Accession
MI0000815
Symbol
HGNC:
MIR339
Description
Homo sapiens
hsa-mir-339 precursor miRNA
Gene family
MIPF0000193;
mir-339
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR339 is a microRNA that has been studied in various contexts. It has been found that ZMYND8-binding peaks at enhancer regions related to MIR339, Lrrc28, and Lipa were diminished [PMC8586003]. MIR339 is one of the differentially expressed pri-miRNAs in HUVECs and HAECs [PMC8216629]. It has also been identified as a graft-transmissible miRNA in potatoes [PMC10067726]. In the context of ovarian tumors, an increase in the methylation level of MIR339 was associated with metastatic primary ovarian tumors and the onset of OvCa pathogenesis [PMC8835734]. In another study, MIR339 was found to be upregulated after IFN-γ stimulation [PMC8010072]. Additionally, MIR339 was validated as a miRNA in different contexts such as multiple sclerosis and pancreatic ductal adenocarcinoma (PDAC) [PMC6006352] [PMC9599289]. It has also been reported that MIR339 is involved in regulating sucrose degradation and sucrose synthase production at a transcription level [PMC3997385]. Overall, these studies highlight the diverse roles of MIR339 in various biological processes.
Literature search
58 open access papers mention hsa-mir-339
(200 sentences)
(200 sentences)
Sequence
53279
reads,
572
reads per million, 132 experiments
cggggcggccgcucUCCCUGUCCUCCAGGAGCUCACGugugccugccugUGAGCGCCUCGACGACAGAGCCGgcgccugccccagugucugcgc
.(((((((.((((..(.(((((.((.(((.(((((((.((....)).))))))).))).)).))))).)..)))).)))))))...........
.(((((((.((((..(.(((((.((.(((.(((((((.((....)).))))))).))).)).))))).)..)))).)))))))...........
Structure
----------c c cU C C C A u g
ggggcgg cgcu C CUGUC UC AGG GCUCACG gu c
||||||| |||| | ||||| || ||| ||||||| ||
ccccguc gcgG G GACAG AG UCC CGAGUgu cg c
cgcgucuguga c CC A C C G c u
Annotation confidence
High
Do you think this miRNA is real?
Comments
This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,3]. Expression of mature miRNA was later verified in human [2,4]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].
Genome context
chr7: 1022933-1023026 [-]
Disease association
hsa-mir-339 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-339-5p
| Accession | MIMAT0000764 |
| Description | Homo sapiens hsa-miR-339-5p mature miRNA |
| Sequence | 15 - UCCCUGUCCUCCAGGAGCUCACG - 37 |
| Evidence |
experimental
cloned [2,4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-339-3p
| Accession | MIMAT0004702 |
| Description | Homo sapiens hsa-miR-339-3p mature miRNA |
| Sequence | 50 - UGAGCGCCUCGACGACAGAGCCG - 72 |
| Evidence |
experimental
cloned [4] |
| Database links |
|
| Predicted targets |
|
References
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