Stem-loop hsa-mir-105-1

Accession

MI0000111

Symbol

HGNC: MIR105-1

Description

Homo sapiens hsa-mir-105-1 precursor miRNA

Gene family

MIPF0000074; mir-105

Literature search

35 open access papers mention hsa-mir-105-1
(55 sentences)

Sequence

2243 reads, 162 reads per million, 40 experiments

ugugcaucguggUCAAAUGCUCAGACUCCUGUGGUggcugcucaugcaccACGGAUGUUUGAGCAUGUGCUAcggugucua
...(((((((((.((.((((((((((..((((((((..........))))))))..)))))))))).)))))))))))...

Structure

ugu         U  A          UC        gcug 
   gcaucgugg CA AUGCUCAGAC  CUGUGGUg    c
   ||||||||| || ||||||||||  ||||||||     
   uguggcAUC GU UACGAGUUUG  GGCAccac    u
auc         -  G          UA        guac 

Annotation confidence High

Comments

Mourelatos et al. [1] reported two identical predicted stem loop sequences located on chromosome X, which they named mir-105-X.1 and mir-105-X.2. These sequences have been renamed mir-105-1 (MIR:MI0000111) and mir-105-2 (MIR:MI0000112) here. mir-105-2 differs slightly from that published in [1] and deposited in EMBL (EMBL:AF480548). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chrX: 152392219-152392299 [-]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-105-1

Disease association

hsa-mir-105-1 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-105-5p

• Accession: MIMAT0000102
• Description: Homo sapiens hsa-miR-105-5p mature miRNA
• Sequence: 13 - UCAAAUGCUCAGACUCCUGUGGU - 35
• Evidence: experimental ; cloned [1-2]

Mature hsa-miR-105-3p

• Accession: MIMAT0004516
• Description: Homo sapiens hsa-miR-105-3p mature miRNA
• Sequence: 51 - ACGGAUGUUUGAGCAUGUGCUA - 72
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 11914277
   miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
   "Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G"
   "Genes Dev (2002) 16:720-728