Accession
MI0000773
Symbol
HGNC:
MIR302C
Description
Homo sapiens
hsa-mir-302c precursor miRNA
Gene family
MIPF0000071;
mir-302
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR302C is one of the upregulated genes associated with the inhibition of EC migration and proliferation in ESRD-hiPSC-ECs [PMC8685359]. However, MIR302C is not expressed in pulmonary cells [PMC4125569]. The pathway of GSEA enrichment includes MIR302C and is associated with various cancer-related processes [PMC9130929]. MIR302C expression is induced by JMJD2 demethylase binding in its promoter region and reduces H3K9me2 methylation [PMC4501658]. PRP-1, a cytostatic peptide, downregulates MIR302C targets, including stemness markers Nanog and c-Myc [PMC4501658]. Overexpression of miR302s, including MIR302C, induces massive apoptosis in cancer cell lines [PMC4400607]. MIR302C is part of the miR-302 family that plays a key role in pluripotency and cell reprogramming [PMC4433211]. It is also downregulated in pancreatic cancer and associated with age-related decline [PMC6154866][PMC6046043[PMC6046043]. Activation of canonical BMP signaling upregulates miR302b and MIR302C expression [PMC4164941]. The miR-302 cluster includes miR-302b, MIR302C, miR-302a, miR- 02d, and miR367 that are highly expressed in embryonic stem cells but decline after differentiation [PMC6722449][PMC7555329].[PMC7555329].\
Literature search
192 open access papers mention hsa-mir-302c
(955 sentences)
(955 sentences)
Sequence
23
reads,
4
reads per million, 5 experiments
ccuuugcUUUAACAUGGGGGUACCUGCUGugugaaacaaaagUAAGUGCUUCCAUGUUUCAGUGGagg
((((((((..(((((((((((((.((((.(((...)))..)))).)))))))))))))..))))))))
((((((((..(((((((((((((.((((.(((...)))..)))).)))))))))))))..))))))))
Structure
UU C -G g
ccuuugcU AACAUGGGGGUAC UGCU ugu
|||||||| ||||||||||||| |||| ||| a
ggaGGUGA UUGUACCUUCGUG AUga aca
CU A aa a
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr4: 112648363-112648430 [-]
Clustered miRNAs
4 other miRNAs are < 10 kb from hsa-mir-302c
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Database links
Mature hsa-miR-302c-5p
| Accession | MIMAT0000716 |
| Description | Homo sapiens hsa-miR-302c-5p mature miRNA |
| Sequence | 8 - UUUAACAUGGGGGUACCUGCUG - 29 |
| Evidence |
experimental
cloned [1-2], Northern [1] |
Mature hsa-miR-302c-3p
| Accession | MIMAT0000717 |
| Description | Homo sapiens hsa-miR-302c-3p mature miRNA |
| Sequence | 43 - UAAGUGCUUCCAUGUUUCAGUGG - 65 |
| Evidence |
experimental
cloned [1-2], Northern [1] |
| Database links |
|
| Predicted targets |
|
References
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