miRBase entry: mmu-mir-206

Stem-loop mmu-mir-206


Accession
MI0000249
Symbol
MGI: Mir206
Description
Mus musculus mmu-mir-206 precursor miRNA
Gene family
MIPF0000038; mir-1

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

Mmu-mir-206 is a microRNA that is found in mice [PMC4383946]. It has the same sequence as hsa-miR-206, which is found in humans [PMC4383946]. Mmu-mir-206 has been shown to be positively regulated by IGF1 treatment in combination with MAPK/ERK-inhibitor treatment, along with other myogenic markers [PMC4325962]. However, the downregulation of mmu-mir-206 by TNF-α was diminished when a MAPK/ERK inhibitor was applied, and myogenic marker expression was unaffected [PMC4325962]. The effect on miRNA processing seems to be miRNA-specific and precursor-specific [PMC4325962]. Mmu-mir-206 has been found to be inhibited by Rb1 treatment, with the most significant inhibitory effect on mmu-miR-134 [PMC9120625]. Mmu-mir-206 has also been associated with other genes and transcription factors after ovariectomy and orchiectomy in mice [PMC7074395]. The expression of mmu-mir-206 increases progressively with time of embryonic development in mice [PMC1635289]. It has also been shown to be involved in muscle cell differentiation and is associated with specific target genes such as Ezh2, Epha2, and Gja1 [PMC3753644]. The expression levels of mmu-mir-206 vary depending on age and muscle type in mice [PMC6250799]. TargetScanFish 6.2, TargetScan 7.2, and TargetScanMouse 7.2 have been used to analyze dre-miR-206-3p, hsa-miR-206, and mmu-mir-206 respectively[ PMC8055004]..
In situ hybridization using a locked nucleic acid (LNA) detection probe has been performed to detect mmu-mir-206 [PMC3422271]. The levels of mmu-mir-206 can be inhibited or overexpressed using specific inhibitors or constructs [PMC3973319]. The numbers of constructs encoding mmu-mir-1-1, mmu-mir-1-2, and mmu-mir-206 in mice are 20, 6, and 6 respectively [PMC2613404].

Literature search
193 open access papers mention mmu-mir-206
(2338 sentences)

Sequence

563617 reads, 3121 reads per million, 83 experiments
ccaggccACAUGCUUCUUUAUAUCCUCAUAgauaucucagcacuaUGGAAUGUAAGGAAGUGUGUGGuuuugg
(((((((((((((((((((((((.(.(((((...........)))))).)))))))))))))))))).)))))

Structure
     -                  C U     auau 
ccagg ccACAUGCUUCUUUAUAU C CAUAg    c
||||| |||||||||||||||||| | |||||    u
gguuu GGUGUGUGAAGGAAUGUA G GUauc    c
     u                  A -     acga 


Annotation confidence Not enough data
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Genome context
chr1: 20679010-20679082 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from mmu-mir-206
Name Accession Chromosome Start End Strand Confidence




Database links

Mature mmu-miR-206-5p

Accession MIMAT0017004
Description Mus musculus mmu-miR-206-5p mature miRNA
Sequence 8 - ACAUGCUUCUUUAUAUCCUCAUA - 30
Evidence experimental
Illumina [4]

Mature mmu-miR-206-3p

Accession MIMAT0000239
Description Mus musculus mmu-miR-206-3p mature miRNA
Sequence 46 - UGGAAUGUAAGGAAGUGUGUGG - 67
Evidence experimental
cloned [1-2], Illumina [3-4]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12554859
    New microRNAs from mouse and human
    "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
    "RNA (2003) 9:175-179

  3. PubMed ID: 20215419
    MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
    "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
    "Mol Hum Reprod (2010) 16:463-471

  4. PubMed ID: 20413612
    Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
    "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
    "Genes Dev (2010) 24:992-1009