miRBase entry: hsa-mir-302d

Stem-loop hsa-mir-302d


Accession
MI0000774
Symbol
HGNC: MIR302D
Description
Homo sapiens hsa-mir-302d precursor miRNA
Gene family
MIPF0000071; mir-302

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR302D is a member of the miR-302 family, which includes mature miRNAs encoded by genes MIR302A, MIR302B, MIR302C, and MIR302D [PMC5906557]. In morphine-treated organoids, the levels of miR186, miR181a, and MIR302D were increased [PMC8225561]. Let7c-5p potentially targets IL-6 and TLR4; IL-1α is a predicted target of miR181a and miR410; several microRNAs including MIR302D potentially regulate the expression of IL-25 [PMC8225561]. c-Jun is identified as a potential upstream transcript factor for MIR302D [PMC5906557]. The regulatory role of c-Jun on MIR302D expression is implied in the study [PMC5906557]. MiR-302d-3p is the mature miRNA encoded by the MIR302D gene located on 4q25 [PMC5906557]. The study used SP600125 and anisomycin to suppress or promote the JNK pathway and c-Jun activation to investigate their effect on MIR302D expression [PMC5906557]. MIR302D is highly expressed in both pluripotent stem cells and multipotent progenitor cells [PMC5966391]. MIR302D is one of the upregulated genes associated with the inhibition of endothelial cell migration and proliferation in ESRD-hiPSC-ECs [PMC8685359].

Literature search
182 open access papers mention hsa-mir-302d
(929 sentences)

Sequence

33 reads, 4 reads per million, 9 experiments
ccucuACUUUAACAUGGAGGCACUUGCugugacaugacaaaaaUAAGUGCUUCCAUGUUUGAGUGUgg
((..(((((.((((((((((((((((.(((......)))....)))))))))))))))).))))).))

Structure
  uc     U                ---C   ga 
cc  uACUU AACAUGGAGGCACUUG    ugu  c
||  ||||| ||||||||||||||||    |||   
gg  GUGAG UUGUACCUUCGUGAAU    aca  a
  -U     U                aaaa   gu 


Annotation confidence Not enough data
Do you think this miRNA is real?
Comments
Human miR-302a (MIR:MI0000738), miR-302b (MIR:MI0000772), miR-302c (MIR:MI0000773), miR-302d (MIR:MI0000774) and miR-367 (MIR:MI0000775) are clustered on chromosome 4.

Genome context
chr4: 112648004-112648071 [-]
Clustered miRNAs
4 other miRNAs are < 10 kb from hsa-mir-302d
Name Accession Chromosome Start End Strand Confidence




Database links

Mature hsa-miR-302d-5p

Accession MIMAT0004685
Description Homo sapiens hsa-miR-302d-5p mature miRNA
Sequence 6 - ACUUUAACAUGGAGGCACUUGC - 27
Evidence experimental
cloned [2]

Mature hsa-miR-302d-3p

Accession MIMAT0000718
Description Homo sapiens hsa-miR-302d-3p mature miRNA
Sequence 44 - UAAGUGCUUCCAUGUUUGAGUGU - 66
Evidence experimental
cloned [1-2], Northern [1]
Database links
Predicted targets

References

  1. PubMed ID: 15183728
    Human embryonic stem cells express a unique set of microRNAs
    "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
    "Dev Biol (2004) 270:488-498

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414