miRBase entry: hsa-mir-302a

Stem-loop hsa-mir-302a


Accession
MI0000738
Symbol
HGNC: MIR302A
Description
Homo sapiens hsa-mir-302a precursor miRNA
Gene family
MIPF0000071; mir-302

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR302A is a microRNA that is part of the miR-302 family, which includes MIR302B, MIR302C, and MIR302D [PMC5906557]. It is highly expressed in embryonic stem cells but declines rapidly after differentiation [PMC6722449]. MIR302A has been shown to be involved in various biological processes and diseases. For example, it has been found to be associated with the inhibition of EC migration and proliferation in end-stage renal disease [PMC8685359]. In addition, dysregulation of MIR302A has been implicated in hepatocarcinogenesis and contributes to microvesicle-mediated transfer of miRNAs and dysfunction of the NF-κB signaling pathway [PMC4761210]. Furthermore, MIR302A has been shown to regulate the expression of p65 by binding with ZFP91 directly [PMC8365611]. It has also been found to be related to tumor size and metastasis in colorectal cancer patients [PMC7602903]. Moreover, overexpression of miR-302s (including MIR302A) induces apoptosis in cancer cell lines [PMC4400607]. Overall, MIR302A plays a crucial role in various biological processes and diseases through its regulation of gene expression.

Literature search
193 open access papers mention hsa-mir-302a
(1105 sentences)

Sequence

1300 reads, 362 reads per million, 16 experiments
ccaccACUUAAACGUGGAUGUACUUGCUuugaaacuaaagaagUAAGUGCUUCCAUGUUUUGGUGAugg
(((.((((.(((((((((.(((((((((((.........))))))))))).))))))))).)))).)))

Structure
   c    U         U           gaa 
cca cACU AAACGUGGA GUACUUGCUuu   a
||| |||| ||||||||| |||||||||||   c
ggu GUGG UUUGUACCU CGUGAAUgaag   u
   A    U         U           aaa 


Annotation confidence High
Do you think this miRNA is real?

Genome context
chr4: 112648183-112648251 [-]
Clustered miRNAs
4 other miRNAs are < 10 kb from hsa-mir-302a
Name Accession Chromosome Start End Strand Confidence



Biological pathways
hsa-mir-302a is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-302a is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-302a-5p

Accession MIMAT0000683
Description Homo sapiens hsa-miR-302a-5p mature miRNA
Sequence 6 - ACUUAAACGUGGAUGUACUUGCU - 28
Evidence experimental
cloned [2,4], Northern [2]
Database links
Predicted targets

Mature hsa-miR-302a-3p

Accession MIMAT0000684
Description Homo sapiens hsa-miR-302a-3p mature miRNA
Sequence 44 - UAAGUGCUUCCAUGUUUUGGUGA - 66
Evidence experimental
cloned [2,4], Northern [2]
Database links
Predicted targets

References

  1. PubMed ID: 15183728
    Human embryonic stem cells express a unique set of microRNAs
    "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
    "Dev Biol (2004) 270:488-498

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 12919684
    Embryonic stem cell-specific MicroRNAs
    "Houbaviy HB, Murray MF, Sharp PA"
    "Dev Cell (2003) 5:351-358

  4. PubMed ID: 15634332
    New human and mouse microRNA genes found by homology search
    "Weber MJ"
    "FEBS J (2005) 272:59-73