua
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chrX: 134169809-134169877 [-]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-20b
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-20b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-20b is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-20b is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-20b-5p
| Accession | MIMAT0001413 |
| Description | Homo sapiens hsa-miR-20b-5p mature miRNA |
| Sequence | 6 - CAAAGUGCUCAUAGUGCAGGUAG - 28 |
| Evidence |
experimental
array-cloned [2], cloned [3-5] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-20b-3p
| Accession | MIMAT0004752 |
| Description | Homo sapiens hsa-miR-20b-3p mature miRNA |
| Sequence | 44 - ACUGUAGUAUGGGCACUUCCAG - 65 |
| Evidence |
experimental
cloned [4] |
| Database links |
|
| Predicted targets |
|
References
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