Stem-loop rno-mir-128-2

Accession

MI0000901

Description

Rattus norvegicus rno-mir-128-2 precursor miRNA

Gene family

MIPF0000048; mir-128

Literature search

17 open access papers mention rno-mir-128-2
(64 sentences)

Sequence

2998559 reads, 2284 reads per million, 494 experiments

ugugcagugggaagGGGGGCCGAUGCACUGUAAGAgagugaguagcaggucUCACAGUGAACCGGUCUCUUUcccuacuguguc
...((((((((.((((((((((...((((((..((((.(........).))))))))))...)))))))))).))))))))...

Structure

ugu        a          AUG      AA    g gag 
   gcaguggg agGGGGGCCG   CACUGU  GAga u   u
   |||||||| ||||||||||   ||||||  |||| |    
   ugucaucc UUUCUCUGGC   GUGACA  CUcu g   a
cug        c          CAA      --    g acg 

Annotation confidence High

Comments

The most commonly cloned mature sequences derived from the previously annotated mir-128a and mir-128b were shown by Landgraf et al to be identical [3]. The sequences are therefore renamed mir-128-1 and mir-128-2.

Genome context

chr8: 120378945-120379028 [-]

Mature rno-miR-128-3p

• Accession: MIMAT0000834
• Description: Rattus norvegicus rno-miR-128-3p mature miRNA
• Sequence: 52 - UCACAGUGAACCGGUCUCUUU - 72
• Evidence: experimental ; cloned [1-4], Northern [1], SOLiD [5]

Mature rno-miR-128-2-5p

• Accession: MIMAT0017119
• Description: Rattus norvegicus rno-miR-128-2-5p mature miRNA
• Sequence: 15 - GGGGGCCGAUGCACUGUAAGA - 35
• Evidence: experimental ; SOLiD [5]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 14691248
   Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
   "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
   "Proc Natl Acad Sci U S A (2004) 101:360-365


3. PubMed ID: 20403161
   Small RNA expression and strain specificity in the rat
   Linsen SE, de Wit E, de Bruijn E, Cuppen E
   BMC Genomics (2010) 11:249


4. PubMed ID: 15345052
   Microarray analysis of microRNA expression in the developing mammalian brain
   Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR
   Genome Biol (2004) 5:R68


5. PubMed ID: 17805466
   Cloning and identification of novel microRNAs from rat hippocampus
   "He X, Zhang Q, Liu Y, Pan X"
   "Acta Biochim Biophys Sin (Shanghai) (2007) 39:708-714