Stem-loop mmu-mir-188

Accession

MI0000230

Symbol

MGI: Mir188

Description

Mus musculus mmu-mir-188 precursor miRNA

Gene family

MIPF0000113; mir-188

Literature search

36 open access papers mention mmu-mir-188
(259 sentences)

Sequence

6008 reads, 106 reads per million, 95 experiments

ucucaCAUCCCUUGCAUGGUGGAGGGugagcucucugaaaacccCUCCCACAUGCAGGGUUUGCAgga
(((..((..(((((((((..((((((....(.....).....))))))..)))))))))..))..)))

Structure

   ca  UC         GU      -ugag u 
ucu  CA  CCUUGCAUG  GGAGGG     c c
|||  ||  |||||||||  ||||||     | u
agg  GU  GGGACGUAC  CCUCcc     g c
   AC  UU         AC      caaaa u 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

chrX: 7247989-7248056 [-]

Clustered miRNAs

3 other miRNAs are < 10 kb from mmu-mir-188

Mature mmu-miR-188-5p

• Accession: MIMAT0000217
• Description: Mus musculus mmu-miR-188-5p mature miRNA
• Sequence: 6 - CAUCCCUUGCAUGGUGGAGGG - 26
• Evidence: experimental ; cloned [1-3], Illumina [4-5]

Mature mmu-miR-188-3p

• Accession: MIMAT0004541
• Description: Mus musculus mmu-miR-188-3p mature miRNA
• Sequence: 45 - CUCCCACAUGCAGGGUUUGCA - 65
• Evidence: experimental ; cloned [3], Illumina [4-5]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12554859
   New microRNAs from mouse and human
   "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
   "RNA (2003) 9:175-179


3. PubMed ID: 15538371
   A pancreatic islet-specific microRNA regulates insulin secretion
   "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
   "Nature (2004) 432:226-230


4. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


5. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009