miRBase entry: hsa-mir-380

Stem-loop hsa-mir-380


Accession
MI0000788
Symbol
HGNC: MIR380
Description
Homo sapiens hsa-mir-380 precursor miRNA
Gene family
MIPF0000126; mir-379

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR380 is a microRNA that has been shown to attenuate p53 signaling in neuroblastoma and is transcribed from the maternal chromosome along the Rian extension of the Dlk1-Dio3 imprinted domain [PMC8044846] [PMC3919614]. Inhibitory experiments have demonstrated that HDAC3 plays a regulatory role in mesenchymal stem cells (MSCs) by stimulating the expression of Tumor Susceptibility Gene 101 (TSG101) and increasing the content of MIR380 and miR382 in MSC-derived exosomes [PMC8044846]. miR382 is overexpressed in multiple myeloma (MM) patients and targets tumor suppressor genes involved in tumor proliferation and survival, suggesting a pathogenetic function for this microRNA [PMC8044846] [PMC6883144]. Knockdown of HDAC3 leads to a decrease in exosomal expression of MIR380, miR382, as well as other pro-survival microRNAs such as miR15b, miR9986, and miR5191, resulting in cell growth arrest [PMC8392438] [PMC6883144]. Co-culturing MM cells with HDAC3-expressing cells leads to increased expression of pro-survival microRNAs including MIR380 and miR382 in exosomes derived from MM cells [PMC6883144]. These findings suggest that MIR380 and miR382 may have important roles in regulating cell survival and proliferation, particularly in the context of neuroblastoma and MM.

Literature search
13 open access papers mention hsa-mir-380
(18 sentences)

Sequence

1033 reads, 36 reads per million, 53 experiments
aagaUGGUUGACCAUAGAACAUGCGCuaucucugugucgUAUGUAAUAUGGUCCACAUCUU
((((((...(((((((..(((((((.(((....))).)))))))..)))))))..))))))

Structure
      GUU       GA       C   c 
aagaUG   GACCAUA  ACAUGCG uau u
||||||   |||||||  ||||||| |||  
UUCUAC   CUGGUAU  UGUAUgc gug c
      -AC       AA       u   u 


Annotation confidence High
Do you think this miRNA is real?
Comments
Landgraf et al. confirm that the 3' product is the predominant one [3].

Genome context
chr14: 101025017-101025077 [+]
Clustered miRNAs
12 other miRNAs are < 10 kb from hsa-mir-380
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-380 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-380-5p

Accession MIMAT0000734
Description Homo sapiens hsa-miR-380-5p mature miRNA
Sequence 5 - UGGUUGACCAUAGAACAUGCGC - 26
Evidence not_experimental

Mature hsa-miR-380-3p

Accession MIMAT0000735
Description Homo sapiens hsa-miR-380-3p mature miRNA
Sequence 40 - UAUGUAAUAUGGUCCACAUCUU - 61
Evidence experimental
cloned [3]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15538371
    A pancreatic islet-specific microRNA regulates insulin secretion
    "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
    "Nature (2004) 432:226-230

  3. PubMed ID: 15310658
    A large imprinted microRNA gene cluster at the mouse Dlk1-Gtl2 domain
    "Seitz H, Royo H, Bortolin ML, Lin SP, Ferguson-Smith AC, Cavaille J"
    "Genome Res (2004) 14:1741-1748