miRBase entry: hsa-mir-24-2

Stem-loop hsa-mir-24-2


Accession
MI0000081
Symbol
HGNC: MIR24-2
Description
Homo sapiens hsa-mir-24-2 precursor miRNA
Gene family
MIPF0000041; mir-24

Literature search
343 open access papers mention hsa-mir-24-2
(2148 sentences)

Sequence

805083 reads, 3119 reads per million, 144 experiments
cucugccucccgUGCCUACUGAGCUGAAACACAGuugguuuguguacacUGGCUCAGUUCAGCAGGAACAGgg
(((((..(((.((....(((((((((..((((((.....))))))....)))))))))...)).))).)))))

Structure
     cc   c  GCCU         --AA      u 
cucug  ucc gU    ACUGAGCUG    ACACAG u
|||||  ||| ||    |||||||||    |||||| g
ggGAC  AGG CG    UGACUCGGU    uguguu g
     -A   A  -ACU         caca      u 


Annotation confidence High
Do you think this miRNA is real?
Comments
mir-24-2 was identified independently by two groups. This sequence was named miR-24 precursor-19 in reference [2].

Genome context
chr19: 13836287-13836359 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-24-2
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-24-2 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-24-2 is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-24-2 is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-24-3p

Accession MIMAT0000080
Description Homo sapiens hsa-miR-24-3p mature miRNA
Sequence 50 - UGGCUCAGUUCAGCAGGAACAG - 71
Evidence experimental
cloned [1,4-7], Northern [1], Illumina [8]
Database links
Predicted targets

Mature hsa-miR-24-2-5p

Accession MIMAT0004497
Description Homo sapiens hsa-miR-24-2-5p mature miRNA
Sequence 13 - UGCCUACUGAGCUGAAACACAG - 34
Evidence experimental
cloned [6]
Database links
Predicted targets

References

  1. PubMed ID: 11679670
    Identification of novel genes coding for small expressed RNAs
    "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
    "Science (2001) 294:853-858

  2. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  3. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  4. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  5. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  6. PubMed ID: 20158877
    Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
    Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov V, Kiang LS, Tanavde V
    BMC Genomics (2010) 11:S6

  7. PubMed ID: 11914277
    miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
    "Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G"
    "Genes Dev (2002) 16:720-728

  8. PubMed ID: 15978578
    Identification of human fetal liver miRNAs by a novel method
    "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
    "FEBS Lett (2005) 579:3849-3854