miRBase entry: hsa-mir-32

Stem-loop hsa-mir-32


Accession
MI0000090
Symbol
HGNC: MIR32
Description
Homo sapiens hsa-mir-32 precursor miRNA
Gene family
MIPF0000069; mir-32

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR32 is a microRNA that has been found to be upregulated in thyroid cancer compared to benign thyroid tumors in a microarray study [PMC4315163]. However, the functional implications of MIR32 in papillary thyroid carcinoma (PTC) are still unknown [PMC4315163]. Studies have shown that MIR32 can directly inhibit the RNA virus primate foamy retrovirus type 1, which is comparable to HIV1, at the protein level [PMC7833564]. Additionally, MIR32 has been found to have a supplementary degradative function in the coding region for influenza PB1 [PMC7833564]. In the context of Tmprss2 as a critical drug target, it has been suggested that MIR32 could be employed as a potential therapeutic for specific suppression of Tmprss2 [PMC7833564]. Differential gene analysis identified MIR32 as one of the top 40 differential genes in thyroid cancer [PMC9730279]. In experimental studies, MIR32 mimics and antagomirs were transfected into 293 T cells to investigate their effects on PIKfyve-3' UTR Wt and PIKfyve-3' UTR Mut expression levels [PMC6967090]. Real-time PCR assays were used to assess the expression levels of various miRNAs including MIR32 in different experimental conditions [PMC3424561] and it was found that miRNAs such as miR140, miR141, and miR184 showed decreased abundance while miRNAs such as miR150 and miR146 showed increased abundance in knockout mice compared to wild-type mice [PMC10001410].

Literature search
103 open access papers mention hsa-mir-32
(578 sentences)

Sequence

74946 reads, 639 reads per million, 124 experiments
ggagaUAUUGCACAUUACUAAGUUGCAuguugucacggccucaaugCAAUUUAGUGUGUGUGAUAUUUuc
(((((((((((((((.(((((((((((((..((....))..).)))))))))))))))))))))))))))

Structure
               U            - uu  c 
ggagaUAUUGCACAU ACUAAGUUGCAu g  gu a
||||||||||||||| |||||||||||| |  ||  
cuUUUAUAGUGUGUG UGAUUUAACgua c  cg c
               -            a uc  g 


Annotation confidence High
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Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chr9: 109046229-109046298 [-]

Disease association
hsa-mir-32 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-32 is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-32 is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-32-5p

Accession MIMAT0000090
Description Homo sapiens hsa-miR-32-5p mature miRNA
Sequence 6 - UAUUGCACAUUACUAAGUUGCA - 27
Evidence experimental
cloned [1-2], Northern [1]
Database links
Predicted targets

Mature hsa-miR-32-3p

Accession MIMAT0004505
Description Homo sapiens hsa-miR-32-3p mature miRNA
Sequence 47 - CAAUUUAGUGUGUGUGAUAUUU - 68
Evidence experimental
cloned [2]
Database links
Predicted targets

References

  1. PubMed ID: 11679670
    Identification of novel genes coding for small expressed RNAs
    "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
    "Science (2001) 294:853-858

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414