miRBase entry: rno-mir-17-1

Stem-loop rno-mir-17-1


Accession
MI0000845
Description
Rattus norvegicus rno-mir-17-1 precursor miRNA
Gene family
MIPF0000001; mir-17

Literature search
72 open access papers mention rno-mir-17-1
(577 sentences)

Sequence

84499 reads, 120 reads per million, 495 experiments
gucaggauaauguCAAAGUGCUUACAGUGCAGGUAGuggugugugcaucuACUGCAGUGAAGGCACUUGUGGcauugugcugac
(((((.(((((((((((((((((.((.(((((.(((((.......)).)))))))).)).)))))))).))))))))).)))))

Structure
     g         -        A  G     G   -  gu 
gucag auaauguCA AAGUGCUU CA UGCAG UAG ug  g
||||| ||||||||| |||||||| || ||||| ||| ||  u
caguc uguuacGGU UUCACGGA GU ACGUC Auc ac  g
     g         G        A  G     -   u  gu 


Annotation confidence High
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Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The ends of the miRNA may be offset with respect to previous annotations.

Genome context
chr15: 100179879-100179962 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from rno-mir-17-1
Name Accession Chromosome Start End Strand Confidence




Database links

Mature rno-miR-17-5p

Accession MIMAT0000786
Description Rattus norvegicus rno-miR-17-5p mature miRNA
Sequence 14 - CAAAGUGCUUACAGUGCAGGUAG - 36
Evidence experimental
cloned [1-2], SOLiD [3]

Mature rno-miR-17-1-3p

Accession MIMAT0004710
Description Rattus norvegicus rno-miR-17-1-3p mature miRNA
Sequence 51 - ACUGCAGUGAAGGCACUUGUGG - 72
Evidence experimental
cloned [2], SOLiD [3]

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 20403161
    Small RNA expression and strain specificity in the rat
    Linsen SE, de Wit E, de Bruijn E, Cuppen E
    BMC Genomics (2010) 11:249

  3. PubMed ID: 15345052
    Microarray analysis of microRNA expression in the developing mammalian brain
    Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR
    Genome Biol (2004) 5:R68