miRBase entry: hsa-mir-95

Stem-loop hsa-mir-95


Accession
MI0000097
Symbol
HGNC: MIR95
Description
Homo sapiens hsa-mir-95 precursor miRNA
Gene family
MIPF0000098; mir-95

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR95 is a microRNA that is highly expressed in prostate and lung cancers and has oncogenic function [PMC5302951]. In patients with primary myelofibrosis, there is a decrease in the expression of MIR95 [PMC6183594]. MIR95 has also been found to be expressed more in tolerant recipients compared to non-tolerant recipients, and it is positively correlated with activated Treg markers [PMC7412931]. It has been suggested that a disruption of the binding site of MIR95 may affect its expression and modulatory effect in myogenic cells, indicating its potential role as a disease modifier [PMC6969370]. In pancreatic intraepithelial neoplasms and pancreatic adenocarcinomas, there is an upregulation of MIR95 compared to normal pancreatic tissue [PMC3849454]. Knockdown of MIR95 has been shown to speed up apoptosis induced by irradiation [PMC6525830]. The genomic organization and sequence conservation of MIR95 have been investigated, with experimental validation confirming its relevance as a pool of miRNAs [PMC3874173]. Overall, these findings highlight the importance of MIR95 in various biological processes and disease conditions [PMC5302951, PMC6183594, PMC7412931, PMC6969370, PMC3849454, PMC6525830, PMC3874173]..

Literature search
36 open access papers mention hsa-mir-95
(110 sentences)

Sequence

21118 reads, 406 reads per million, 104 experiments
aacacagugggcacUCAAUAAAUGUCUGUUGAAUUgaaaugcguuacaUUCAACGGGUAUUUAUUGAGCAcccacucugug
.(((.((((((..((((((((((((((((((((((((......))).)))))))))))))))))))))..)))))).))).

Structure
a   c      ca                     -   aa 
 aca aguggg  cUCAAUAAAUGUCUGUUGAAU Uga  u
 ||| ||||||  ||||||||||||||||||||| |||   
 ugu ucaccc  GAGUUAUUUAUGGGCAACUUa auu  g
g   c      AC                     c   gc 


Annotation confidence Not enough data
Do you think this miRNA is real?
Comments
This sequence is localised to chromosome 4 and was named mir-95-4 in reference [1].

Genome context
chr4: 8005301-8005381 [-]

Disease association
hsa-mir-95 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-95-3p

Accession MIMAT0000094
Description Homo sapiens hsa-miR-95-3p mature miRNA
Sequence 49 - UUCAACGGGUAUUUAUUGAGCA - 70
Evidence experimental
cloned [1-2], Illumina [3]
Database links
Predicted targets

Mature hsa-miR-95-5p

Accession MIMAT0026473
Description Homo sapiens hsa-miR-95-5p mature miRNA
Sequence 15 - UCAAUAAAUGUCUGUUGAAUU - 35
Evidence experimental
Illumina [3]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 11914277
    miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
    "Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G"
    "Genes Dev (2002) 16:720-728

  3. PubMed ID: 23034410
    Birth and expression evolution of mammalian microRNA genes
    "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
    "Genome Res (2013) 23:34-45