Stem-loop hsa-mir-1185-1

Accession

MI0003844

Symbol

HGNC: MIR1185-1

Description

Homo sapiens hsa-mir-1185-1 precursor miRNA

Literature search

4 open access papers mention hsa-mir-1185-1
(4 sentences)

Sequence

2574 reads, 62 reads per million, 72 experiments

uuugguacuugaagAGAGGAUACCCUUUGUAUGUUcacuugauuaauggcgaAUAUACAGGGGGAGACUCUUAUuugcguaucaaa
.(((((((.(((((((((..(.((((((((((((((.((........)).)))))))))))))))..))))).)))).))))))).

Structure

u       u    -     GA A              a  uga 
 uugguac ugaa gAGAG  U CCCUUUGUAUGUUc cu   u
 ||||||| |||| |||||  | |||||||||||||| ||    
 aacuaug guuU UUCUC  A GGGGGACAUAUAag gg   u
a       c    A     AG -              c  uaa 

Annotation confidence High

Comments

This sequence was proposed as a miRNA candidate by Berezikov et al by RAKE analysis [1], and validated by cloning independently by Subramanian et al [2].

Genome context

chr14: 101042977-101043062 [+]

Clustered miRNAs

15 other miRNAs are < 10 kb from hsa-mir-1185-1

Disease association

hsa-mir-1185-1 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-1185-5p

• Accession: MIMAT0005798
• Description: Homo sapiens hsa-miR-1185-5p mature miRNA
• Sequence: 15 - AGAGGAUACCCUUUGUAUGUU - 35
• Evidence: experimental ; cloned [2]

Mature hsa-miR-1185-1-3p

• Accession: MIMAT0022838
• Description: Homo sapiens hsa-miR-1185-1-3p mature miRNA
• Sequence: 53 - AUAUACAGGGGGAGACUCUUAU - 74
• Evidence: not_experimental

References

1. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298


2. PubMed ID: 17922033
   MicroRNA expression signature of human sarcomas
   "Subramanian S, Lui WO, Lee CH, Espinosa I, Nielsen TO, Heinrich MC, Corless CL, Fire AZ, van de Rijn M"
   "Oncogene (2008) 27:2015-2026