Bta-mir-196b is a microRNA that has been found to be under-expressed in cattle, specifically in Wagyu cattle compared to Holstein cattle. This suggests that bta-mir-196b may play a role in regulating fat deposition in beef through the stimulation of adipocyte differentiation via the PPAR pathway, similar to miR-519d [PMC5341059]. Bta-mir-196b, along with bta-miR-874, directly regulates the expression of PPARα and RXRα, two important transcription factors in the PPAR signaling pathway [PMC5341059]. These microRNAs may also regulate lipid metabolism, glycerophospholipid metabolism, adipocyte differentiation, and glucose metabolism by inhibiting the expression of various genes involved in the PPAR pathway [PMC5341059]. Additionally, bta-mir-196b has been implicated in endothelial cell proliferation and bta-miR-146b has been associated with bacteria recognition and regulation of inflammatory response during Mycobacterium avium subspecies paratuberculosis infection [PMC6162677]. Overall, bta-mir-196b appears to be involved in various biological processes related to fat deposition and metabolic regulation.
- uc uU U C ucca aacugg ggugau AGGUAGU UC UGUUGUUGGGA c |||||| |||||| ||||||| || ||||||||||| uugacu ucauua uccguca ag acgacagcucu c g -- cu c c cuuu
Accession | MIMAT0009256 |
Description | Bos taurus bta-miR-196b mature miRNA |
Sequence | 16 - UAGGUAGUUUCCUGUUGUUGGGA - 38 |
Evidence | not_experimental |
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