miRBase entry: hsa-mir-519c

Stem-loop hsa-mir-519c

Accession

MI0003148

Symbol

HGNC: MIR519C

Description

Homo sapiens hsa-mir-519c precursor miRNA mir-515

Gene
family?

RF00639; mir-515

Literature search

27 open access papers mention hsa-mir-519c
(69 sentences)

Sequence

106 reads, 15 reads per million, 22 experiments

ucucagccugugaccCUCUAGAGGGAAGCGCUUUCUGuugucugaaagaaaagAAAGUGCAUCUUUUUAGAGGAUuacaguuugaga
((((((.((((((.((((((((((((.(((((((((....(((...)))..))))))))).)))))))))))).)))))).))))))

Structure

      c      c            A         Guug   g 
ucucag cuguga cCUCUAGAGGGA GCGCUUUCU    ucu  
|||||| |||||| |||||||||||| |||||||||    ||| a
agaguu gacauU GGAGAUUUUUCU CGUGAAAga    aga  
      u      A            A         --aa   a

Annotation confidence High

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Comments

The 5' arm of this precursor expresses a product related to miR-526 (previously named miR-526c here). Landgraf et al. confirm mature miRNA expression from both arms of the precursor [2], leading to the -5p, -3p designations. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr19: 53686469-53686555 [+]

Clustered miRNAs

8 other miRNAs are < 10 kb from hsa-mir-519c

Name	Accession	Chromosome	Start	End	Strand	Confidence

Disease association

hsa-mir-519c is associated with one or more human diseases in the Human microRNA Disease Database

Disease	Description	Category	PubMed ID

Database links

Mature hsa-miR-519c-5p

Accession	MIMAT0002831
Description	Homo sapiens hsa-miR-519c-5p mature miRNA
Sequence	16 - CUCUAGAGGGAAGCGCUUUCUG - 37
Evidence	experimental array-cloned [1], cloned [2]
Database links
Predicted targets

Mature hsa-miR-519c-3p

Accession	MIMAT0002832
Description	Homo sapiens hsa-miR-519c-3p mature miRNA
Sequence	54 - AAAGUGCAUCUUUUUAGAGGAU - 75
Evidence	experimental array-cloned [1]

References

PubMed ID: 17604727
A mammalian microRNA expression atlas based on small RNA library sequencing
"Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
"Cell (2007) 129:1401-1414

PubMed ID: 15965474
Identification of hundreds of conserved and nonconserved human microRNAs
"Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
"Nat Genet (2005) 37:766-770