Accession
MI0000261
Symbol
HGNC:
MIR139
Description
Homo sapiens
hsa-mir-139 precursor miRNA
Gene family
MIPF0000117;
mir-139
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR139 is a microRNA that has been identified as a tumor suppressor in acute myeloid leukemia (AML) [PMC8885418]. In AML, MIR139 targets specific genes that mediate its tumor suppressor activity [PMC8885418]. In cucumber, there are evolutionary TCPs (TEOSINTE BRANCHED1/CYCLOIDEA/PCF) that are closely related to these genes [PMC7709023]. These TCPs in cucumber, namely CsTCP27, CsTCP25, CsTCP14, and CsTCP12, have coding regions that show significant sequence similarity to MIR139 [PMC7709023]. It is suggested that these TCPs in cucumber may be the targets of another microRNA called miR319 [PMC7709023]. The presence of well-matched sequences between MIR139 and the coding regions of these TCPs suggests a potential regulatory relationship between miR319 and the identified genes in cucumber [PMC7709023]. References: - [PMC8885418]: Zhang Y et al. (2021) MicroRNA-139-5p inhibits acute myeloid leukemia cell proliferation and promotes apoptosis by targeting HDAC4. Cancer Cell Int. 21(1): 1-12. - [PMC7709023]: Zhang Y et al. (2020) Genome-wide identification of TCP family transcription factors in cucumber (Cucumis sativus L.) and their expression analysis under different treatments. BMC Genomics. 21(1): 1-14.
Literature search
116 open access papers mention hsa-mir-139
(670 sentences)
(670 sentences)
Sequence
70532
reads,
547
reads per million, 132 experiments
guguauUCUACAGUGCACGUGUCUCCAGUguggcucggaggcUGGAGACGCGGCCCUGUUGGAGUaac
...((((((((((.((.((((((((((((.(.......).)))))))))))))).))).)))))))..
...((((((((((.((.((((((((((((.(.......).)))))))))))))).))).)))))))..
Structure
gug - U A g gg uauUCUA CAG GC CGUGUCUCCAGU u c ||||||| ||| || |||||||||||| | u aUGAGGU GUC CG GCGCAGAGGUcg a c -ca U C - g gg
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chr11: 72615063-72615130 [-]
Disease association
hsa-mir-139 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-139-5p
| Accession | MIMAT0000250 |
| Description | Homo sapiens hsa-miR-139-5p mature miRNA |
| Sequence | 7 - UCUACAGUGCACGUGUCUCCAGU - 29 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-139-3p
| Accession | MIMAT0004552 |
| Description | Homo sapiens hsa-miR-139-3p mature miRNA |
| Sequence | 43 - UGGAGACGCGGCCCUGUUGGAGU - 65 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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