Accession
MI0000776
Symbol
HGNC:
MIR376C
Description
Homo sapiens
hsa-mir-376c precursor miRNA
Gene family
MIPF0000091;
mir-368
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR376C is a microRNA that undergoes rapid turnover, and its abundance and function are highly dependent on the continued transcription and processing of pri-MIR376C [PMC7486624]. The expression of MIR376C leads to an increase in the repression of α1 and γ2 translation, resulting in a reduction in the number of functional synapses at dendritic inhibitory synapses [PMC7486624]. This reduction is manifested by a decrease in the total number of functional synapses [PMC7486624]. The findings suggest that MIR376C plays a crucial role in regulating GABAARs at dendritic inhibitory synapses, potentially impacting synaptic transmission and neuronal excitability [PMC7486624]. Further research is needed to fully understand the mechanisms by which MIR376C influences GABAARs and its implications for neuronal function.
Literature search
80 open access papers mention hsa-mir-376c
(327 sentences)
(327 sentences)
Sequence
13204
reads,
330
reads per million, 99 experiments
aaaaGGUGGAUAUUCCUUCUAUGUUuauguuauuuaugguuaAACAUAGAGGAAAUUCCACGUuuu
((((.(((((..(((((.(((((((((.............))))))))))))))..))))).))))
((((.(((((..(((((.(((((((((.............))))))))))))))..))))).))))
Structure
G UA U uguua
aaaa GUGGA UUCCU CUAUGUUua u
|||| ||||| ||||| ||||||||| u
uuuU CACCU AAGGA GAUACAAau u
G UA - uggua
Annotation confidence
High
Do you think this miRNA is real?
Comments
This miRNA has been named both miR-368 and miR376c in the literature, and previously here. The mature miR-376c product has been shown to be modified by A to I edits [3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4]. The 5' end of the miRNA may be offset with respect to previous annotations.
Genome context
chr14: 101039690-101039755 [+]
Clustered miRNAs
16 other miRNAs are < 10 kb from hsa-mir-376c
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-376c is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-376c-3p
| Accession | MIMAT0000720 |
| Description | Homo sapiens hsa-miR-376c-3p mature miRNA |
| Sequence | 43 - AACAUAGAGGAAAUUCCACGU - 63 |
| Evidence |
experimental
cloned [1-2,4], Northern [1], SOLiD [5] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-376c-5p
| Accession | MIMAT0022861 |
| Description | Homo sapiens hsa-miR-376c-5p mature miRNA |
| Sequence | 5 - GGUGGAUAUUCCUUCUAUGUU - 25 |
| Evidence |
experimental
SOLiD [5] |
| Database links |
|
| Predicted targets |
|
References
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