miRBase entry: rno-mir-128-1

Stem-loop rno-mir-128-1


Accession
MI0000900
Description
Rattus norvegicus rno-mir-128-1 precursor miRNA
Gene family
MIPF0000048; mir-128

Literature search
17 open access papers mention rno-mir-128-1
(63 sentences)

Sequence

3608357 reads, 2708 reads per million, 494 experiments
ugagcuguuggauuCGGGGCCGUAGCACUGUCUGAgagguuuacauuucUCACAGUGAACCGGUCUCUUUuucagcugcuuc
.((((.((((((...(((((((...((((((..(((((((....)))))))))))))...)))))))...)))))).)))).

Structure
u    u      uuC       UAG      CU       u 
 gagc guugga   GGGGCCG   CACUGU  GAgaggu u
 |||| ||||||   |||||||   ||||||  |||||||  
 uucg cgacuu   CUCUGGC   GUGACA  CUcuuua a
c    u      UUU       CAA      --       c 


Annotation confidence High
Do you think this miRNA is real?
Comments
The most commonly cloned mature sequences derived from the previously annotated mir-128a and mir-128b were shown by Landgraf et al to be identical [3]. The sequences are therefore renamed mir-128-1 and mir-128-2.

Genome context
chr13: 44916534-44916615 [+]

Database links

Mature rno-miR-128-1-5p

Accession MIMAT0017118
Description Rattus norvegicus rno-miR-128-1-5p mature miRNA
Sequence 15 - CGGGGCCGUAGCACUGUCUGA - 35
Evidence experimental
SOLiD [3]

Mature rno-miR-128-3p

Accession MIMAT0000834
Description Rattus norvegicus rno-miR-128-3p mature miRNA
Sequence 50 - UCACAGUGAACCGGUCUCUUU - 70
Evidence experimental
cloned [1-4], Northern [1], SOLiD [5]

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 20403161
    Small RNA expression and strain specificity in the rat
    Linsen SE, de Wit E, de Bruijn E, Cuppen E
    BMC Genomics (2010) 11:249

  3. PubMed ID: 15345052
    Microarray analysis of microRNA expression in the developing mammalian brain
    Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR
    Genome Biol (2004) 5:R68