miRBase entry: hsa-mir-323a

Stem-loop hsa-mir-323a


Accession
MI0000807
Symbol
HGNC: MIR323A
Description
Homo sapiens hsa-mir-323a precursor miRNA
Gene family
MIPF0000018; mir-154

Literature search
45 open access papers mention hsa-mir-323a
(107 sentences)

Sequence

2423 reads, 46 reads per million, 60 experiments
uugguacuuggagagAGGUGGUCCGUGGCGCGUUCGCuuuauuuauggcgCACAUUACACGGUCGACCUCUuugcaguaucuaauc
..((((((.(.((((((((.(.(((((..(.((.((((........)))).)).)..))))).).)))))))).))))))).....

Structure
---uu      u g        G U     GC C  U    uua 
     gguacu g agagAGGU G CCGUG  G GU CGCu   u
     |||||| | |||||||| | |||||  | || ||||    
     cuauga c uuUCUCCA C GGCAC  U CA gcgg   u
cuaau      - g        G U     AU A  C    uau 


Annotation confidence High
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Comments
This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,2], later verified in human [3].

Genome context
chr14: 101025732-101025817 [+]
Clustered miRNAs
12 other miRNAs are < 10 kb from hsa-mir-323a
Name Accession Chromosome Start End Strand Confidence




Database links

Mature hsa-miR-323a-5p

Accession MIMAT0004696
Description Homo sapiens hsa-miR-323a-5p mature miRNA
Sequence 16 - AGGUGGUCCGUGGCGCGUUCGC - 37
Evidence experimental
cloned [3]

Mature hsa-miR-323a-3p

Accession MIMAT0000755
Description Homo sapiens hsa-miR-323a-3p mature miRNA
Sequence 51 - CACAUUACACGGUCGACCUCU - 71
Evidence experimental
cloned [3]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15634332
    New human and mouse microRNA genes found by homology search
    "Weber MJ"
    "FEBS J (2005) 272:59-73

  3. PubMed ID: 14691248
    Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
    "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
    "Proc Natl Acad Sci U S A (2004) 101:360-365