miRBase entry: hsa-mir-135b

Stem-loop hsa-mir-135b


Accession
MI0000810
Symbol
HGNC: MIR135B
Description
Homo sapiens hsa-mir-135b precursor miRNA
Gene family
MIPF0000028; mir-135

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR135B is a downregulated miRNA in PWS INS-1 lines, along with Mir3065 and Mir212, although their predicted targets were not differentially expressed genes (DEGs) by RNA-seq [PMC10138222]. Experimental evidence has shown that in an in vitro miRNA system, both miR135a and MIR135B interact with the 3’UTR transcript of the APC gene, affecting mRNA levels and regulating APC expression [PMC3843547]. This regulation of APC expression by MIR135B and miR135a has implications for the Wnt proliferation control pathway [PMC3843547].

Literature search
190 open access papers mention hsa-mir-135b
(898 sentences)

Sequence

4823 reads, 126 reads per million, 76 experiments
cacucugcuguggccUAUGGCUUUUCAUUCCUAUGUGAuugcugucccaaacucAUGUAGGGCUAAAAGCCAUGGGcuacagugaggggcgagcucc
..(((((((((((((((((((((((...(((((((((((((......)))..))))))))))..))))))))))))))))))).)))).........

Structure
-------ca    -                   CAU          --   cu 
         cucu gcuguggccUAUGGCUUUU   UCCUAUGUGA  uug  g
         |||| |||||||||||||||||||   ||||||||||  |||   
         ggga ugacaucGGGUACCGAAAA   GGGAUGUAcu  aac  u
ccucgagcg    g                   -UC          ca   cc 


Annotation confidence High
Do you think this miRNA is real?
Comments
This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,2], later verified in human [3].

Genome context
chr1: 205448302-205448398 [-]

Disease association
hsa-mir-135b is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-135b-5p

Accession MIMAT0000758
Description Homo sapiens hsa-miR-135b-5p mature miRNA
Sequence 16 - UAUGGCUUUUCAUUCCUAUGUGA - 38
Evidence experimental
cloned [3-4]
Database links
Predicted targets

Mature hsa-miR-135b-3p

Accession MIMAT0004698
Description Homo sapiens hsa-miR-135b-3p mature miRNA
Sequence 55 - AUGUAGGGCUAAAAGCCAUGGG - 76
Evidence experimental
cloned [3]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 15634332
    New human and mouse microRNA genes found by homology search
    "Weber MJ"
    "FEBS J (2005) 272:59-73

  4. PubMed ID: 14691248
    Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
    "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
    "Proc Natl Acad Sci U S A (2004) 101:360-365