miRBase entry: hsa-mir-362

Stem-loop hsa-mir-362


Accession
MI0000762
Symbol
HGNC: MIR362
Description
Homo sapiens hsa-mir-362 precursor miRNA
Gene family
MIPF0000209; mir-362

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR362 is a miRNA that is part of a cluster of eight miRNAs located in the intron 3 of the CLCN5 gene on the short arm of the X chromosome [PMC8253104]. It is regulated by TERT and is downstream of miR500A [PMC8253104]. MiR500A and all miRNAs downstream of the cluster are known to act as oncomiRs and are associated with various cancer types, including hepatocellular carcinoma, gastric cancer, and breast cancer [PMC8253104]. In gastric cancer tissues, upregulation of MIR362 has been shown to promote cell proliferation and resistance to apoptosis [PMC4241533]. Higher levels of MIR362 expression have been observed in H1299 and 95-D cell lines compared to H460 and A549 cell lines [PMC6093061]. MIR362 has also been identified as a potential regulator of target mRNAs along with miR21, miR34a, and miR203 [PMC9097102]. The expression profile and secretion pattern of MIR362 may play a role in the complex development and endocrine function of adipose tissue [PMC4892883]. The processing and maturation of MIR362 requires the RNA-processing enzyme Dicer, which has been found to decline over time in various organisms including mice with adipose-specific deficiency in Dicer showing effects on white adipose tissue development when challenged by a high-fat diet [PMC9097102] [PMC4892883]

Literature search
41 open access papers mention hsa-mir-362
(140 sentences)

Sequence

19749 reads, 208 reads per million, 124 experiments
cuugAAUCCUUGGAACCUAGGUGUGAGUgcuauuucagugcAACACACCUAUUCAAGGAUUCAaa
.(((((((((((((...((((((((.(((((.....)))))..))))))))))))))))))))).

Structure
c             ACC        -A     a 
 uugAAUCCUUGGA   UAGGUGUG  GUgcu u
 |||||||||||||   ||||||||  ||||| u
 aACUUAGGAACUU   AUCCACAC  cguga u
a             ---        AA     c 


Annotation confidence High
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Genome context
chrX: 50008964-50009028 [+]
Clustered miRNAs
7 other miRNAs are < 10 kb from hsa-mir-362
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-362 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-362-5p

Accession MIMAT0000705
Description Homo sapiens hsa-miR-362-5p mature miRNA
Sequence 5 - AAUCCUUGGAACCUAGGUGUGAGU - 28
Evidence experimental
array-cloned [1], cloned [2-3]
Database links
Predicted targets

Mature hsa-miR-362-3p

Accession MIMAT0004683
Description Homo sapiens hsa-miR-362-3p mature miRNA
Sequence 42 - AACACACCUAUUCAAGGAUUCA - 63
Evidence experimental
cloned [3]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15965474
    Identification of hundreds of conserved and nonconserved human microRNAs
    "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
    "Nat Genet (2005) 37:766-770

  3. PubMed ID: 16274478
    Identification of clustered microRNAs using an ab initio prediction method
    Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
    BMC Bioinformatics (2005) 6:267