Accession
MI0000826
Symbol
HGNC:
MIR346
Description
Homo sapiens
hsa-mir-346 precursor miRNA
Gene family
MIPF0000188;
mir-346
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR346 is a microRNA that has been found to play a role in glioma cells. It has been shown that MIR17HG acts as a competing endogenous RNA (ceRNA) by binding to MIR346 and miR-425-5p, which helps to counteract the negative regulatory effect of these microRNAs on the TAL1 gene, thereby influencing the malignant behavior of glioma cells [PMC6348679]. In addition to MIR346, three other genes (C10Orf57, RGR, and SFTPD) were identified in the E-MTAB-1781 dataset, while 34 other genes were found in the SEQC-498 database [PMC10093755]. Furthermore, in a study involving 48 metastatic castration-resistant prostate cancers (mCRPCs), it was observed that 4% of cases had a deep deletion involving both MIR346 and PTEN genes, compared to 22% of cases with deep deletion of PTEN alone [PMC8939142]. These findings highlight the importance of MIR346 in various biological processes and its potential role as a biomarker or therapeutic target.
Literature search
38 open access papers mention hsa-mir-346
(440 sentences)
(440 sentences)
Sequence
536
reads,
40
reads per million, 60 experiments
ggucucuguguugggcgucUGUCUGCCCGCAUGCCUGCCUCUcuguugcucugaaggaggcaggggcugggccugcagcugccugggcagagcgg
.(.((((((..((((((.((((..((((((...((((((((.((..........)))))))))).)).))))..)))).)))))).)))))))..
.(.((((((..((((((.((((..((((((...((((((((.((..........)))))))))).)).))))..)))).)))))).)))))))..
Structure
-g u gu u CU - AUG U guug g cucugu ugggcg cUGU GCCC GC CCUGCCUC cu c | |||||| |||||| |||| |||| || |||||||| || c gagacg guccgu gacg cggg cg ggacggag ga u gg - -g c uc u --g - aguc
Annotation confidence
Not enough data
Do you think this miRNA is real?
Comments
This sequence is the predicted human homologue [2] of a sequence cloned from rat neuronal tissue [1]. The mature miRNA differs from the rat sequence at two positions, and its expression has not been verified in human.
Genome context
chr10: 86264694-86264788 [-]
Disease association
hsa-mir-346 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-346
| Accession | MIMAT0000773 |
| Description | Homo sapiens hsa-miR-346 mature miRNA |
| Sequence | 20 - UGUCUGCCCGCAUGCCUGCCUCU - 42 |
| Evidence | not_experimental |
| Database links |
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| Predicted targets |
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References
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