miRBase entry: ebv-mir-BHRF1-2

Stem-loop ebv-mir-BHRF1-2


Accession
MI0001065
Description
Epstein Barr virus ebv-mir-BHRF1-2 precursor miRNA
Gene family
MIPF0000332; mir-BHRF1-2


Sequence

cuuuuAAAUUCUGUUGCAGCAGAUAGCugauacccaauguUAUCUUUUGCGGCAGAAAUUGAaag
(((((((.(((((((((((.(((((((...........))))))).))))))))))).)))))))

Structure
       A           C       ugau 
cuuuuAA UUCUGUUGCAG AGAUAGC    a
||||||| ||||||||||| |||||||    c
gaaAGUU AAGACGGCGUU UCUAUug    c
       A           U       uaac 


Annotation confidence Not enough data
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Comments
Pfeffer et al. cloned 5 miRNAs from a Burkitt's lymphoma cell line (BL41) infected with the B95-8 strain of Epstein-Barr virus [1]. They were all confirmed by Northern blot. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The ends of the miRNA may be offset with respect to previous annotations.

Genome context
HHV507799: 42848-42912 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from ebv-mir-BHRF1-2
Name Accession Chromosome Start End Strand Confidence




Disease association
ebv-mir-BHRF1-2 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature ebv-miR-BHRF1-2-5p

Accession MIMAT0000996
Description Epstein Barr virus ebv-miR-BHRF1-2-5p mature miRNA
Sequence 6 - AAAUUCUGUUGCAGCAGAUAGC - 27
Evidence experimental
cloned [1-2], Northern [1]

Mature ebv-miR-BHRF1-2-3p

Accession MIMAT0000997
Description Epstein Barr virus ebv-miR-BHRF1-2-3p mature miRNA
Sequence 41 - UAUCUUUUGCGGCAGAAAUUGA - 62
Evidence experimental
cloned [1-2], Northern [1]

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15118162
    Identification of virus-encoded microRNAs
    "Pfeffer S, Zavolan M, Grasser FA, Chien M, Russo JJ, Ju J, John B, Enright AJ, Marks D, Sander C, Tuschl T"
    "Science (2004) 304:734-736