Stem-loop hsa-mir-876

Accession

MI0005542

Symbol

HGNC: MIR876

Description

Homo sapiens hsa-mir-876 precursor miRNA

Gene family

MIPF0000430; mir-876

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR876 is a gene that encodes two MicroRNAs, miR-876-3p and miR-876-5p [PMC3210160]. A bivariate GWAS study was conducted in Chinese and US Caucasians, focusing on femoral neck bone geometry and body lean mass, which are major risk factors for musculoskeletal disease [PMC3706967]. In Chinese individuals, MIR876 was found to be associated with bone geometry and ALM (appendicular lean mass), but these associations were not replicated in Caucasians [PMC3210160]. A group of 11 contiguous SNPs located within genomic regions containing MIR876 and MIR873 were strongly associated with ALM-BR (appendicular lean mass to body ratio) in Chinese individuals [PMC3210160]. The exact mechanisms by which MIR876 and MIR873 are involved in co-regulating bone and muscle metabolism remain unclear [PMC3210160'>PMC3210160]. In a bivariate GWAS for ALM and femoral neck bone geometry, 13 SNPs located within or near HK2, UMOD, MIR876, and MIR873 showed strong associations with both traits [PMC3210160]. Two of these SNPs were located in the promoter region of the MIR876 gene [PMC3210160]. Methylation-sensitive microRNAs including miR27A, miR-193a-5p (MIR193A), and miR-876-3p (MIR876) were also identified in the study [PMC9582525]. Additionally, pGBMs (primary glioblastomas) often exhibit a recurrent deletion on chromosome 9p21.3 that includes the MIR876 gene [PMC6388501].

Literature search

11 open access papers mention hsa-mir-876
(15 sentences)

Sequence

724 reads, 93 reads per million, 59 experiments

ugaagugcugUGGAUUUCUUUGUGAAUCACCAuaucuaagcuaauguggUGGUGGUUUACAAAGUAAUUCAuagugcuuca
((((((((((((((((.((((((((((((((((..(.........)..)))))))))))))))).))))))))))))))))

Structure

                U                au uaa 
ugaagugcugUGGAUU CUUUGUGAAUCACCAu  c   g
|||||||||||||||| ||||||||||||||||  |   c
acuucgugauACUUAA GAAACAUUUGGUGGUg  g   u
                U                gu uaa 

Annotation confidence High

Genome context

chr9: 28863626-28863706 [-]

Disease association

hsa-mir-876 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-876-5p

• Accession: MIMAT0004924
• Description: Homo sapiens hsa-miR-876-5p mature miRNA
• Sequence: 11 - UGGAUUUCUUUGUGAAUCACCA - 32
• Evidence: experimental ; cloned [1]

Mature hsa-miR-876-3p

• Accession: MIMAT0004925
• Description: Homo sapiens hsa-miR-876-3p mature miRNA
• Sequence: 50 - UGGUGGUUUACAAAGUAAUUCA - 71
• Evidence: experimental ; cloned [1]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414